 | | Vol. 11.41 – 20 October, 2022 |
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| To develop a small molecule available to selectively target neddylation E2 UBE2F for the treatment of lung cancer, researchers utilized a structure-based virtual screen and chemical optimizations to discover HA-9104.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that NEDD4 Like E3 Ubiquitin Protein Ligase (Nedd4L) levels were significantly suppressed in lung myofibroblasts in idiopathic pulmonary fibrosis patients, experimental pulmonary fibrosis, and TGF-β1-treated lung fibroblasts.
[Translational Research] |
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| Researchers studied the effects of systemic lupus erythematosus (SLE) and COPA syndrome on diffuse alveolar hemorrhage and endoplasmic reticulum stress.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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| While trying to elucidate the biological functions and mechanism of circular RNA in acute respiratory distress syndrome, scientists found that circUBXN7 was significantly increased in lipopolysaccharide-induced A549 and Beas-2B cell injury.
[International Journal of Biochemistry & Cell Biology] |
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| Researchers demonstrated that conditioned medium from lung cancer-associated fibroblasts (CAFs) exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and CAFs.
[Cellular & Molecular Immunology] |
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| Investigators discovered LCAT1 physically interacted with and stabilized IGF2BP2, an m<sup>6</sup>A reader protein, by preventing its degradation via autolysosomes in lung cancer cells.
[Cell Death & Disease] |
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| Lung cancer was chosen to explore the NT157 multi-target effects as it was found associated with multiple activated oncogenic pathways relevant to the neoplastic phenotype targets of the drug.
[Scientific Reports] |
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| The authors review the roles and regulatory mechanisms of ncRNAs and discuss the effects on pulmonary epithelial and endothelial cell barriers.
[Pharmacological Research] |
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| Investigators examine the potential contributions of the alveolar epithelium to metastatic progression, as well as provides insight into other ways in which alveolar epithelial cells may influence metastatic progression.
[American Journal of Physiology-Cell Physiology] |
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| Biodesix, Inc. announced the award of a US Federal Supply Schedule contract which included the Veterans Health Administration providing care for US Veterans and the Military Health System providing care for active-duty service members and their families.
[Biodesix, Inc.] |
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| Aptar Digital Health, part of Aptar Pharma, announced a strategic partnership with the Chiesi Group, the international research-focused biopharmaceutical and healthcare group, to bring to market a disease management platform for asthma and COPD.
[Aptar Digital Health] |
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| November 14 – 17, 2022
Portland, Oregon, United States |
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| | University of Colorado – Aurora, Colorado, United States |
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| | NCI – Bethesda, Maryland, United States |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | Merck & Co., Inc. – North Wales, Pennsylvania, United States |
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| | University of Florida – Gainesville, Florida, United States |
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