Pulmonary Cell News Volume 11.10 | Mar 17 2022

May 12, 2022

2022-03-16 | PULCN 11.10

Pulmonary Cell News by STEMCELL Technologies

Vol. 11.10 – 17 March, 2022

TOP STORY

Malfunction of Airway Basal Stem Cells Plays a Crucial Role in Pathophysiology of Tracheobronchopathia Osteoplastica

Scientists revealed a role of airway basal cells in tracheobronchopathia osteochondroplastica progression by acting as a repository of inflammatory and TGFβ-BMP signals, which contributed to both epithelial metaplasia and mesenchymal osteo-chondrogenesis via extracellular signaling and matrix remodeling.
[Nature Communications]

Full Article

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The Arginine Methyltransferase PRMT7 Promotes Extravasation of Monocytes Resulting in Tissue Injury in COPD

Researchers showed that in COPD patients, protein arginine methyltransferase 7 (PRMT7) expression was elevated in the lung tissue and localized to the macrophages.
[Nature Communications]

Full Article

Airway Secretory Cell Fate Conversion via YAP-mTORC1-Dependent Essential Amino Acid Metabolism

The authors demonstrated that YAP/TAZ activation reprogrammed airway secretory cells, which subsequently lost their cellular identity and acquired squamous alveolar type 1 fate in the lung.
[EMBO Journal]

Full Article Graphical Abstract

hnRNP L-Activated circANKRD42 Reverse Splicing and the circANKRD42-Mediated Crosstalk between Mechanical Stiffness and Biochemical Signals to Drive Pulmonary Fibrogenesis

Investigators identified a novel circular RNA (circRNA)-ANKRD42 from peripheral blood of patients with idiopathic pulmonary fibrosis, which participated in pulmonary fibrosis through the close communication of mechanical stiffness and biochemical signals.
[Molecular Therapy]

Abstract Graphical Abstract

Pulmonary Fibrosis Model Using Micro-CT Analyzable Human PSC–Derived Alveolar Organoids Containing Alveolar Macrophage-Like Cells

Researchers suggested that micro-computed tomography (CT) analyzable pluripotent stem cell (PSC)-derived alveolar human lung organoids were a promising in vitro model to predict lung toxicity manifestations, including fibrosis.
[Cell Biology and Toxicology]

Full Article Graphical Abstract

COPD Is Associated with Epigenome-Wide Differential Methylation in BAL Lung Cells

To assess methylation profiles in the main COPD target organ, investigators performed an epigenome-wide association study on bronchoalveolar lavage cells.
[American Journal of Respiratory Cell and Molecular Biology]

Abstract

Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus

The authors established, from single biopsy specimens, a human adult stem cell-derived organoid model representing the upper respiratory airways and lungs and explored the applicability of this model to study respiratory virus infection.
[Frontiers in Cellular and infection Microbiology]

Full Article

LUNG CANCER

GSK3 Inhibition Circumvents and Overcomes Acquired Lorlatinib Resistance in ALK-Rearranged Non-Small-Cell Lung Cancer

Scientists established lorlatinib intermediate resistant cells from a patient-derived cell model. Glycogen synthase kinase 3 (GSK3) inhibitions significantly suppressed lorlatinib intermediate resistant cell growth.
[npj Precision Oncology]

Full Article

Vascularized Lung Cancer Model for Evaluating the Promoted Transport of Anticancer Drugs and Immune Cells in an Engineered Tumor Microenvironment

The authors presented a method for inducing controlled tumor angiogenesis by engineering the microenvironment that could aid in the development of effective anticancer drugs and cancer immunotherapy.
[Advanced Healthcare Materials]

Abstract Full Article

The Small Molecule Chemical Compound Cinobufotalin Attenuates Resistance to DDP by Inducing ENKUR Expression to Suppress MYH9-Mediated C-Myc Deubiquitination in Lung Adenocarcinoma

Scientists found that cinobufotalin (CB) decreased cisplatin (DDP) resistance, migration and invasion in lung adenocarcinoma and showed that CB induced ENKUR expression by suppressing PI3K/AKT signaling to downregulate c-Jun, a negative transcription factor of ENKUR.
[Acta Pharmacologica Sinica]

Abstract

Multi-Omic Alterations of the SWI/SNF Complex Define a Clinical Subgroup in Lung Adenocarcinoma

Investigators combined multiple “-omics” methods to assess SWI/SNF composition and aberrations in lung adenocarcinoma (LUAD). Mutations in lung SWI/SNF subunits were highly recurrent in their LUAD cohort, and over 70% of the mutations were predicted to have functional impact.
[Clinical Epigenetics]

Full Article

Identifying Metabolic Reprogramming Phenotypes with Glycolysis-Lipid Metabolism Discoordination and Intercellular Communication for Lung Adenocarcinoma Metastasis

Researchers explored the metabolic reprogramming relevant to lung adenocarcinoma metastasis and decoded the underlying intercellular alterations.
[Communications Biology]

Full Article

AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC through Expansion of TCF1⁺ CD8 T Cells

Investigators demonstrated that AXL was a critical targetable driver of immune suppression in STK11/LKB1 mutant NSCLC.
[Cell Reports Medicine]

Full Article Graphical Abstract

REVIEWS

Small Cell Lung Cancer Transformation: From Pathogenesis to Treatment

The authors review the advancements in transformed SCLC, including clinical and pathological characteristics, and the potential effective treatment after SCLC transformation, aiming to give a better understanding of transformed SCLC and provide support for clinical uses.
[Seminars in Cancer Biology]

Abstract

Ferroptosis, Necroptosis, and Pyroptosis in the Tumor Microenvironment: Perspectives for Immunotherapy of SCLC

Scientists summarize the roles of distinct immunogenic cell death mechanisms on antitumor immunity and recent advances of ferroptosis-, necroptosis- and pyroptosis-inducing agents, and present perspectives on these cell death mechanisms in immunotherapy of SCLC.
[Seminars in Cancer Biology]

Abstract

CAR-T Cell Therapy for Lung Cancer: Potential and Perspective

Investigators outline the basic structure and generation characteristic of chimeric antigen receptor-modified T (CAR-T) cells and summarize the common tumor-associated antigens in clinical trials of CAR-T cell therapy for lung cancer.
[Thoracic Cancer]

Full Article

INDUSTRY AND POLICY NEWS

US FDA Approves FoundationOne^®CDx as a Companion Diagnostic for EGFR Therapeutics Targeting Exon 19 Deletions or Exon 21 Substitutions in Non-Small Cell Lung Cancer

Foundation Medicine, Inc. announced it has received approval from the US FDA for FoundationOne^®CDx to be used as a companion diagnostic to identify patients with NSCLC.
[Foundation Medicine, Inc.]

Press Release

Iovance Biotherapeutics’ Investigational New Drug Application (IND) Allowed to Proceed for TALEN^®-Edited Tumor Infiltrating Lymphocyte (TIL) in Unresectable or Metastatic Melanoma and Stage III or IV Non-Small Cell Lung Cancer (NSCLC)

Iovance Biotherapeutics, Inc. announced that the US FDA has allowed an IND to proceed for its first genetically modified TIL therapy, IOV-4001, for the treatment of unresectable or metastatic melanoma and stage III or IV NSCLC.
[Iovance Biotherapeutics, Inc.]

Press Release

FEATURED EVENT

Malfunction of Airway Basal Stem Cells Plays a Crucial Role in Pathophysiology of Tracheobronchopathia Osteoplastica

The Arginine Methyltransferase PRMT7 Promotes Extravasation of Monocytes Resulting in Tissue Injury in COPD

Airway Secretory Cell Fate Conversion via YAP-mTORC1-Dependent Essential Amino Acid Metabolism

hnRNP L-Activated circANKRD42 Reverse Splicing and the circANKRD42-Mediated Crosstalk between Mechanical Stiffness and Biochemical Signals to Drive Pulmonary Fibrogenesis

Pulmonary Fibrosis Model Using Micro-CT Analyzable Human PSC–Derived Alveolar Organoids Containing Alveolar Macrophage-Like Cells

COPD Is Associated with Epigenome-Wide Differential Methylation in BAL Lung Cells

Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus

GSK3 Inhibition Circumvents and Overcomes Acquired Lorlatinib Resistance in ALK-Rearranged Non-Small-Cell Lung Cancer

Vascularized Lung Cancer Model for Evaluating the Promoted Transport of Anticancer Drugs and Immune Cells in an Engineered Tumor Microenvironment

The Small Molecule Chemical Compound Cinobufotalin Attenuates Resistance to DDP by Inducing ENKUR Expression to Suppress MYH9-Mediated C-Myc Deubiquitination in Lung Adenocarcinoma

Multi-Omic Alterations of the SWI/SNF Complex Define a Clinical Subgroup in Lung Adenocarcinoma

Identifying Metabolic Reprogramming Phenotypes with Glycolysis-Lipid Metabolism Discoordination and Intercellular Communication for Lung Adenocarcinoma Metastasis

AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC through Expansion of TCF1⁺ CD8 T Cells

Small Cell Lung Cancer Transformation: From Pathogenesis to Treatment

Ferroptosis, Necroptosis, and Pyroptosis in the Tumor Microenvironment: Perspectives for Immunotherapy of SCLC

CAR-T Cell Therapy for Lung Cancer: Potential and Perspective

US FDA Approves FoundationOne^®CDx as a Companion Diagnostic for EGFR Therapeutics Targeting Exon 19 Deletions or Exon 21 Substitutions in Non-Small Cell Lung Cancer

Iovance Biotherapeutics’ Investigational New Drug Application (IND) Allowed to Proceed for TALEN^®-Edited Tumor Infiltrating Lymphocyte (TIL) in Unresectable or Metastatic Melanoma and Stage III or IV Non-Small Cell Lung Cancer (NSCLC)

32^nd European Congress of Clinical Microbiology & Infectious Diseases

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Principal Scientific Researcher – Cell and Tissue Genomics

Senior Associate Scientist – Biology

Faculty Position – Lung Cancer

Postdoctoral Position – Human Disease Models

Postdoctoral Position – Vascular Biology

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