Pulmonary Cell News Volume 11.33 | Aug 25 2022

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    Danielle Corrigan
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    2022-08-25 | PULCN 11.33


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.33 – 25 August, 2022
    TOP STORY

    Regulation of Neuroendocrine Plasticity by the RNA-Binding Protein ZFP36L1

    To identify genes required for LSD1 inhibitor sensitivity in SCLC, the author performed a positive selection genome-wide CRISPR/Cas9 loss of function screen and found that ZFP36L1, an mRNA-binding protein that destabilized mRNAs, was required for LSD1 inhibitor sensitivity
    [Nature Communications]

    Full Article

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    Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents

    Researchers described the cellular complexity of human alveolar and tracheobronchial air liquid interface tissue models during SARS-CoV-2 and influenza A virus infections.
    [Communications Biology]

    Full Article

    Airway Epithelial Immunoproteasome Subunit LMP7 Protects against Rhinovirus Infection

    Scientists determined whether airway epithelial low-molecular mass protein 7 (LMP7) promoted the resolution of rhinovirus-mediated lung inflammation.
    [Scientific Reports]

    Full Article

    P21-Activated Kinase 2-Mediated β-Catenin Signaling Promotes Cancer Stemness and Osimertinib Resistance in EGFR-Mutant Non-Small-Cell Lung Cancer

    Investigators observed that the suppression of p21-activated kinase 2 (PAK2) via knockdown or pharmacological targeting with PAK inhibitors markedly restored the response of osimertinib-resistant NSCLC cells to osimertinib both in vitro and in vivo.
    [Oncogene]

    Abstract

    IGF-Binding Proteins Secreted by Cancer-Associated Fibroblasts Induce Context-Dependent Drug Sensitization of Lung Cancer Cells

    Researchers found that coculture with cancer-associated fibroblasts (CAFs) or culture in CAF-conditioned medium unexpectedly induced drug sensitivity in certain lung cancer cell lines.
    [Science Signaling]

    Full Article

    Crizotinib Attenuates Cancer Metastasis by Inhibiting TGFβ Signaling in Non-Small Cell Lung Cancer Cells

    Scientists found that crizotinib suppressed TGFβ signaling by blocking Smad phosphorylation in an ALK/MET/RON/ROS1-independent manner in NSCLC cells.
    [Experimental & Molecular Medicine]

    Full Article

    DNA Methylome and Single-Cell Transcriptome Analyses Reveal CDA as a Potential Druggable Target for ALK Inhibitor–Resistant Lung Cancer Therapy

    Investigators used an in vitro model of ceritinib-resistant NSCLC and employed genome-wide DNA methylation analysis in combination with single-cell RNA-seq to identify cytidine deaminase, a pyrimidine salvage pathway enzyme, as a candidate drug target.
    [Experimental & Molecular Medicine]

    Full Article

    Neferine, a Novel ROCK1-Targeting Inhibitor, Blocks EMT Process and Induces Apoptosis in Non-Small Cell Lung Cancer

    The effects and mechanisms of Neferine on the epithelial-to-mesenchymal (EMT) transition process in NSCLC were evaluated.
    [Journal of Cancer Research and Clinical Oncology]

    Abstract

    Multi-Hallmark Long Noncoding RNA Maps Reveal Non-Small Cell Lung Cancer Vulnerabilities

    The authors employed pooled CRISPR deletion to perturb 831 long noncoding RNAs detected in KRAS-mutant NSCLC and measured their contribution to proliferation, chemoresistance, and migration across two cell backgrounds.
    [Cell Genomics]

    Full ArticleGraphical Abstract

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    REVIEWS

    The DiscovAIR Project: A Roadmap towards the Human Lung Cell Atlas

    DiscovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung.
    [European Respiratory Journal]

    Full Article

    INDUSTRY AND POLICY NEWS

    FDA Granted Orphan Drug Designation to IMP4297+TMZ for SCLC

    IMPACT Therapeutics announced that the US FDA has granted Orphan Drug Designation to their fixed-dose combination capsule of Senaparib and temozolomide (TMZ) for the treatment of adult patients with SCLC.
    [IMPACT Therapeutics (Globenewswire, Inc.)]

    Press Release

    FEATURED EVENT

    Novel Approaches Against Emerging Antimicrobial Resistance

    December 4 – 7, 2022
    Banff, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Associate Professor – Solid Cancer Tumor Development

    Michigan State University – East Lansing, Michigan, United States

    Postdoctoral Researcher – Lung Cancer and Lymphoma

    University of Cologne – Cologne, Germany

    Postdoctoral Researcher – Cancer and Stem Cell Biology

    Stanford Medicine – Stanford, California, United States

    Postdoctoral Position – Lung Cancer

    NYU Langone Health – New York, New York, United States

    Senior Investigator – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    > See All Jobs

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