Pulmonary Cell News Volume 11.13 | Apr 7 2022

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    2022-04-07 | PULCN 11.13


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.13 – 7 April, 2022
    TOP STORY

    Hedgehog-Responsive PDGFRa(+) Fibroblasts Maintain a Unique Pool of Alveolar Epithelial Progenitor Cells during Alveologenesis

    Scientists showed that during alveologenesis, Hedgehog-responsive PDGFRa(+) progenitors were a source of secreted trophic molecules that maintained a unique lung alveolar type 2 progenitor population.
    [Cell Reports]

    Full ArticleGraphical Abstract
    Enjoy your weekend. Your cells will too. Reduce medium acidosis with mTeSRâ„¢ Plus.
    PUBLICATIONSRanked by the impact factor of the journal

    Inhibition of SARS-CoV-2 Replication in the Lung with siRNA/VIPER Polyplexes

    Researchers developed a formulation for pulmonary administration of siRNA to suppress SARS-CoV-2 replication in lung epithelial cells.
    [Journal of Controlled Release]

    Full ArticlePress ReleaseGraphical Abstract

    USP28 Enables Oncogenic Transformation of Respiratory Cells and Its Inhibition Potentiates Molecular Therapy Targeting Mutant EGFR, BRAF and PI3K.

    Targeting ubiquitin carboxyl-terminal hydrolase 28 (USP28) protein abundance at an early stage via inhibition of its activity was a feasible strategy for the treatment of early-stage lung tumors.
    [Molecular Oncology]

    AbstractFull Article

    Lipidomic Profiling of Bronchoalveolar Lavage Fluid Extracellular Vesicles Indicates Their Involvement in Lipopolysaccharide-Induced Acute Lung Injury

    Extracellular vesicles released during acute lung injury originated from alveolar epithelial cells, macrophages, and neutrophils and carry a diverse array of lipid mediators derived from ω-3 and ω-6 polyunsaturated fatty acids.
    [Journal of Innate Immunity]

    Full Article

    27-Hydroxycholesterol Linked High Cholesterol Diet to Lung Adenocarcinoma Metastasis

    The authors evidenced that cholesterol promoted cell proliferation and invasion of lung adenocarcinoma (LAC) in vitro as well as LAC metastasis in vivo.
    [Oncogene]

    Full Article

    SIX5-Activated LINC01468 Promotes Lung Adenocarcinoma Progression by Recruiting SERBP1 to Regulate SERPINE1 mRNA Stability and Recruiting USP5 to Facilitate PAI1 Protein Deubiquitylation

    Rescue experiments verified LINC01468 modulated proliferation, migration and invasion of lung adenocarcinoma cells via upregulation of SERPINE1.
    [Cell Death & Disease]

    Full Article

    LncRNA HOXC-AS3 Promotes Non-Small-Cell Lung Cancer Growth and Metastasis through Upregulation of YBX1

    The authors explored the molecular mechanisms underlying NSCLC development, focusing on the HOXC-AS3/YBX1/HOXC8 axis.
    [Cell Death & Disease]

    Full Article

    Promoter Methylation-Regulated miR-148a-3p Inhibits Lung Adenocarcinoma (LUAD) Progression by Targeting MAP3K9

    Investigators demonstrated that mitogen-activated protein (MAP) kinase kinase kinase 9 (MAP3K9) was the target of miR-148a-3p and that MAP3K9 levels were significantly increased in both lung adenocarcinoma cell lines and clinical tumor tissues.
    [Acta Pharmacologica Sinica]

    Abstract

    Vestigial-Like Family Member 3 Stimulates Cell Motility by Inducing High-Mobility Group AT-Hook 2 Expression in Cancer Cells

    Scientists found that A549 human lung cancer cells stably expressing vestigial-like family member 3 exhibited spindle-like morphological changes, reduction in the epithelial marker E-cadherin and induction of the mesenchymal marker Snail.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Betacellulin Promotes Tumor Development and EGFR Mutant Lung Cancer Growth by Stimulating the EGFR Pathway and Suppressing Apoptosis

    Knockdown of betacellulin inhibited the growth of EGFR-mutant human lung adenocarcinoma cells in culture and their tumor-forming ability in mice.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Targeting Nicotinamide N-Methyltransferase Overcomes Resistance to EGFR-TKI in Non-Small Cell Lung Cancer Cells

    Using iTRAQ-based quantitative proteomics analysis, we identified that nicotinamide N-methyltransferase was significantly increased in epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-resistant NSCLC cells.
    [Cell Death Discovery]

    Full Article

    Elevated BTG2 Improves the Radiosensitivity of Non-small Cell Lung Cancer (NSCLC) through Apoptosis

    Scientists identified radio-responsive genes and explored the biological function of encoded proteins in NSCLC.
    [Thoracic Cancer]

    Full Article

    The miR-4732-5p/XPR1 Axis Suppresses the Invasion, Metastasis, and Epithelial–Mesenchymal Transition of Lung Adenocarcinoma via the PI3K/Akt/GSK3β/Snail Pathway

    Overexpression of miR-4732-5p significantly inhibited the migration, invasion, and metastasis of lung adenocarcinoma in vitro and in vivo, which could be reversed by overexpression of xenotropic and polytropic retrovirus receptor 1 (XPR1).
    [Molecular Omics]

    AbstractGraphical Abstract
    Virtual Conference Exhibition: Organoids
    REVIEWS

    Targeting lncRNAs in Programmed Cell Death as a Therapeutic Strategy for Non-Small Cell Lung Cancer

    The authors focus on the function of lncRNAs in programmed cell death (PCD) of NSCLC and summarize the therapeutic role of targeting lncRNAs in PCD for NSCLC treatment
    [Cell Death Discovery]

    Full Article

    Physical Activity in Surgical Lung Cancer Patients: A Systematic Review

    Scientists suggest that physical activity is low among surgical lung cancer patients, and it might not recover within three months following surgery and that physical activity has the potential to improve postoperative outcomes.
    [Supportive Care in Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Blade Therapeutics Announces Feedback from FDA on End-of-Phase I Data Package

    Blade Therapeutics, Inc. announced receipt of feedback from the FDA regarding the company’s end-of-Phase I data package for cudetaxestat, an investigational non-competitive autotaxin inhibitor in clinical development for treatment of idiopathic pulmonary fibrosis and other fibrotic diseases.
    [Blade Therapeutics, Inc.]

    Press Release

    Janssen Announces Health Canada Approval of RYBREVANT® (amivantamab), the First and Only Targeted Treatment for Patients with Non-Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations

    The Janssen Pharmaceutical Companies of Johnson & Johnson announced that Health Canada has issued a Notice of Compliance with Conditions approving RYBREVANT®, a fully-human, bispecific antibody, for the treatment of adult patients with locally advanced or metastatic NSCLC.
    [Janssen Pharmaceutical Companies]

    Press Release
    FEATURED EVENT

    EMBO Workshop: New Approaches to Combat Antibiotic-Resistant Bacteria

    June 12 – 16, 2022
    Ascona, Switzerland

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Resistance in Small Cell Lung Cancer

    Medical Center Cologne – Cologne, Germany

    Postdoctoral Scholar – Translational Lung Cancer

    The Ohio State University – Columbus, Ohio, United States

    Postdoctoral Associate – Acute Lung Injury

    University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States

    Principal Scientific Researcher – Cell and Tissue Genomics

    Genentech, Inc. – South San Francisco, California, United States

    Senior Associate Scientist – Biology

    Gilead Sciences – Foster City, California, United States

    > See All Jobs

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