 | | Vol. 11.15 – 21 April, 2022 |
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| Investigators reported that chimeric antigen receptor (CAR) T cells targeting B7-H3 exhibited antitumor activity in vitro against tumor cell lines and lung cancer organoids, and in vivo in xenotransplant models of orthotopic and metastatic NSCLC.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers established a lung and macrophage co-culture system derived from human pluripotent stem cells, modeling the host-pathogen interaction in SARS-CoV-2 infection.
[Nature Communications] |
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| The authors showed that neonatal-derived pulmonary SSEA-1+ cells highly expressed lung development-associated genes and had enhanced organoid generation ability compared with the adult cells.
[iScience] |
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| Scientists suggested that circHECTD1 inhibited the apoptosis of alveolar epithelial cells through miR-320a/PIK3CA and miR-136/Sirt1 pathways in lipopolysaccharide-induced acute lung injury.
[Laboratory Investigation] |
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| Researchers provided evidence that hiNeuroS-TRAIL cells could migrate to and suppress growth of NSCLC metastases in combination with radiation.
[Stem Cell Reviews and Reports] |
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| Investigators evaluated the therapeutic potential of the novel SHP2 degrader, SHP2-D26, either alone or in combination, against NSCLC cells.
[Cancer Gene Therapy] |
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| Survival rates were estimated by the Kaplan–Meier method with log-rank statistics. Lung cancer organoids were generated from patient-derived malignant pleural effusion to perform drug sensitivity assays.
[Thoracic Cancer] |
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| CircRNA ataxin 7 (circATXN7) accelerated the malignancy of NSCLC cells through adsorbing miR-7-5p and upregulating profilin 2.
[Thoracic Cancer] |
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| To understand the molecular mechanisms underlying SCLC metastasis, the authors generated SCLC mouse models with orthotopically transplanted genome-edited lung organoids and performed multiomics analyses.
[Nature Cancer] |
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| Investigators summarize the latest research on the diagnosis of early-stage NSCLC via liquid biopsy, including circulating DNA, circulating tumor cells, exosomes, and tumor-educated platelets.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
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| Scientists provide an overview of sintilimab-based clinical trials on NSCLC, and support further investigation of sintilimab in future clinical trials.
[Biomarker Research] |
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| The authors systematically evaluate the diagnostic value of portable spirometers in detecting COPD.
[NPJ Primary Care Respiratory Medicine] |
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| Atossa Therapeutics, Inc. has completed enrolling participants in Part B of its Phase I/IIa clinical study of AT-H201 in Australia, which is being developed as an inhalation therapy for moderately to severely ill hospitalized COVID-19 patients and for “long-haul” patients.
[Atossa Therapeutics, Inc.] |
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| Black Diamond Therapeutics, Inc. announced the dosing of the first patient in the Phase I study evaluating BDTX-1535, a MasterKey inhibitor of epidermal growth factor receptor (EGFR) for the treatment of both NSCLC and glioblastoma derived from Black Diamond’s MAP discovery engine.
[Black Diamond Therapeutics, Inc.] |
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| June 20 – 23, 2022
Seville, Spain |
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| | Gilead Sciences, Inc. – Foster City, California, United States |
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| | McGill University – Montreal, Quebec, Canada |
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| | Medical Center Cologne – Cologne, Germany |
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| | The Ohio State University – Columbus, Ohio, United States |
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| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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