 | | Vol. 11.08 – 3 March, 2022 |
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| Scientists revealed that S protein glycosylation had site-differential effects on viral infectivity and found that S protein generated by lung epithelial cells had glycoforms associated with increased infectivity.
[Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that TLR4 signaling in vascular endothelial cells and downstream NADPH oxidase 4 expression mediated the arrest of neutrophils, a step upstream of their extravasation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Usp38−/− mice were more susceptible to inflammatory damage and death and developed more serious pulmonary fibrosis after bleomycin treatment.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors identified an interferon-γ-regulated subset of monocytes, CCR2+ monocytes, as a driver of lung damage during influenza A virus infection.
[Cell Reports] |
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| STAT3 inhibition effectively suppressed the adaptive survival of anaplastic lymphoma kinase (ALK)-rearranged lung cancer cells by enhancing ALK inhibition-induced apoptosis.
[npj Precision Oncology] |
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| Researchers reported a novel blood-based biomarker panel for early diagnosis, monitoring of therapeutic response, and prognostic evaluation of patients with NSCLC brain metastasis.
[British Journal of Cancer] |
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| Pharmacologic inhibition of mTOR kinase by Torin2 significantly sensitized lung squamous cell carcinoma cell lines to ionizing radiation.
[Molecular Cancer Research] |
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| Investigators unveiled the mechanism underlying long intergenic nonprotein coding RNA 0649 (LINC00649) in lung squamous cell carcinoma (LUSC) cells. As a result, LINC00649 was discovered to be with high expression in LUSC cells.
[Cancer Gene Therapy] |
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| The effects of ALAHM on hepatocyte paracrine HGF as well as proliferation, invasion, and migration of lung adenocarcinoma cells were observed in vitro.
[iScience] |
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| Researchers suggested that H5N1 virus infection impaired the alveolar epithelial barrier by downregulating the expression of intercellular junction proteins at the posttranslational level.
[Communications Biology] |
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| MiR-146a alleviated lung injury caused by respiratory syncytial virus (RSV) infection in young rats by targeting TRAF-6 and regulating JNK/ERK/MAPK signaling pathways.
[Scientific Reports] |
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| Scientists appraise current literature, opportunities, and challenges associated with liquid biopsy and pharmacogenomic testing as precision therapy tools in the management of epidermal growth factor receptor (EGFR) mutant and resistant lung cancers.
[Molecular Cancer] |
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| The authors take stock of the relationship between epidermal growth factor receptor (EGFR) mutations and PD-1 and its ligand receptor 1 expression and summarize the important clinical studies on immunotherapy-inhibitor-based treatment in patients with EGFR-tyrosine kinase inhibitor-resistant NSCLC.
[Future Oncology] |
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| Genprex, Inc. announced that the first patient was dosed in the Acclaim-1 clinical trial, an open-label, multi-center Phase I/II clinical trial evaluating REQORSA™ Immunogene Therapy, in combination with Tagrisso® (osimertinib) in patients with late-stage NSCLC.
[Genprex, Inc.] |
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| AnHeart Therapeutics together with Innovent Biologics, Inc. jointly announced that the Center for Drug Evaluation of China’s Nation Medical Products Administration (NMPA) has granted Breakthrough Therapy Designation to taletrectinib.
[AnHeart Therapeutics] |
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| April 8 – 13, 2022
New Orleans, Louisiana, United States |
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| | King’s College London – London, United Kingdom |
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| | University of California San Francisco – San Francisco, California, United States |
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| Babraham Institute – Babraham, Cambridgeshire, United Kingdom |
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| | University of Washington – Seattle, Washington, United States |
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| | Wayne State University School of Medicine – Detroit, Michigan, United States |
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