Pulmonary Cell News Volume 11.49 | Dec 15 2022

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    2022-12-15 | PULCN 11.49


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.49 – 15 December, 2022
    TOP STORY

    The Establishment of COPD Organoids to Study Host-Pathogen Interaction Reveals Enhanced Viral Fitness of SARS-CoV-2 in Bronchi

    Scientists described the establishment of nasopharyngeal and bronchial organoids from healthy individuals and chronic obstructive pulmonary disease that recapitulated the disease at the individual level.
    [Nature Communications]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTectâ„¢ CRISPR-Cas9 System.
    PUBLICATIONSRanked by the impact factor of the journal

    Myeloperoxidase-Derived Hypochlorous Acid Targets Human Airway Epithelial Plasmalogens Liberating Protein Modifying Electrophilic 2-Chlorofatty Aldehydes

    Researchers demonstrated that small airway epithelial cells contained plasmalogens enriched with oleic acid at the sn-2 position, unlike endothelial cells which containe arachidonic acid enrichment at the sn-2 position of plasmalogen.
    [Redox Biology]

    Full ArticleGraphical Abstract

    Arsenic Trioxide Promotes ERK1/2-Mediated Phosphorylation and Degradation of BIMEL to Attenuate Apoptosis in BEAS-2B Cells

    Scientists found that arsenic trioxide decreased BCL-2-interacting mediator of cell death protein (BIMEL) levels in human bronchial epithelial cell line and increased BIMEL levels in human lung carcinoma cell line A549 and mouse Sertoli cell line TM4.
    [Chemico-Biological interactions]

    Abstract

    Synergism of TNF-α and IFN-β Triggers Human Airway Epithelial Cells Death by Apoptosis and Pyroptosis

    Investigators modeled the effect of pro-inflammatory cytokines on human airway epithelial cells by culturing human airway epithelial cells BEAS-2B under different combinations of cytokines and reported that TNF-α and IFN-β synergistically induced BEAS-2B death.
    [Molecular Immunology]

    Full Article

    Nonmuscle Myosin IIA Promotes the Internalization of Influenza A Virus and Regulates Viral Polymerase Activity through Interacting with Nucleoprotein in Human Pulmonary Cells

    MYH9 depletion caused a profound inhibition of influenza A virus infection by reducing viral attachment and internalization in human lung epithelial cells.
    [Virologica Sinica]

    Full Article

    Targeting PEA3 Transcription Factors to Mitigate Small Cell Lung Cancer Progression

    Scientists found that they could model the regression and relapse seen in clinical SCLC in vitro.
    [Oncogene]

    Full Article

    Molecular Features and Evolutionary Trajectory of ASCL1+ and NEUROD1+ SCLC Cells

    Researchers studied intratumoral heterogeneity of resected human primary SCLC tissues using single-cell RNA-Seq and undertook a series of in vitro and in vivo functional studies to reveal the distinct features of SCLC subtypes.
    [British Journal of Cancer]

    Abstract

    Gene Amplification-Driven lncRNA SNHG6 Promotes Tumorigenesis via Epigenetically Suppressing p27 Expression and Regulating Cell Cycle in Non–Small Cell Lung Cancer

    Through systematically screening GSE33532 and GSE29249 from Gene Expression Omnibus database and bioinformatics analysis, investigators found the significant upregulation of SNHG6 in NSCLC.
    [Cell Death Discovery]

    Full Article

    Non–Small Cell Lung Cancer-Derived Exosomes Promote Proliferation, Phagocytosis, and Secretion of Microglia via Exosomal microRNA in the Metastatic Microenvironment

    Researchers observed that microglia aggregated around the brain metastatic sites in mouse models and NSCLC patients’ specimens.
    [Translational Oncology]

    Full Article
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    REVIEWS

    Effect of Chromatin Modifiers on the Plasticity and Immunogenicity of Small-Cell Lung Cancer

    The authors highlight studies in which imbalance of chromatin modifiers with opposing functions led to loss of immune recognition markers, effectively masking tumor cells from the immune system.
    [Experimental and Molecular Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Peroxitech Announces Closing of $25M Series A Financing to Develop Novel Treatment for Acute Lung Injury

    Peroxitech Inc. announced the successful completion of a Series A financing round of $25 million led by the Perceptive Xontogeny Venture Fund.
    [Peroxitech, Inc.(Business Wire)]

    Press Release
    FEATURED EVENT

    Drug Delivery to the Brain: Challenges and Progress

    January 23 – 25, 2023
    Breckenridge, Colorado, United States

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    JOB OPPORTUNITIES

    Postdoctoral Scholar – Glioblastoma Tumor Growth

    University of California Irvine – Irvine, California, United States

    Postdoctoral Scientist – Neuroimmune Organoids

    VIB-UAntwerp – Antwerp, Belgium

    Postdoctoral Position – Nervous Organoids & Biomimetic Nanomaterials 3D Cultures

    Center for Nanomedicine and Tissue Engineering – Milan, Italy

    PhD Position – Glioblastoma Nanobodies

    University of Melbourne – Melbourne, Victoria, Australia

    Senior Program Associate – Science in the City

    STEMCELL Technologies, Inc. – Boston, Massachusetts, United States

    > See All Jobs

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