 | | Vol. 11.06 – 17 February, 2022 |
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| Scientists demonstrated that EP300 mutants lacking acetyltransferase domain accelerated tumor development in mouse models of SCLC.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported that inhalation of the TLR4 ligand LPS upregulated cell surface MHC class I by ∼25-fold on the three subtypes of mouse lung epithelial cells.
[Journal of Immunology] |
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| Kinase inhibitor of IRE1α treatment increased the differentiation of Krt19CreERT2-lineage-traced damage-associated transient progenitors (DATPs) into type 1 alveolar epithelial cells after bleomycin injury, indicating that relief from IRE1α signaling enabled DATPs to exit the transitional state.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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| Researchers found that miR-520a-5p bound the Frizzled 9 (FZD9) 3’UTR in lung cell lines and altered activity and expression of FZD9 downstream targets.
[Scientific Reports] |
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| In vivo, intraperitoneal injection of nifuroxazide relieved and reversed pulmonary fibrosis caused by bleomycin bronchial instillation.
[Respiratory Research] |
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| Investigators quantitatively measured the methylation content of Alu and LINE1 in particulate matter-treated normal human bronchial epithelial cells and normal human epidermal keratinocytes by using whole-genome bisulfite sequencing and pyrosequencing.
[Genes and Environment] |
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| CircRNA paralemmin 2 modulated lipopolysaccharide-caused murine lung epithelial cell injury by the microRNA-330-5p (miR-330-5p)/rho-associated coiled-coil containing protein kinase 2 (ROCK2) pathway, providing a therapeutic target for acute lung injury.
[Immunological investigations] |
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| The authors carried out genome-wide transcriptome analysis and discovered an lncRNA, EMSLR, which was induced both in lung adenocarcinoma and lung squamous cell carcinoma.
[Scientific Reports] |
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| Investigators formulated berberine-loaded liquid crystalline nanoparticles and investigated their in vitro antiproliferative and antimigratory activity in a human lung epithelial cancer cell line.
[Environmental Science and Pollution Research] |
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| Scientists revealed that high serum IL-35 expression was associated with NSCLC cachexia and skeletal muscle atrophy.
[Thoracic Cancer] |
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| The authors summarize the original data obtained from international research laboratories on the oncogenic alterations in each component of the PI3K/Akt/mTOR pathway in lung cancer.
[Translational Oncology] |
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| The efficacy of selumetinib in various solid tumors such as colorectal cancer, lung cancer, neurofibroma, and melanoma is investigated.
[Clinical and Experimental Medicine] |
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| Genetron Holdings Limited announced that it has signed a collaboration agreement with HUTCHMED Limited for the joint development of a companion diagnostic test for ORPATHYS® in China.
[Genetron Holdings Limited] |
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| Zai Lab Limited announced that the Center for Drug Evaluation of the National Medical Products Administration granted Breakthrough Therapy Designation for investigational repotrectinib for the treatment of patients with ROS1-positive metastatic NSCLC who have not been treated with a ROS1 tyrosine kinase inhibitor.
[Zai Lab Limited] |
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| March 20 – March 25
Vienna, Austria |
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| | University of California San Francisco – San Francisco, California, United States |
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| Babraham Institute – Babraham, Cambridgeshire, United Kingdom |
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| | University of Washington – Seattle, Washington, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | Wayne State University School of Medicine – Detroit, Michigan, United States |
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