| Vol. 11.26 – 7 July, 2022 |
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| Vaping has been reported to cause acute epiglottitis, a life-threatening airway obstruction induced by the direct epithelial injury and subsequent inflammatory reaction. Researchers showed that they were able to recapitulate this phenomenon in vitro. [Disease Models & Mechanisms] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the therapeutic role of exosomes in bronchopulmonary dysplasia. [European Journal of Pediatrics] |
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| Investigators evaluated, for the first time, the anticancer of a synthetic biscoumarin on lung cancer cells and explored the related mechanism. [Chinese Journal of Physiology] |
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| Scientists demonstrated that TRIB2, not a “pseudokinase”, had the kinase activity to directly phosphorylate PKM2 at serine 37 in cancer cells. [Cell Death Discovery] |
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| Researchers demonstrated the underlying molecular mechanisms of MTHFD2 in regulating cell proliferation and identified a novel therapeutic strategy improving the treatment efficacies in lung adenocarcinoma. [Cell Death Discovery] |
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| Investigators identified 1468 pyroptosis-related lncRNAs in lung squamous cell carcinoma by performing Pearson correlation analysis between the pyroptosis-related genes and the lncRNAs from The Cancer Genome Atlas and Gene Expression Omnibus database. [Scientific Reports] |
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| Scientists probed the effect of EphrinA3 on the proliferation of lung adenocarcinoma (LUAD) cells, and a transwell assay was employed to examine its effect on migration and invasion. [Cancer Medicine] |
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| Researchers successfully applied RNA-seq technology to demonstrate apurinic-apyrimidinic endonuclease-1 (APEX1) regulation of alternative splicing. [BMC Medical Genomics] |
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| The authors include a summary of the last twenty years of literature reports published on the disrupted tight junctions (TJs) and epithelial barrier in various lung conditions and expression and regulation of specific TJ proteins against pathogenic stimuli. [Inflammation] |
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| Scientists review the most recent literature on dysregulated aging pathways in idiopathic pulmonary fibrosis and COPD and discuss how they may contribute to disease pathogenesis. [Current Opinion in Pulmonary Medicine] |
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| Calithera Biosciences, Inc. announced that it has enrolled the first patient in a Phase II clinical trial of sapanisertib in patients with NFE2L2-mutated squamous NSCLC. [Calithera Biosciences, Inc.] |
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| Albert Einstein College of Medicine – Bronx, New York, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| University of Maryland School of Medicine – Baltimore, Maryland, United States |
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| McGill University – Montreal, Quebec, Canada |
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| Pennsylvania State University – State College, Pennsylvania, United States |
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