Pulmonary Cell News Volume 11.03 | Jan 27 2022

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    2022-01-27 | PULCN 11.03


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.03 – 27 January, 2022
    TOP STORY

    Targeting S100A9-ALDH1A1-Retinoic Acid Signaling to Suppress Brain Relapse in EGFR-Mutant Lung Cancer

    Using metastatic models of epidermal growth factor receptor (EGFR)-mutant lung cancer, the authors showed that cancer cells expressing high intracellular S100A9 escaped osimertinib and initiated brain relapses.
    [Cancer Discovery]

    AbstractFull Article

    On-demand Webinar on Studying Cystic Fibrosis using Primary Human Nasal Epithelial Cells - Watch Now
    PUBLICATIONSRanked by the impact factor of the journal

    Characterization of the COPD Alveolar Niche Using Single-Cell RNA Sequencing

    Scientists analyzed single-cell RNA sequencing profiles of explanted lung tissue from subjects with advanced COPD or control lungs and identified a subpopulation of alveolar epithelial type II cells with transcriptional evidence for aberrant cellular metabolism and reduced cellular stress tolerance in COPD.
    [Nature Communications]

    Full Article

    Metabolomic Profiling of Human Pluripotent Stem Cell Differentiation into Lung Progenitors

    Researchers found that the metabolites most enriched during the differentiation from pluripotent stem cell to lung progenitor cell, regardless of cell line, were sphingomyelins and phosphatidylcholines, two important lipid classes in lung development.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    A Medium Composition Containing Normal Resting Glucose That Supports Differentiation of Primary Human Airway Cells

    Investigators expanded and differentiated human basal cells isolated from the nasal and conducting airway to a mature mucociliary epithelial cell layer at air–liquid interface using a medium formulation containing normal resting glucose levels.
    [Scientific Reports]

    Full Article

    SARS-CoV-2 Infection Triggers Paracrine Senescence and Leads to a Sustained Senescence-Associated Inflammatory Response

    In cultured human cells or bronchial organoids, SASR-CoV-2 infection-induced senescent cells expressed high levels of a series of inflammatory factors known as senescence-associated secretory phenotypes 4 in a sustained manner, even after SARS-CoV-2 was no longer detectable.
    [Nature Aging]

    Full Article

    Human Embryonic Mesenchymal Lung-Conditioned Medium Promotes Differentiation to Myofibroblast and Loss of Stemness Phenotype in Lung Adenocarcinoma Cell Lines

    The authors reported that stimuli from the embryonic lung could modulate the malignant phenotype of lung cancer cells, control their growth capacity and activate their differentiation into myofibroblasts.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Estrogen Receptor Beta Promotes Lung Cancer Invasion via Increasing CXCR4 Expression

    Scientists found that estrogen receptor β could promote NSCLC cell invasion via increasing the circular RNA (circRNA), circ-TMX4, expression via directly binding to the 5′ promoter region of its host gene TMX4.
    [Cell Death & Disease]

    Full Article

    Nogo-B Promotes Invasion and Metastasis of Nasopharyngeal Carcinoma via RhoA-SRF-MRTFA Pathway

    Researchers found that higher expression of neurite outgrowth inhibitor B (Nogo-B) was detected in nasopharyngeal carcinoma (NPC) cells and tissues. Higher expression of Nogo-B was statistically relevant to N stage, M stage, and poor prognosis in NPC patients.
    [Cell Death & Disease]

    Full Article

    Treatment of Kidney Clear Cell Carcinoma, Lung Adenocarcinoma and Glioblastoma Cell Lines with Hydrogels Made of DNA Nanostars

    Investigators studied the biological response of three different cell lines to the treatment with DNA-GEL – a DNA-based hydrogel composed of interacting DNA nanostars.
    [Biomaterials Science]

    AbstractGraphical Abstract

    Comparative Study on the Efficacy and Exposure of Molecular Target Agents in Non–Small Cell Lung Cancer PDX Models with Driver Genetic Alterations

    Scientists selected five NSCLC patient-derived xenografts (PDXs) with genetic alterations from established PDXs and the corresponding molecular targeted therapy was administered orally for 21 consecutive days.
    [Molecular Cancer therapeutics]

    Abstract

    CDK4/6-USP51 Axis Regulates Lung Adenocarcinoma Metastasis through ZEB1

    The authors demonstrated that USP51 was overexpressed in metastatic human lung adenocarcinoma and patients with high USP51 expression in their tumors had shorter overall survival than those with low expression of USP51.
    [Cancer Gene Therapy]

    Abstract

    Targeting ADRB2 Enhances Sensitivity of Non-Small Cell Lung Cancer to VEGFR2 Tyrosine Kinase Inhibitors

    Investigators suggested that treatment with vascular endothelial growth factor receptor 2 (VEGFR2)-tyrosine kinase inhibitors upregulated ADRB2 expression in NSCLC cells.
    [Cell Death Discovery]

    Full Article

    RBL2/DREAM-Mediated Repression of the Aurora Kinase A/B Pathway Determines Therapy Responsiveness and Outcome in p53 WT NSCLC

    Researchers found heightened expression of RB-family (RBL) 2 and reduced expression of AURKA/B pathway genes was associated with improved outcomes in p53 wild-type but not p53 mutant NSCLC patients.
    [Scientific Reports]

    Full Article

    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Extracellular Vesicle-Mediated Cellular Crosstalk in Lung Repair, Remodeling and Regeneration

    The authors highlight the extracellular vesicle (EV)-mediated cellular crosstalk that regulates lung homeostasis and discuss the potential of EV therapeutics for lung regenerative medicine.
    [European Respiratory Review]

    Abstract

    The Onset, Development and Pathogenesis of Severe Neutrophilic Asthma

    Scientists discuss the advances made in asthma research, the pathogenesis of neutrophilic asthma, the mechanisms of progression to severe asthma, risk factors for asthma exacerbations, and biomarkers and treatment of neutrophilic asthma.
    [Immunology and Cell Biology]

    AbstractFull Article

    INDUSTRY AND POLICY NEWS

    ArkBio Announces Completion of Patient Enrollment and Dosing in AIRFLO, a Phase III Registration Trial of Ziresovir for Treatment of Respiratory Syncytial Virus Infection

    Ark Biopharmaceutical Co., Ltd. announced the completion of patient enrollment and dosing of ziresovir for the treatment of respiratory syncytial virus infection in a Phase III registration clinical trial.
    [Ark Biopharmaceutical Co., Ltd.]

    Press Release

    FEATURED EVENT

    Cell Therapy Analytics Symposium

    2 March, 2022
    Online

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Lung Carcinogenesis

    Albert Einstein College of Medicine – Bronx, New York, United States

    Professorship – Acute Lung Injury

    German Center for Lung Research – Giessen, Germany

    Clinical Research Scientist – Tissue Injury

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Faculty Position – Pulmonary Medicine

    Albert Einstein College of Medicine – Bronx, New York, United States

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    > See All Jobs

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