Pulmonary Cell News Volume 11.40 | Oct 13 2022

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    2022-10-13 | PULCN 11.40


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.40 – 13 October, 2022
    TOP STORY

    Consequences of Telomere Dysfunction in Fibroblasts, Club, and Basal Cells for Lung Fibrosis Development

    Investigators studied the lung pathologies upon telomere dysfunction in fibroblasts, club, and basal cells. Telomeric repeat-binding factor 1 deficiency induced telomeric damage, proliferative defects, cell cycle arrest, and apoptosis.
    [Nature Communications]

    Full ArticlePress Release
    How to prioritize and manage your research projects
    PUBLICATIONSRanked by the impact factor of the journal

    Airway Surface Hyperviscosity and Defective Mucociliary Transport by IL-17/TNF-α Are Corrected by Beta-Adrenergic Stimulus

    Researchers investigated the effects of IL-17A and TNF-α, two cytokines with a relevant role in cystic fibrosis and other chronic lung diseases.
    [JCI Insight]

    AbstractFull Article

    Pim-1 Kinase Is a Positive Feedback Regulator of the Senescent Lung Fibroblast Inflammatory Secretome

    Scientists assessed the role of Pim-1 kinase as a driver of NF-κB-induced production of inflammatory cytokines from low-passage idiopathic pulmonary fibrosis fibroblast cultures displaying markers of senescence.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    Pharmacological Inhibitors of the Cystic Fibrosis Transmembrane Conductance Regulator Exert Off-Target Effects on Epithelial Cation Channels

    Investigators presented that cystic fibrosis transmembrane conductance regulator (CFTR) blockers caused a significant inhibition of store-operated calcium entry that was time-dependent, poorly reversible, and independent of CFTR.
    [Pflugers Archiv-European Journal of Physiology]

    Full Article

    Polystyrene Microplastics Induce Autophagy and Apoptosis in Birds Lungs via PTEN/PI3K/AKT/mTOR

    Broilers treated with different polystyrene microplastics (PS-MPs) were exposed to drinking water for six weeks to analyze the effect and emchanism of PS-MPs on lung injury.
    [Environmental Toxicology]

    Abstract

    ZIP1+ Fibroblasts Protect Lung Cancer against Chemotherapy via Connexin-43 Mediated Intercellular Zn2+ Transfer

    Researchers discovered that zinc-transporter (ZIP1) positive tumour-associated fibroblast subset was enriched after chemotherapy and directly interconnects lung cancer cells with gap junctions.
    [Nature Communications]

    Full Article

    Long Non-coding RNA DLGAP1-AS1 Modulates the Development of Non-Small Cell Lung Cancer via the microRNA-193a-5p/DTL Axis

    Investigators reported a novel lncRNA DLG Associated Protein 1 antisense RNA 1(DLGAP1-AS1) that exhibited oncogenic properties in NSCLC.
    [Laboratory Investigation]

    Abstract

    MiR-485-5p Suppress the Malignant Characteristics of the Lung Adenocarcinoma via Targeting NADPH Quinone Oxidoreductase-1 to Inhibit the PI3K/Akt

    Scientists explored how NADPH quinone oxidoreductase-1 (NQO1) and miR-485-5p affected lung adenocarcinoma (LUAD) cells and found that targeting NQO1 and miR-485-5p could suppress LUAD cell migration and proliferation, and induce apoptosis.
    [Molecular Biotechnology]

    Abstract
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    REVIEWS

    Understanding the Role of Placental Pathophysiology in the Development of Bronchopulmonary Dysplasia (BPD)

    The authors review the role of the placenta in BPD predisposition as a primary driver of intrauterine alterations adversely impacting fetal lung development.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    Roles of Biomarkers in Anti-MDA5-Positive Dermatomyositis, Associated Interstitial Lung Disease, and Rapidly Progressive Interstitial Lung Disease

    Investigators summarize progress in emerging roles and potential clinical applications of blood biomarkers, including protein, antibody, gene, and circulating immune cells for interstitial lung diseases.
    [Journal of Clinical Laboratory Analysis]

    Full Article
    INDUSTRY AND POLICY NEWS

    United Therapeutics Announces First Patient Enrolled in Phase III TETON 2 Study of Tyvaso in Patients with Idiopathic Pulmonary Fibrosis

    United Therapeutics Corporation announced that the first patient has enrolled in the Phase III TETON2 study which will evaluate Tyvaso in 396 adult patients with idiopathic pulmonary fibrosis at sites outside the United States and Canada.
    [United Therapeutics Corporation]

    Press Release
    FEATURED EVENT

    Frontiers in Cancer Science 2022

    November 7 – 9, 2022
    Singapore, Singapore

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    JOB OPPORTUNITIES

    Postdoctoral Associate – Respiratory Infections

    University of Florida – Gainesville, Florida, United States

    Faculty Member – Respiratory Research

    Mayo Clinic – Rochester, Minnesota, United States

    Postdoctoral Associate – Lung Cancer

    University of Minnesota – Austin, Minnesota, United States

    Postdoctoral – Cardiovascular Disease and Pulmonary Hypertension

    University of Alberta – Edmonton, Alberta, Canada

    Postdoctoral Fellow – Psychoneuroimmunology of Respiratory Disorders

    University of Alberta – Edmonton, Alberta, Canada

    > See All Jobs

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