Pulmonary Cell News Volume 11.26 | Jul 7 2022

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    2022-07-07 | PULCN 11.26


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.26 – 7 July, 2022
    TOP STORY

    Exposure to E-Cigarette Vapor Extract Induces Vocal Fold Epithelial Injury and Triggers Intense Mucosal Remodeling

    Vaping has been reported to cause acute epiglottitis, a life-threatening airway obstruction induced by the direct epithelial injury and subsequent inflammatory reaction. Researchers showed that they were able to recapitulate this phenomenon in vitro.
    [Disease Models & Mechanisms]

    Abstract
    ON1104SM-Small-Molecules-Wallchart-728x90
    PUBLICATIONSRanked by the impact factor of the journal

    CircRNA, lncRNA, and mRNA Profiles of Umbilical Cord Blood Exosomes From Preterm Newborns Showing Bronchopulmonary Dysplasia

    Scientists investigated the therapeutic role of exosomes in bronchopulmonary dysplasia.
    [European Journal of Pediatrics]

    Full Article

    A Synthetic Biscoumarin Suppresses Lung Cancer Cell Proliferation and Induces Cell Apoptosis by Increasing Expression of RIP1

    Investigators evaluated, for the first time, the anticancer of a synthetic biscoumarin on lung cancer cells and explored the related mechanism.
    [Chinese Journal of Physiology]

    Full Article

    Oncogenic TRIB2 Interacts With and Regulates PKM2 To Promote Aerobic Glycolysis and Lung Cancer Cell Procession

    Scientists demonstrated that TRIB2, not a “pseudokinase”, had the kinase activity to directly phosphorylate PKM2 at serine 37 in cancer cells.
    [Cell Death Discovery]

    Full Article

    Targeting Mitochondrial One-Carbon Enzyme MTHFD2 Together With Pemetrexed Confers Therapeutic Advantages in Lung Adenocarcinoma

    Researchers demonstrated the underlying molecular mechanisms of MTHFD2 in regulating cell proliferation and identified a novel therapeutic strategy improving the treatment efficacies in lung adenocarcinoma.
    [Cell Death Discovery]

    Full Article

    Identification of Pyroptosis-Related Long Non-Coding RNAs With Prognosis and Therapy in Lung Squamous Cell Carcinoma

    Investigators identified 1468 pyroptosis-related lncRNAs in lung squamous cell carcinoma by performing Pearson correlation analysis between the pyroptosis-related genes and the lncRNAs from The Cancer Genome Atlas and Gene Expression Omnibus database.
    [Scientific Reports]

    Full Article

    EphrinA3 Is a Key Regulator of Malignant Behaviors and a Potential Prognostic Factor in Lung Adenocarcinoma

    Scientists probed the effect of EphrinA3 on the proliferation of lung adenocarcinoma (LUAD) cells, and a transwell assay was employed to examine its effect on migration and invasion.
    [Cancer Medicine]

    Full Article

    APEX1 Regulates Alternative Splicing of Key Tumorigenesis Genes in Non-Small-Cell Lung Cancer

    Researchers successfully applied RNA-seq technology to demonstrate apurinic-apyrimidinic endonuclease-1 (APEX1) regulation of alternative splicing.
    [BMC Medical Genomics]

    Full Article
    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    REVIEWS

    Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury

    The authors include a summary of the last twenty years of literature reports published on the disrupted tight junctions (TJs) and epithelial barrier in various lung conditions and expression and regulation of specific TJ proteins against pathogenic stimuli.
    [Inflammation]

    Abstract

    Revealing the Pathogenic and Aging-Related Mechanisms of the Enigmatic Idiopathic Pulmonary Fibrosis (and Chronic Obstructive Pulmonary Disease)

    Scientists review the most recent literature on dysregulated aging pathways in idiopathic pulmonary fibrosis and COPD and discuss how they may contribute to disease pathogenesis.
    [Current Opinion in Pulmonary Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    Calithera Biosciences Announces First Patient Enrolled in Phase II Clinical Trial of Sapanisertib in Relapsed/Refractory NRF2 (NFE2L2)-Mutated Squamous Non-Small Cell Lung Cancer

    Calithera Biosciences, Inc. announced that it has enrolled the first patient in a Phase II clinical trial of sapanisertib in patients with NFE2L2-mutated squamous NSCLC.
    [Calithera Biosciences, Inc.]

    Press Release
    FEATURED EVENT

    3D Cell Culture Symposium

    December 1, 2022
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Position – Cancer Research

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Fellow – Thoracic Malignancies

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow Positions – Translational Research

    University of Maryland School of Medicine – Baltimore, Maryland, United States

    Associate Professor – Division of Thoracic Surgery

    McGill University – Montreal, Quebec, Canada

    Research Technologist – Pediatrics

    Pennsylvania State University – State College, Pennsylvania, United States

    > See All Jobs

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