 | | Vol. 11.05 – 10 February, 2022 |
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| Researchers found that tuberous sclerosis complex subunit 1 (TSC1)/TSC2 loss defined a distinct subtype of NSCLC characterized as inflamed tumor microenvironment and superior sensitivity to immune checkpoint blockade.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Both cigarette smoke-exposed and COPD-patient derived epithelia displayed quantitative evidence of cellular plasticity, with loss of specialized apical features and a transcriptional profile suggestive of partial epithelial to mesenchymal transition, albeit with distinct cell motion indicative of cellular unjamming.
[Journal of Cell Science] |
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| Investigators isolated primary alveolar type-2 cells (AEC2) from patient-derived lung tissues including those from patients with severe emphysema, using magnetic bead-based selection of cells expressing the AEC2 marker HTII-280.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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| The authors demonstrated that antibody-induced leukemia inhibitory factor (LIF) blockade remodeled the lung epithelial transcriptome in association with increased apoptosis.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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| Researchers used a library containing approved drugs to screen for drugs that preferentially reduce cell viability in lung fibroblasts from an idiopathic pulmonary fibrosis patient compared with a human alveolar epithelial cell line.
[Cell Death Discovery] |
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| Scientists investigated the underlying mechanism and pharmacological effect of rhamnazin against pulmonary disorders.
[Phytotherapy Research] |
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| Investigators studied the function of Brahma-related gene-1 (Brg1) in an ovalbumin-induced asthma model and human bronchial epithelial 16HBE cells stably expressing Brg1 shRNA.
[Experimental Physiology] |
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| Researchers showed that a compound termed LCS3, which selectively impaired the growth of human lung adenocarcinoma cells, induced oxidative stress.
[Cell Reports] |
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| Comparison of the 5mC and 5hmC sites revealed that the CD147 gene underwent active demethylation in NSCLC tissues compared with normal tissues, and this demethylation upregulated CD147 expression.
[Oncogene] |
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| Investigators demonstrated the role of oncogenic Ras/syntenin-1 axis in the release of small extracellular vesicles (sEVs) and elucidated the function of syntenin-1-mediated miRNAs in sEVs in lung cancer progression.
[Cell Death & Disease] |
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| The authors investigated the biological functions and potential molecular mechanisms of miR-7-5p in NSCLC undergoing treatment with Everolimus.
[Cell Death & Disease] |
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| Scientists explored clinical factors in 332 advanced NSCLC who received EGFR TKI and molecular characteristics through 65 whole exome sequencing of various EGFR TKI responses including; de novo, intermediate response and long-term response.
[Scientific Reports] |
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| The researchers’ analysis of The Cancer Genome Atlas expression data revealed that p50-associated COX-2 extragenic RNA (PACER) expression was significantly higher in lung adenocarcinomas than normal lung tissues.
[Oncotarget] |
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| As methods to culture lung cancer organoids increase in sophistication, this model will undoubtedly stand its ground in the coming years in every aspect of cancer research, especially with major advantages in the field of personalized medicine and tumor microenvironment research.
[Critical Reviews in Oncology/Hematology] |
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| The authors highlight exosomal micro- and long noncoding RNAs involved in lung cancer chemoresistance and address major molecular mechanisms, which connect corresponding RNA molecules to drug resistance.
[Journal of Cellular Physiology] |
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| The Paul G. Allen Frontiers Group, a division of the Allen Institute, announced 11 awards of $1.3-1.5 million each to fund research projects led by 23 new Allen Distinguished Investigators. Their work spans many parts of the human body, including the liver, lungs, brain, and connective tissues.
[Allen Institute] |
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| April 6 – 9, 2022
Virtual |
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| | Babraham Institute – Babraham, Cambridgeshire, United Kingdom |
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| | University of Washington – Seattle, Washington, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | Wayne State University School of Medicine – Detroit, Michigan, United States |
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| Albert Einstein College of Medicine – Bronx, New York, United States |
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