Pulmonary Cell News Volume 11.38 | Sep 29 2022

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    Jamie Kang
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    2022-09-29 | PULCN 11.38


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.38 – 29 September, 2022
    TOP STORY

    Airway Basal Cells Show a Dedifferentiated KRT17high Phenotype and Promote Fibrosis in Idiopathic Pulmonary Fibrosis

    Researchers determined transcriptional changes of idiopathic pulmonary fibrosis-airway basal cells and their potential profibrotic properties using a 3D culture system and novel mouse xenograft models.
    [Nature Communications]

    Full Article

    Learn about optimization of in vitro lung models in this webinar by Dr. Rachael Rayner
    PUBLICATIONSRanked by the impact factor of the journal

    Liposomal UHRF1 siRNA Shows Lung Fibrosis Treatment Potential by Regulating Fibroblast Activation

    Investigators found that growth factor–β1-mediated upregulation of UHRF1 repressed Beclin1 via promoter methylation induction which resulted in fibroblast activation and lung fibrosis both in vitro and in vivo.
    [JCI Insight]

    AbstractGraphical Abstract

    Lung Fibrosis Finds an Unsung Hero in Neuropeptide Y

    Scientists studied neuropeptide Y, a small peptide normally synthesized in the central and peripheral nervous system and implicated in inflammatory airway diseases including asthma and COPD.
    [American Journal of Respiratory Cell and Molecular Biology]

    Abstract

    miR-31/QKI-5 Axis Facilitates Cell Cycle Progression of Non-Small-Cell Lung Cancer Cells by Interacting and Regulating p21 and CDK4/6 Expressions

    Investigators demonstrated that RNA-binding protein Quaking-5 suppressed NSCLC cell proliferation both in vitro and in vivo by inhibiting cell cycle progression by regulating cell cycle G1 phase-related proteins.
    [Cancer Medicine]

    Full Article

    Inhibiting ALK-TOPK Signaling Pathway Promotes Cell Apoptosis of ALK-Positive NSCLC

    Researchers discovered that T-LAK cell-oriented protein kinase (TOPK) was highly expressed in anaplastic lymphoma kinase (ALK)-positive NSCLC. Phosphorylation of TOPK by ALK was found to inhibit enhanced apoptosis of ALK-positive NSCLC cells, providing novel treatment strategies.
    [Cell Death & Disease]

    Full Article

    DDX17 Modulates the Expression and Alternative Splicing of Genes Involved in Apoptosis and Proliferation in Lung Adenocarcinoma Cells

    Scientists explored the functions of DDX17 as an oncogene by regulating both the expression and alternative splicing of proliferation- and apoptosis-associated genes in lung adenocarcinoma cells.
    [Peerj Life & Environment]

    Full Article

    Circular RNA hsa_circ_0018189 Drives Non-Small Cell Lung Cancer Growth by Sequestering miR-656-3p and Enhancing xCT Expression

    While identifying the relationship and functions of CircRNAs in NSCLC, researchers discovered that Hsa_circ_0018189 drove NSCLC growth by interacting with miR-656-3p and upregulating xCT.
    [Journal of Clinical Laboratory Analysis]

    Full Article
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    REVIEWS

    CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance

    The authors review the roles of CXC ligands and their cognate receptors in the pathogenesis of several lung diseases such as allergic rhinitis, COPD, lung fibrosis, lung cancer, pneumonia, and tuberculosis.
    [International Journal of Inflammation]

    Full Article
    INDUSTRY AND POLICY NEWS

    Bellerophon Announces FDA Acceptance of Change to Ongoing Phase III REBUILD Study of INOpulse® for Treatment of Fibrotic Interstitial Lung Disease

    Bellerophon Therapeutics, Inc. announced that the FDA has accepted the company’s proposal to reduce the study size for its ongoing registrational REBUILD Phase III trial of INOpulse® for the treatment of fibrotic interstitial lung disease.
    [Bellerophon Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Organoids as Models of Development and Disease, and Their Impact on Drug Discovery

    February 5 – 8, 2023
    Keystone, Colorado, United States

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Psychoneuroimmunology of Respiratory Disorders

    University of Alberta – Edmonton, Alberta, Canada

    Clinical Research Fellowship – Lung Cancer

    BC Cancer Agency – Victoria, British Columbia, Canada

    Postdoctoral Fellow – Asbestos and Lung Cancer

    The University of British Columbia – Vancouver, British Columbia, Canada

    Faculty Position – Lung Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Research Professional – Pulmonary Vascular Development

    Stanford University – Palo Alto, California, United States

    > See All Jobs

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