 | | Vol. 11.46 – 24 November, 2022 |
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| Researchers demonstrated that alveolar cell fate specification was dictated by a classic growth factor signal, the same FGF signaling pathway that controlled the earlier steps of airway budding and branching and also initiated subsequent budding.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists presented that platelet endothelial aggregation receptor 1 (PEAR1) in fibroblasts may serve as a target for pulmonary fibrosis therapy.
[Nature Communications] |
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| The authors combined the generation of well-controlled and chemically defined synthetic reference aerosols with state-of-the-art cell cultures, particle exposure, and analysis to identify specific aerosol properties adversely affecting respiratory health.
[Environmental Science & Technology] |
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| Investigators demonstrated that Emodin attenuated pulmonary fibrosis induced by bleomycin in mice, and inhibited epithelial-mesenchymal transition, meanwhile downregulated c-MYC, upregulated miR-182-5p, and downregulated ZEB2 in vitro and in vivo.
[Phytotherapy Research] |
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| Scientists investigated the mechanisms of effective-component compatibility of Bufei Yishen formula III in chronic obstructive pulmonary disease rats from the aspect of airway epithelial cell senescence.
[BMC Pulmonary Medicine] |
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| The authors identified hypermitophagy as a feature of human lung cancer stem-like cells (CSCs), promoting metabolic adaption via the Notch1-AMPK axis to drive CSC expansion.
[EMBO Reports] |
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| Researchers investigated whether growth factors produced by the microenvironment affected the sensitivity of NTRK1-rearranged colon cancer KM12SM cells and ROS1-rearranged NSCLC HCC78 cells to entrectinib both in vitro and in vivo.
[Cancer Medicine] |
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| Scientists found that anwuligan inhibited the growth and metastasis of NSCLC cells in vivo and in vitro by upregulating the expression of let-7c-3p, which could regulate the PI3K/AKT/mTOR signaling pathway.
[Cancer Medicine] |
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| Investigators explored a rational combination strategy for enhancing the osimertinib efficacy and found that it induced higher CD47 expression, an important anti-phagocytic immune checkpoint, via the NF-κB pathway.
[Frontiers of Medicine] |
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| The authors summarize and highlight recent findings that establish the role of chemokines in SCLC growth and metastasis, and sophisticated intratumor heterogeneity.
[Seminars in Cancer Biology] |
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| Investigators elucidate the mechanism of bronchopulmonary dysplasia (BPD), focusing on the multiple types of programmed cell death in BPD and their molecular mechanisms, which are mainly based on experimental results obtained in rodents.
[Apoptosis] |
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| Astrotech Corporation subsidiary, BreathTech Corporation, announced that, based on analysis of data from testing of breath samples procured during our library development, the BreathTest-1000TM lung disease screening instrument can clearly distinguish between infected and healthy breath samples.
[Astrotech Corporation] |
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| December 1 – 3, 2022
Madrid, Spain |
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| | Cedars Sinai Medical Centre – Los Angeles, California, United States |
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| | Charite – University Medicine Berlin – Berlin, Germany |
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| | Baylor College of Medicine – Austin, Texas, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | Yale University – New Haven, Connecticut, United States |
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