DNA Methylome and Single-Cell Transcriptome Analyses Reveal CDA as a Potential Druggable Target for ALK Inhibitor–Resistant Lung Cancer Therapy

Investigators used an in vitro model of ceritinib-resistant NSCLC and employed genome-wide DNA methylation analysis in combination with single-cell RNA-seq to identify cytidine deaminase, a pyrimidine salvage pathway enzyme, as a candidate drug target.