 | | Vol. 11.09 – 10 March, 2022 |
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| Investigators focused on the neuroendocrine SCLC subtypes, SCLC-A and SCLC-N, whose transcription addiction was driven by ASCL1 and NEUROD1 transcription factors which targeted E-box motifs to activate up to 40% of total genes.
[EMBO Molecular Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated the epithelial cell response to B. pertussis infection in primary human airway epithelium differentiated at air–liquid interface.
[Scientific Reports] |
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| The authors explored the anti-inflammatory effects and underlying molecular mechanism of povidone-iodine (PVP-I) on lipopolysaccharide-stimulated airway epithelial cells and investigated whether nasal instillation of PVP-I could suppress mucosal inflammation in non-eosinophilic chronic rhinosinusitis mice.
[Scientific Reports] |
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| Investigators sought to measure respiratory syncytial virus (RSV) replication, cytopathic effects, and protein expression in human lung organoids reproducing architecture and transcriptional profiles of human fetal lungs during the first trimester of gestation.
[PLoS One] |
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| Researchers indicated that circ_0001679/miR-338-3p/MAPK1 axis may have played an important role in the pathogenesis of acute lung injury.
[Bioengineered] |
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| Investigators evaluated the distribution of MUC5AC and MUC5B in bronchiolar adenoma/ciliated muconodular papillary tumor for comparison with that seen in normal respiratory tract.
[Pathology International] |
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| Scientists analyzed the regulatory relationship of hypoxia and PVT1 and the mechanism of PVT1 in the hypoxia-induced chemoresistance process of lung cancer.
[Cell Death Discovery] |
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| Investigators verified that the cell proliferation, colony formation, migration, and invasion of lung adenocarcinoma could be inhibited by the knockdown of long intergenic nonprotein coding RNA 518 (LINC00518).
[Cell Death Discovery] |
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| The effects of small proline rich protein 1A (SPRR1A) on lung cancer cells were tested through cellular experiments and the result demonstrated that knockdown of SPRR1A could suppress proliferation and invasion capacities of tumor cells, while overexpressing SPRR1A exerted opposite effects.
[Biochemistry and Cell Biology] |
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| NF-ĸB transcriptional activity was found to be stimulated with CALR overexpression and reduced in CALR-deficient lung cancer cells, thereby clearly indicating CALR-dependent NF-ĸB activation.
[Bioengineered] |
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| The authors summarize the main clinical applications of liquid biopsy in advanced NSCLC, underlining both its potential and limitations from a clinically driven perspective.
[British Journal of Cancer] |
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| Scientists pave the way for introducing a panel of miRNAs for the prediction of tyrosine kinase inhibitors responses in lung cancer patients.
[Journal of Cell Communication and Signaling] |
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| Harpoon Therapeutics, Inc. announced that the US FDA has granted Orphan Drug Designation for HPN328, a delta like ligand 3-targeting TriTAC®, for the treatment of SCLC.
[Harpoon Therapeutics, Inc.] |
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| HUTCHMED announced that it has received a US$15 million milestone payment from AstraZeneca PLC.
[HUTCHMED] |
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| | Berlin Institute of Health – Berlin, Germany |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | King’s College London – London, England, United Kingdom |
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| | University of California San Francisco – San Francisco, California, United States |
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| | University of Washington – Seattle, Washington, United States |
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