 | | Vol. 11.43 – 3 November, 2022 |
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| Researchers investigated the mechanistic contribution of the coxsackievirus adenovirus receptor in mediating responses to the common aeroallergen, house dust mite.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Basal cells were isolated from idiopathic pulmonary fibrosis (IPF) explant and healthy donor lung tissues to study their role in IPF. 3D organoid culture assays were then used to interrogate basal cell effects on AEC2 renewal capacity.
[American Journal of Respiratory Cell and Molecular Biology] |
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| Scientists provided evidence that E-cadherin played a causal role in the pathogenesis of emphysema and airway dysfunction in patients with COPD.
[Communications Biology] |
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| Investigators studied the mechanism of bronchiectasis in autosomal dominant polycystic kidney disease caused by PKD1 deficiency and discovered that PKD1 in airway epithelial may be a potential target for the development of new strategies for the diagnosis and treatment of bronchiectasis.
[Respiratory Research] |
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| An anti-Bcl-xL siRNA was formulated within an EGFR-targeted nanomedicine with scFv ligands and its activity was tested in the NSCLC cell line H460.
[International Journal of Pharmaceutics] |
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| After screening a series of curcumin derivatives synthesized in the laboratory, scientists found that CUR5g selectively inhibited autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion.
[Cell Death Discovery] |
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| Researchers examined the role of neuro-oncological ventral antigen 1 (NOVA1) in NSCLC and its underlying molecular mechanisms.
[BMC Cancer] |
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| Investigators scrutinize different reports related to the harmful effects of SARS-CoV-2 on patients with asthma and COPD, as well as the possible therapeutic effects of stem cells in the alleviation of post-COVID-19 complications.
[Cell Communication and Signaling] |
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| The authors review the relationship between extracellular vesicles and the various alveolar cells involved in mediating acute lung injury/acute respiratory distress syndrome (ALI/ARDS), with a focus on their roles in pathogenesis and therapeutic strategies for ALI/ARDS.
[Military Medical Research] |
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| TFF Pharmaceuticals, Inc. announced that a second patient has been successfully treated with TFF Pharmaceuticals’ proprietary Voriconazole Inhalation Powder through a compassionate use program.
[TFF Phamaceuticals, Inc.] |
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| Boehringer Ingelheim announced that the first patient has enrolled in FIBRONEERTM-IPF, a global Phase III trial evaluating BI 1015550, an investigational phosphodiesterase 4B inhibitor, in people living with idiopathic pulmonary fibrosis (IPF).
[Boehringer Ingelheim] |
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| December 7 – 9, 2022
Geneva, Switzerland |
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| | University of Florida – Gainesville, Florida, United States |
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| | Monash University – Melbourne, Australia |
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| | University of Nottingham – Nottingham, England, United Kingdom |
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| | Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | University of Antwerp – Antwerp, Belgium |
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