 | | Vol. 11.04 – 3 February, 2022 |
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| Scientists identified two 4q12 long noncoding RNAs, LCETRL3 and LCETRL4, which could significantly dimmish epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) efficiency.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Individual cystic fibrosis transmembrane conductance regulator gene function was defined by forskolin-induced swelling, measured as the relative size increase of intestinal organoids after stimulation with 0.8 µM forskolin, quantified as area under the curve.
[European Respiratory Journal] |
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| The authors found a highly significant correlation between pregnancy-associated plasma protein (PAPP)-A expression in idiopathic pulmonary fibrosis lung tissue and disease severity as measured by various pulmonary and physical function tests.
[Journal of Cellular Physiology] |
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| Researchers examined the effects of in vitro treatment of A549 human lung epithelial cells with 17-β-estradiol on mRNA expression of genes coding for these proteins.
[Drug Development Research] |
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| Utilizing an integrated strategy based on scRNA-seq, scTCR-seq, and bulk RNA-seq analysis of fibrotic hypersensitivity pneumonitis profiles, investigators identified ten major cell types and 19 unique subtypes.
[Cell Death Discovery] |
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| The authors examined the viability of BEAS-2B and mRNA/protein expression profile of oxidative stress and inflammatory response-related transcription factors and according inflammatory indicators with a view to evaluate the effects of different interaction models of PM2.5 on epithelial cell damage in vitro.
[Environmental Science and Pollution Research] |
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| By utilizing a ΔNp63-specific conditional knockout mouse model and xenograft models of lung adenocarcinoma and squamous cell carcinoma, scientists found that ∆Np63 promoted NSCLC by maintaining the lung stem cells necessary for lung cancer cell initiation and progression in quiescence.
[Nature Communications] |
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| Researchers explored the biological function of circSHKBP1 in NSCLC. CircSHKBP1 was found to be upregulated in NSCLC tissues and cell lines and was enriched in exosomes derived from NSCLC cells.
[Molecular Therapy Oncolytics] |
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| The authors found that the expression of REV1 was significantly upregulated in lung cancer tissues compared with matched adjacent tissues and was associated with poor prognosis.
[Cell Death & Disease] |
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| The biological role of copine 1 (CPNE1) and receptor for activated C kinase 1 (RACK1) in NSCLC was investigated using gene expression knockdown and overexpression, cell proliferation assays, clonogenic assays, and Transwell assays.
[Cell Communication and Signaling] |
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| Investigators developed a lung adenocarcinoma (LUAD) hypoxia-related gene expression signature. RNAseq was used to identify genes significantly differentially expressed under hypoxia in four LUAD cell lines.
[Scientific Reports] |
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| The high expression of NEK2/3mRNA was significantly associated with poor prognosis in patients with NSCLC, while high expression of NEK1/4/6/7/8/9/10/11mRNA was associated with good prognosis.
[Scientific Reports] |
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| GEPIA database was employed to reveal the expression level of Ovarian tumor protease domain-containing protein 1 (OTUD1) in addition to Krüppel- like factor 4 (KLF4) in NSCLC tissue samples and prove the correlation between OTUD1 and KLF4.
[Thoracic Cancer] |
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| The authors discuss the underlying pathogenesis of irreversible pulmonary fibrosis as well as preclinical disease models, and also suggest directions for future studies.
[Aging and Disease] |
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| Scientists discuss the medical value of nutraceuticals briefly and their ability to mitigate various inflammatory lung diseases through targeting inhibition of NF-κB.
[Chemico-Biological interactions] |
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| A group of international respiratory societies has banned researchers associated with tobacco companies from publishing papers in their journals after the controversial acquisition of a health-care firm that makes inhalers by a tobacco giant.
[Nature] |
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| The Lung Cancer Research Foundation (LCRF) and KRAS Kickers announced a partnership aimed at raising much needed funds for research. Together they to pledged to fund at least one two-year grant in 2022 with the goal of improving outcomes for people with KRAS-mutant lung cancer.
[Lung Cancer Research Foundation] |
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| March 9 – 11, 2022
Melbourne, Victoria, Australia |
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| | King’s College London- London, England, United Kingdom |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | University of Nottingham – Nottingham, England, United Kingdom |
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| | German Center for Lung Research – Giessen, Germany |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
