Pulmonary Cell News Volume 11.48 | Dec 08 2022

December 8, 2022

2022-12-08 | PULCN 11.48

Pulmonary Cell News by STEMCELL Technologies

Vol. 11.48 – 8 December, 2022

TOP STORY

The Influenza-Injured Lung Microenvironment Promotes MRSA Virulence, Contributing to Severe Secondary Bacterial Pneumonia

By conditioning Staphylococcus aureus (MRSA) ex vivo in bronchoalveolar lavage fluid collected from influenza infected mice, investigators found that the influenza-injured lung microenvironment dynamically induced MRSA to increase cytotoxin expression, while decreasing metabolic pathways.
[Cell Reports]

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ASK1-ER Stress Pathway-Mediated Fibrotic-EV Release Contributes to the Interaction of Alveolar Epithelial Cells and Lung Fibroblasts to Promote Mechanical Ventilation-Induced Pulmonary Fibrosis

Researchers demonstrated that apoptosis signal-regulating kinase 1 (ASK1)-endoplasmic reticulum stress pathway-mediated fibrotic-extracellular vesicle released from alveolar epithelial cells contributed to fibroblast activation and the initiation of pulmonary fibrosis during mechanical ventilation.
[Experimental & Molecular Medicine]

Full Article

Discovery of a Pyrano[2,3-b]pyridine Derivative YX-2102 as a Cannabinoid Receptor 2 Agonist for Alleviating Lung Fibrosis

Scientists discovered a novel cannabinoid 2 receptor agonist from an in-house library, and evaluated its therapeutic effects on the pulmonary fibrosis model, as well as the mechanism.
[Journal of Translational Medicine]

Full Article

H3K27 Tri-Demethylase JMJD3 Inhibits Macrophage Apoptosis by Promoting ADORA2A in Lipopolysaccharide-Induced Acute Lung Injury

An acute lung injury murine model with intratracheal administration of lipopolysaccharide (LPS) and RAW264.7 cells with LPS stimulation were used in in vivo and in vitro experiments.
[Cell Death Discovery]

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Desloratadine, an FDA-Approved Cationic Amphiphilic Drug, Inhibits SARS-CoV-2 Infection in Cell Culture and Primary Human Nasal Epithelial Cells by Blocking Viral Entry

Investigators assessed the anti-SARS-CoV-2 effectiveness of eight FDA-approved cationic amphiphilic drugs on human nasal epithelial cells and revealed their antiviral mode of action.
[Scientific Reports]

Full Article

HIF1-α Upregulation Induces Proinflammatory Factors to Boost Host Killing Capacity after Aspergillus fumigatus Exposure

Scientists demonstrated the effect of upregulation of HIF1-α expression in A549 cells and mouse airway cells exposed to A. fumigatus in vivo.
[Future Microbiology]

Full Article

Pseudomonas aeruginosa Promotes Persistence of Stenotrophomonas maltophilia via Increased Adherence to Depolarized Respiratory Epithelium

Investigators used host and bacterial RNA sequencing to further understand the molecular underpinnings of the interaction between Pseudomonas aeruginosa promoting colonization and persistence of S. maltophilia in mouse respiratory infections and cystic fibrosis respiratory epithelial cells.
[Microbiology Spectrum]

Full Article

LUNG CANCER

Honokiol Inhibits Interleukin-Induced Angiogenesis in the NSCLC Microenvironment through the NF-κB Signaling Pathway

Scientists investigated how lignin analogs, specifically honokiol, blocked angiogenesis induced by the inflammatory milieu of lung cancer.
[Chemico-Biological interactions]

Full Article

ANGPTL4 Regulates Lung Adenocarcinoma Pyroptosis and Apoptosis via NLRP3\ASC\Caspase 8 Signaling Pathway to Promote Resistance to Gefitinib

By examining the characteristics of gefitinib-resistant PC9/GR cells in NSCLC, researchers investigated the function and mechanism of ANGPTL4 in the process of acquiring drug resistance in lung adenocarcinoma.
[Journal of Oncology]

Full Article

REVIEWS

Human Lung Organoid: Models for Respiratory Biology and Diseases

The authors summarize the current novel lung organoid culture strategies and discuss their application for understanding the lung biological features and pathophysiology of pulmonary diseases, especially COVID-19.
[Developmental Biology]

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INDUSTRY AND POLICY NEWS

First Wave Biopharma Files Investigational New Drug Application for Enhanced Microgranule Delivery Formulation of Adrulipase

First Wave BioPharma, Inc. announced that it submitted an Investigational New Drug application to the US FDA to evaluate an enhanced enteric microgranule delivery formulation of adrulipase as a treatment for exocrine pancreatic insufficiency associated with cystic fibrosis.
[First Wave Biopharma, Inc.]

Press Release

FEATURED EVENT

Pulmonary Cell News Volume 11.48 | Dec 08 2022

The Influenza-Injured Lung Microenvironment Promotes MRSA Virulence, Contributing to Severe Secondary Bacterial Pneumonia

ASK1-ER Stress Pathway-Mediated Fibrotic-EV Release Contributes to the Interaction of Alveolar Epithelial Cells and Lung Fibroblasts to Promote Mechanical Ventilation-Induced Pulmonary Fibrosis

Discovery of a Pyrano[2,3-b]pyridine Derivative YX-2102 as a Cannabinoid Receptor 2 Agonist for Alleviating Lung Fibrosis

H3K27 Tri-Demethylase JMJD3 Inhibits Macrophage Apoptosis by Promoting ADORA2A in Lipopolysaccharide-Induced Acute Lung Injury

Desloratadine, an FDA-Approved Cationic Amphiphilic Drug, Inhibits SARS-CoV-2 Infection in Cell Culture and Primary Human Nasal Epithelial Cells by Blocking Viral Entry

HIF1-α Upregulation Induces Proinflammatory Factors to Boost Host Killing Capacity after Aspergillus fumigatus Exposure

Pseudomonas aeruginosa Promotes Persistence of Stenotrophomonas maltophilia via Increased Adherence to Depolarized Respiratory Epithelium

Honokiol Inhibits Interleukin-Induced Angiogenesis in the NSCLC Microenvironment through the NF-κB Signaling Pathway

ANGPTL4 Regulates Lung Adenocarcinoma Pyroptosis and Apoptosis via NLRP3\ASC\Caspase 8 Signaling Pathway to Promote Resistance to Gefitinib

Human Lung Organoid: Models for Respiratory Biology and Diseases

First Wave Biopharma Files Investigational New Drug Application for Enhanced Microgranule Delivery Formulation of Adrulipase

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