Pulmonary Cell News Volume 11.27 | Jul 14 2022

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    2022-07-14 | PULCN 11.27


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.27 – 14 July, 2022
    TOP STORY

    FoxA1 and FoxA2 Control Growth and Cellular Identity in NKX2-1-Positive Lung Adenocarcinoma

    Researchers found that Foxa1/2 knockout severely impaired tumorigenesis in KRAS-driven genetically engineered mouse models and human cell lines.
    [Developmental Cell]

    AbstractGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Mitochondrial PKM2 Deacetylation by Procyanidin B2-Induced SIRT3 Upregulation Alleviates Lung Ischemia/Reperfusion Injury

    Using sirtuin 3 (Sirt3)-knockout mice and specific SIRT3 knockdown in vitro, scientists found that SIRT3 strongly protected against lung ischemia/reperfusion injury.
    [Cell Death & Disease]

    Full Article

    Histone Deacetylase 3 Promotes Alveolar Epithelial–Mesenchymal Transition and Fibroblast Migration Under Hypoxic Conditions

    Investigators showed that histone deacetylase (HDAC) 3 regulated alveolar epithelial–mesenchymal transition markers via the AKT pathway during hypoxia and that inhibition of HDAC3 expression by small interfering RNA decreased the migration ability and invasiveness of diseased human lung fibroblasts.
    [Experimental & Molecular Medicine]

    Full Article

    Human Breast Milk-Derived Exosomes Through Inhibiting at II Cell Apoptosis To Prevent Bronchopulmonary Dysplasia in Rat Lung

    Scientists investigated the role and mechanism of human breast milk-derived exosomes in neonatal bronchopulmonary dysplasia.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    miRNA-6515-5p Regulates Particulate Matter-Induced Inflammatory Responses by Targeting CSF3 in Human Bronchial Epithelial Cells

    The authors investigated the role of miR-6515-5p in particulate matter10-induced inflammation in human bronchial epithelial BEAS-2B cells.
    [Toxicology in Vitro]

    Abstract

    Anti-Histamine Effects of Dipotassium Glycyrrhizinate on Lung Fibroblasts, Implicating Its Therapeutic Mechanism for Pulmonary Fibrosis

    To investigate the potential and underlying mechanisms for pulmonary fibrosis treatment, rat primary lung fibroblasts were extracted to establish cell models.
    [Journal of Pharmacy and Pharmacology]

    Abstract

    LKB1 Phosphorylation and Deactivation in Lung Cancer by NNAL, a Metabolite of Tobacco-Specific Carcinogen, in an Isomer-Dependent Manner

    Investigators reported that NNAL, a major metabolite of a tobacco-specific carcinogen NNK, induced LKB1 phosphorylation and its loss of function via the β-AR/PKA signaling pathway in an isomer-dependent manner in human lung cancer cells.
    [Oncogene]

    Full Article

    Capsaicin Induces Ferroptosis of NSCLC by Regulating SLC7A11/GPX4 Signaling In Vitro

    Researchers evaluated the roles of capsaicin in NSCLC cells and further explored its underlying mechanisms. Effect of capsaicin treatment on cell viability was determined by MTT assay and IC50 values for A549 and NCI-H23 cells were ascertained.
    [Scientific Reports]

    Full Article

    Farrerol Exhibits Inhibitory Effects on Lung Adenocarcinoma Cells by Activating the Mitochondrial Apoptotic Pathway

    Scientists investigated the biological effects of farrerol on lung adenocarcinoma cells.
    [Journal of Biochemical and Molecular Toxicology]

    Abstract

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    REVIEWS

    Deciphering the Role of Damage-Associated Molecular Patterns and Inflammatory Responses in Acute Lung Injury

    The authors address the mechanisms of damage-associated molecular patterns and their interactions in acute lung injury.
    [Life Sciences]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Pliant Therapeutics Announces Positive Safety and Efficacy Data from Phase IIa INTEGRIS-IPF Clinical Trial of PLN-74809 in Patients with Idiopathic Pulmonary Fibrosis

    Pliant Therapeutics, Inc. announced positive data from INTEGRIS-IPF, a multinational, randomized, double-blind, placebo-controlled Phase IIa clinical trial of PLN-74809 in patients with idiopathic pulmonary fibrosis.
    [Pliant Therapeutics, Inc.]

    Press Release

    COSELA® (Trilaciclib Hydrochloride for Injection) Now Approved in China to Decrease the Incidence of Chemotherapy-Induced Myelosuppression in Patients with Extensive-Stage Small Cell Lung Cancer (ES-SCLC)

    G1 Therapeutics, Inc. announced that the China National Medical Products Administration has conditionally approved COSELA, which was jointly developed for use in Greater China by Simcere and G1 Therapeutics.
    [G1 Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    16th International Symposium on Dendritic Cells 2022

    October 9 – 13, 2022
    Cairns, Australia

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Brain Metastasis from Lung and Breast Cancers

    Hershey College of Medicine – Hershey, Pennsylvania, United States

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Postdoctoral Position – Cancer Research

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Fellow – Thoracic Malignancies

    Baylor College of Medicine – Houston, Texas, United States

    Associate Professor – Division of Thoracic Surgery

    McGill University – Montreal, Quebec, Canada

    > See All Jobs

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