Pulmonary Cell News Volume 11.11 | Mar 24 2022

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    2022-03-24 | PULCN 11.11


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.11 – 24 March, 2022
    TOP STORY

    A Transcriptomics-Guided Drug Target Discovery Strategy Identifies Receptor Ligands for Lung Regeneration

    Scientists used a transcriptomics-guided drug target discovery strategy using gene signatures of smoking-associated COPD and from mice chronically exposed to cigarette smoke, identifying druggable targets expressed in alveolar epithelial progenitors, of which they screened the function in lung organoids.
    [Science Advances]

    Full Article
    Watch this webinar to learn the advantages of using primary human nasal epithelial cells to study Cystic Fibrosis.
    PUBLICATIONSRanked by the impact factor of the journal

    Inhibition of Lung Microbiota-Derived Proapoptotic Peptides Ameliorates Acute Exacerbation of Pulmonary Fibrosis

    Researchers demonstrated that an anticorisin monoclonal antibody ameliorated lung fibrosis by significantly inhibiting acute exacerbation in the human transforming growth factorβ1 model and acute lung injury in the bleomycin model.
    [Nature Communications]

    Full ArticlePress Release

    Cigarette Smoking Is a Secondary Cause of Folliculin Loss

    Given that COPD often shares structural features with Birt-Hogg-Dubé syndrome, scientists investigated the link between COPD, cigarette smoke exposure and folliculin gene expression.
    [Thorax]

    Full Article

    Allelic Imbalance of HLA-B Expression in Human Lung Cells Infected with Coronavirus and Other Respiratory Viruses

    Investigators discovered an increased allelic expression pattern accompanied by overexpression of human leucocyte antigen (HLA)-B gene in SARS-CoV-2-infected human lung epithelial cells.
    [European Journal of Human Genetics]

    Full Article

    ARAF Suppresses ERBB3 Expression and Metastasis in a Subset of Lung Cancers

    Researchers uncovered that the depletion of ARAF promoted anchorage-independent growth and metastasis through activation of AKT signaling in a subset of lung cancer cells.
    [Science Advances]

    Full Article

    The Glucocorticoid Receptor Associates with RAS Complexes to Inhibit Cell Proliferation and Tumor Growth

    The authors found that glucocorticoid receptor was present in cytoplasmic KRAS-containing complexes and inhibited the activation of wild-type and oncogenic KRAS in mouse embryonic fibroblasts and human lung cancer A549 cells.
    [Science Signaling]

    Abstract

    m6A Demethylase ALKBH5 Promotes Tumor Cell Proliferation by Destabilizing IGF2BPs Target Genes and Worsens the Prognosis of Patients with Non-Small-Cell Lung Cancer

    Scientists revealed that the expression of AlkB homolog 5 (ALKBH5) was increased in NSCLC and increased expression of ALKBH5 worsened the prognosis of patients with NSCLC.
    [Cancer Gene Therapy]

    Full Article

    Exon Skipping Induced by CRISPR-Directed Gene Editing Regulates the Response to Chemotherapy in Non-Small Cell Lung Carcinoma Cells

    The authors reported how nuclear factor erythroid 2-related factor 2 disruption led to collateral damage in the form of CRISPR-mediated exon skipping.
    [Gene Therapy]

    Full ArticlePress Release

    Claudin1 Decrease Induced by 1,25-Dihydroxy-Vitamin D3 Potentiates Gefitinib Resistance Therapy through Inhibiting AKT Activation-Mediated Cancer Stem-Like Properties in NSCLC Cells

    Researchers performed GEO dataset analysis and identified that claudin1 was a critical regulator of epidermal growth factor receptor tyrosine kinase inhibitors resistance in NSCLC cells.
    [Cell Death Discovery]

    Full Article

    Targeting Lung Cancer Cells with MUC1 Aptamer-Functionalized PLA-PEG Nanocarriers

    Physiochemical properties, encapsulation efficiency, loading content and in vitro release kinetics of doxorubicin were assessed in Mucin 1 (MUC1) aptamer-functionalized PLA-PEG nanocarriers targeting lung cancer cells.
    [Scientific Reports]

    Full Article
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    Role of Air Pollutants in Airway Epithelial Barrier Dysfunction in Asthma and COPD

    The authors discuss the molecular and immunological mechanisms involved in physical barrier disruption induced by major airborne pollutants and outline their implications in the pathogenesis of asthma and COPD.
    [European Respiratory Review]

    Full Article

    The Pathological Maelstrom of COVID-19 and Cardiovascular Disease

    Involvement of the cardiovascular system in COVID-19 has important consequences during recovery from infection and the development of long COVID.
    [Nature Cardiovascular Research]

    Full Article
    INDUSTRY AND POLICY NEWS

    Windtree Announces Results from Its Phase II Study of Lucinactant for COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS) and Lung Injury

    Windtree Therapeutics, Inc. announced results from its Phase II study of lucinactant for patients with severe COVID-19 associated ARDS and lung injury.
    [Windtree Therapeutics, Inc.]

    Press Release

    Lung Therapeutics Announces Successful Completion of Phase Ia Clinical Trial of LTI-03 in Healthy Volunteers

    Lung Therapeutics, Inc. announced the successful completion of a Phase Ia clinical trial for LTI-03, a Caveolin-1-related peptide designed to treat idiopathic pulmonary fibrosis.
    [Lung Therapeutics, Inc]

    Press Release
    FEATURED EVENT

    3rd Immuno-Metabolic Mechanisms of Atherosclerosis Conference

    May 1 – 4, 2022
    Riviera Maya, Mexico

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Acute Lung Injury

    University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States

    Principal Scientific Researcher – Cell and Tissue Genomics

    Genentech, Inc. – South San Francisco, California, United States

    Senior Associate Scientist – Biology

    Gilead Sciences – Foster City, California, United States

    Faculty Position – Lung Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Postdoctoral Position – Human Disease Models

    Berlin Institute of Health – Berlin, Germany

    > See All Jobs

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