Pulmonary Cell News Volume 11.39 | Oct 06 2022

    By
    Jamie Kang
    -
    0
    22








    2022-10-06 | PULCN 11.39


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.39 – 6 October, 2022
    TOP STORY

    Stratifin as a Novel Diagnostic Biomarker in Serum for Diffuse Alveolar Damage

    In vitro analysis using cultured lung epithelial cells revealed extracellular release of stratifin/14-3-3σ occurred via p53-dependent apoptosis.
    [Nature Communications]

    Full Article
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal

    Insight into the Pulmonary Molecular Toxicity of Heated Tobacco Products Using Human Bronchial and Alveolar Mucosa Models at Air–Liquid Interface

    Researchers assessed the toxicological response of heated tobacco products-smoke using the International Organization for Standardization puffing regimen in an established physiologically relevant bronchial and alveolar lung mucosa models developed at air–liquid interface.
    [Scientific Reports]

    Full Article

    Effects of Systemic Anticoagulation in a Murine Model of Compensatory Lung Growth

    The authors explored the effects of unfractionated heparin, low molecular weight heparin, and bivalirudin on a murine model of compensatory lung growth by assessing the proliferation and apoptosis of microvascular lung endothelial cells.
    [Pediatric Research]

    Abstract

    iPSC-Derived Mesenchymal Cells That Support Alveolar Organoid Development

    Investigators generated induced pluripotent stem cell (iPSC)-derived mesenchymal cells that had the ability to develop alveolar organoids with the aim of modeling niche environments and diseases.
    [Cell Reports Methods]

    Full ArticleGraphical Abstract

    Transient Targeting of BIM-Dependent Adaptive MCL1 Preservation Enhances Tumor Response to Molecular Therapeutics in Non-Small Cell Lung Cancer

    By interrogating therapy-induced protein changes in diverse oncogene-addicted non-small cell lung cancer models, scientists identified adaptive MCL1 as a new and universal mechanism to confer apoptotic evasion and drug-tolerant persister formation.
    [Cell Death & Differentiation]

    Abstract

    Deubiquitylase OTUD1 Confers Erlotinib Sensitivity in Non-Small Cell Lung Cancer through Inhibition of Nuclear Translocation of YAP1

    Investigators studied the anti-tumor effect and clarified the downstream mechanisms of OTUD1 in the chemoresistance of NSCLC cells.
    [Cell Death Discovery]

    Full Article

    BMP2 Promotes Lung Adenocarcinoma Metastasis through BMP Receptor 2-Mediated SMAD1/5 Activation

    Scientists revealed that bone morphogenetic protein 2 (BMP2) was highly overexpressed in lung adenocarcinoma patients with lymph node metastasis and may be promoting metastatic NSCLC.
    [Scientific Reports]

    Full Article

    Afatinib Triggers a Ni2+-Resistant Ca2+ Influx Pathway in A549 Non-Small Cell Lung Cancer Cells

    Investigators examined if afatinib had cytotoxic action against NSCLC other than inhibition of tyrosine kinase and discovered that afatinib caused apoptotic death in a concentration-dependent manner.
    [Fundamental & Clinical Pharmacology]

    Abstract
    Learn how to stay motivated in research.
    REVIEWS

    iPSC-Derived Airway Epithelial Cells: Progress, Promise, and Challenges

    The authors provided a comprehensive overview of recent progress toward the use of induced pluripotent stem cells (iPSCs) to generate proximal and distal airway epithelial cells and mix lung organoids.
    [Stem Cells]

    Abstract
    Graphical Abstract
    INDUSTRY AND POLICY NEWS

    Eagle Pharmaceuticals and Enalare Therapeutics Announce FDA Orphan Drug Designation for ENA-001 for the Treatment of Apnea of Prematurity, a New Chemical Entity Being Developed as an Agnostic Respiratory Stimulant

    Eagle Pharmaceuticals, Inc. announced that the FDA had granted Orphan Drug Designation to ENA-001 for the treatment of Apnea of Prematurity, a new chemical entity with a novel mechanism of action as a respiratory stimulant.
    [Eagle Pharmaceuticals, Inc.]

    Press Release

    Beyond Air® Announces That Annals of the American Thoracic Society Published a Review of the Third Pilot Study of High Dose Nitric Oxide for Bronchiolitis

    Beyond Air, Inc. announced that the Annals of the American Thoracic Society published a detailed review of the company’s third pilot study of inhaled nitric oxide in bronchiolitis patients.
    [Beyond Air, Inc.]

    Press Release
    FEATURED EVENT

    Skin Ageing & Challenges 2022

    November 17 – 18, 2022
    Lisbon, Portugal

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Lung Cancer

    University of Minnesota – Austin, Minnesota, United States

    Postdoctoral – Cardiovascular Disease and Pulmonary Hypertension

    University of Alberta – Edmonton, Alberta, Canada

    Postdoctoral Fellow – Psychoneuroimmunology of Respiratory Disorders

    University of Alberta – Edmonton, Alberta, Canada

    Clinical Research Fellowship – Lung Cancer

    BC Cancer Agency – Victoria, British Columbia, Canada

    Postdoctoral Fellow – Asbestos and Lung Cancer

    The University of British Columbia – Vancouver, British Columbia, Canada

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Pulmonary Cell News Twitter