Pulmonary Cell News Volume 11.14 | Apr 14 2022

May 12, 2022

2022-04-14 | PULCN 11.14

Pulmonary Cell News by STEMCELL Technologies

Vol. 11.14 – 14 April, 2022

TOP STORY

Single-Cell Analysis of Somatic Mutations in Human Bronchial Epithelial Cells in Relation to Aging and Smoking

Scientists applied single-cell whole-genome sequencing of proximal bronchial basal cells from 33 participants aged between 11 and 86 years with smoking histories varying from never-smoking to 116 pack-years.
[Nature Genetics]

Abstract Press Release

PUBLICATIONSRanked by the impact factor of the journal

Progenitor Potential of Lung Epithelial Organoid Cells in a Transplantation Model

The authors transplanted organoid cells derived from alveolar type II cells enriched by SCA1-negative status or multipotent SCA1-positive progenitor cells into injured mouse lungs.
[Cell Reports]

Full Article Graphical Abstract

Caspase-9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis

A transgenic mouse model expressing human Caspase-9b in the lung pneumocytes developed inflammatory lung lesions, which correlated with enhanced activation of the NF-κB pathway and increased influx of immunosuppressive MDSCs in contrast to wild-type mice.
[Molecular Cancer Research]

Abstract

LUNG CANCER

Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non-Small Cell Lung Cancer

A retrospective database query identified patients with KRAS-mutant NSCLC to understand their propensity to develop brain metastases.
[Clinical Cancer Research]

Abstract

Cancer Stem-Like Cells Evade CD8⁺CD103⁺ Tumor-Resident Memory T (T_RM) Lymphocytes by Initiating an Epithelial-to-Mesenchymal Transition Program in a Human Lung Tumor Mode

Researchers supported the rational design of immunotherapeutic strategies targeting cancer stem cells to optimize their responsiveness to local CD8⁺CD103⁺ T_RM cells for more efficient anticancer treatments.
[Journal For Immunotherapy of Cancer]

Full Article

Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET

The authors identified that the loss of an epigenetic factor, lysine methyltransferase 5C (KMT5C), drove resistance of NSCLC to multiple EGFR inhibitors, including erlotinib, gefitinib, afatinib, and osimertinib.
[Cancer Research]

Abstract

LncRNA PCAT1 Activates SOX2 and Suppresses Radioimmune Responses via Regulating cGAS/STING Signaling in Non-Small Cell Lung Cancer

Investigators explored the impacts of prostate cancer-associated ncRNA transcripts 1 (PCAT1) on tumorigenesis and radioimmune responses and the underlying molecular mechanisms in NSCLC.
[Clinical and Translational Medicine]

Full Article

Long Noncoding RNA SH3PXD2A-AS1 Promotes NSCLC Proliferation and Accelerates Cell Cycle Progression by Interacting with DHX9

The authors found that SH3PXD2A-AS1 expression in NSCLC tissues was upregulated compared with that in normal lung tissues in The Cancer Genome Atlas database by using the GEPIA website.
[Cell Death Discovery]

Full Article

Circ_0004140 Promotes LUAD Tumor Progression and Immune Resistance through circ_0004140/miR-1184/CCL22 Axis

Researchers identified a novel circular RNA (circ_0004140), derived from the oncogene YAP1, which was up-regulated in lung adenocarcinoma (LUAD). The high expression of circ_0004140 was correlated with poor prognosis and cytotoxic T-lymphocyte cells dysfunction in LUAD patients.
[Cell Death Discovery]

Full Article

REVIEWS

Incidental Discovery of Interstitial Lung Disease: Diagnostic Approach, Surveillance and Perspectives

Scientists focus on some of the limits of the current approach, underlying the potential for progression to full-blown interstitial lung disease of some patients with interstitial lung abnormalities (ILA) and the numerous links between subpleural fibrotic ILA and idiopathic pulmonary fibrosis.
[European Respiratory Review]

Full Article

EGFR Exon 20 Insertion Mutations in Advanced Non-Small-Cell Lung Cancer: Current Status and Perspectives

The authors systematically review the recent clinical research and treatments used for epidermal growth factor receptor EGFR exon 20 insertion mutations, summarize the latest data on emerging therapies, and discuss future prospects and treatments.
[Biomarker Research]

Full Article

INDUSTRY AND POLICY NEWS

IO Biotech Announces Initiation of Phase II Trial of IO102-IO103 in Combination With KEYTRUDA^® (pembrolizumab) as First-Line Treatment in a Multi-Arm Basket Trial

IO Biotech, a clinical-stage biopharmaceutical company developing immune-modulating cancer therapies based on its T-win^® technology platform, announced that it has dosed the first patient, in metastatic NSCLC, in its Phase II IOB-022 / KN-D38 trial.
[IO Biotech]

Press Release

Coherus and Junshi Biosciences Announce PD-1 Inhibitor Toripalimab Granted Orphan Drug Designation for Small Cell Lung Cancer in the United States

Coherus BioSciences, Inc. announced that the FDA has granted Orphan Drug Designation for toripalimab, a PD-1 inhibitor, for the treatment of small cell lung cancer.
[Coherus BioSciences, Inc.]

Press Release

FEATURED EVENT

Single-Cell Analysis of Somatic Mutations in Human Bronchial Epithelial Cells in Relation to Aging and Smoking

Progenitor Potential of Lung Epithelial Organoid Cells in a Transplantation Model

Caspase-9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis

Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non-Small Cell Lung Cancer

Cancer Stem-Like Cells Evade CD8⁺CD103⁺ Tumor-Resident Memory T (T_RM) Lymphocytes by Initiating an Epithelial-to-Mesenchymal Transition Program in a Human Lung Tumor Mode

Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET

LncRNA PCAT1 Activates SOX2 and Suppresses Radioimmune Responses via Regulating cGAS/STING Signaling in Non-Small Cell Lung Cancer

Long Noncoding RNA SH3PXD2A-AS1 Promotes NSCLC Proliferation and Accelerates Cell Cycle Progression by Interacting with DHX9

Circ_0004140 Promotes LUAD Tumor Progression and Immune Resistance through circ_0004140/miR-1184/CCL22 Axis

Incidental Discovery of Interstitial Lung Disease: Diagnostic Approach, Surveillance and Perspectives

EGFR Exon 20 Insertion Mutations in Advanced Non-Small-Cell Lung Cancer: Current Status and Perspectives

IO Biotech Announces Initiation of Phase II Trial of IO102-IO103 in Combination With KEYTRUDA^® (pembrolizumab) as First-Line Treatment in a Multi-Arm Basket Trial

Coherus and Junshi Biosciences Announce PD-1 Inhibitor Toripalimab Granted Orphan Drug Designation for Small Cell Lung Cancer in the United States

ISSCR 2022 Annual Meeting

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Research Chair – Lung Regenerative Medicine

Postdoctoral Fellow – Resistance in Small Cell Lung Cancer

Postdoctoral Scholar – Translational Lung Cancer

Postdoctoral Associate – Acute Lung Injury

Principal Scientific Researcher – Cell and Tissue Genomics

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