 | | Vol. 11.37 – 22 September, 2022 |
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| Scientists identified that Neisseria spp. within the bronchiectasis bacteriome was associated with poorer clinical outcomes, promoting the loss of epithelial integrity and inflammation in primary epithelial cells.
[Cell Host & Microbe] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that pyruvate kinase M2 (PKM2) promoted pulmonary fibrosis progression by directly interacting with Smad7 and reinforcing transforming growth factor–β1 (TGF-β1) signaling.
[Science Advances] |
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| Scientists discovered that pulmonary neuroendocrine cells sensed succinate, which then caused short-range ATP signals to contract the myoepithelial cells wrapped around airway submucosal glands.
[Developmental Cell] |
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| Investigators explored the role of miR-378 in alveolar epithelial type II cells and identified molecular mechanisms which contributed to the pathogenesis of COPD.
[Peerj] |
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| To investigate the underlying mechanism of ubiquitin-specific protease 22 (USP22) expression in NSCLC, researchers utilized luciferase reporters to identify potential transcription factor upregulating USP22 expression in human NSCLC cells.
[Cell Communication and Signaling] |
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| Scientists investigated three toxic compounds emitted from cooking oil fumes as human carcinogenic or mutagenic compounds to systematically evaluate the damage to cancer and healthy cells with low dose exposure.
[Scientific Reports] |
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| Investigators summarize the underlying mechanisms of tyrosine kinase inhibitors (TKIs) resistance and discuss the potential approaches to overcome it, aiming to provide a theoretical basis for improving the efficacy of TKIs for various cancer treatments, including NSCLC.
[Signal Transduction and Targeted Therapy] |
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| Over $20 million was awarded for 78 research projects being led by researchers at the University of British Columbia, including Dr. Tillie-Louise Hackett, who is studying spatial single cell Imaging in the lung.
[UBC Faculty of Medicine] |
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| November 6 – 8, 2022
Seville, Spain |
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| | BC Cancer Research Institute – Vancouver, British Columbia, Canada |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | Stanford University – Palo Alto, California, United States |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, United Kingdom |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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