Pulmonary Cell News Volume 11.35 | Sep 8 2022

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    2022-09-08 | PULCN 11.35


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.35 – 8 September, 2022
    TOP STORY

    Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity

    Investigators determined if CC16 mRNA expression levels in non-ciliated bronchial epithelial cells were associated with asthma severity.
    [American Journal of Respiratory and Critical Care Medicine]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Tobacco Carcinogen Induces Tryptophan Metabolism and Immune Suppression via Induction of Indoleamine 2,3-Dioxygenase 1

    Researchers found that tobacco smoke, a major public health concern that kills 8 million people each year worldwide, induced IDO1 in normal and malignant lung epithelial cells in vitro and in vivo.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Long Read Genome Assemblies Complemented by Single Cell RNA-Sequencing Reveal Genetic and Cellular Mechanisms Underlying the Adaptive Evolution of Yak

    The authors assembled two chromosome-level genomes, one each for wild yak and domestic yak, and screened structural variants through the long-read data of yak and taurine cattle.
    [Nature Communications]

    Full Article

    Early Transcriptional Responses of Bronchial Epithelial Cells to Whole Cigarette Smoke Mirror Those of In Vivo Exposed Human Bronchial Mucosa

    Scientists investigated early transcriptomic responses following cigarette smoke (CS) exposure of airway epithelial cells in culture and compared these to those found in human CS exposure studies.
    [Respiratory Research]

    Full Article

    LncRNA HOTAIRM1 Involved in Nano NiO-Induced Pulmonary Fibrosis via Regulating PRKCB DNA Methylation-Mediated JNK/C-Jun Pathway

    Investigators aimed to clarify the regulatory relationship among long noncoding RNA HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1), DNA methylation and expression of protein kinase C beta (PRKCB), and JNK/c-Jun pathway in Nano NiO-induced pulmonary fibrosis.
    [Toxicological Sciences]

    Abstract

    MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer

    Scientists discovered that MET amplification, the most common mechanism of resistance to third generation EGFR tyrosine kinase inhibitors, activated tumor cell STING, an emerging determinant of cancer immunogenicity.
    [Cancer Research]

    Abstract

    LINC00152 Induced by TGF-β Promotes Metastasis via HuR in Lung Adenocarcinoma

    Researchers screened lncRNAs responsive to TGF-β and highly expressed in lung adenocarcinoma cells, and obtained their master molecular LINC00152.
    [Cell Death & Disease]

    Full Article
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    REVIEWS

    3D Tissue-Engineered Lung Models to Study Immune Responses Following Viral Infections of the Small Airways

    The authors outline the use of various cell types, scaffolds, and culture conditions for creating 3D human tissue-engineered lung models.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Transformative $78M Gift to Establish New Precision Oncology Institute

    A transformational commitment by Stuart Sloan and his wife Molly Sloan of $78M to establish the Stuart and Molly Sloan Precision Oncology Institute at Fred Hutchinson Cancer Center aimed to help researchers fulfill the early promise of this data-driven approach.
    [Fred Hutchinson Cancer Center]

    Press Release
    FEATURED EVENT

    Type 2 Immunity in Homeostasis and Disease (2nd Edition)

    December 12 – 13, 2022
    Ghent, Belgium

    > See All Events

    JOB OPPORTUNITIES

    Assistant/Associate Professor – Comparative Biomedical Science

    Louisiana State University – Baton Rouge, Louisiana, United States

    Postdoctoral Research Associate – Lung Cancer Dissemination and Metastasis

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Fellows – Immunology/Bioinformatics

    Boston University – Boston, Massachusetts, United States

    PhD candidate – Research Project Ferroptose

    Helmholtz Munich – Neuherberg, Germany

    Postdoctoral Scientist Positions – Preclinical Pharmacology

    CRUK Manchester Institute – Manchester, England, United Kingdom

    > See All Jobs

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