Pulmonary Cell News Volume 12.00 | Jan 05 2023

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    2023-01-05 | PULCN 12.00


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.00 – 5 January, 2023
    TOP STORY

    MFG-E8 Stabilized by Deubiquitinase USP14 Suppresses Cigarette Smoke-Induced Ferroptosis in Bronchial Epithelial Cells

    Researchers showed that cigarette smoke diminished milk fat globule epidermal growth factor 8 (MFG-E8) protein levels but had no significant effect on its mRNA levels in the lung tissues of humans and mice and in two human bronchial epithelial cell lines.
    [Cell Death & Disease]

    Full Article
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    Attenuating Endothelial Leakiness with Self-Assembled DNA Nanostructures for Pulmonary Arterial Hypertension

    Investigators proposed a strategy that used endothelial targeting DNA nanostructures to deliver Atg101 siRNA as a safe, biocompatible “band-aid” to restore pulmonary arterial endothelial barrier integrity within the intricate milieu of pulmonary cells and the pulmonary vasculature.
    [Nanoscale Horizons]

    AbstractGraphical Abstract

    Coal Dust Nanoparticles Induced Pulmonary Fibrosis by Promoting Inflammation and Epithelial-Mesenchymal Transition via the NF-κB/NLRP3 Pathway Driven by IGF1/ROS-Mediated AKT/GSK3β Signals

    The authors investigated the roles and interrelationships of the IGF1/IGF1R signaling, ROS generation, AKT/GSK3β signaling, and NF-κB/NLRP3 signaling in coal dust-nanoparticles-induced pulmonary fibrosis (CD-NPs-induced PF), thereby elucidating the potential mechanism of CD-NPs-induced PF.
    [Cell Death Discovery]

    Full ArticleGraphical Abstract

    GSDMD Deficiency Ameliorates Hyperoxia-Induced BPD and ROP In Neonatal Mice

    Scientists showed that global Gasdermin D knockout (GSDMD-KO) protected against hyperoxia-induced bronchopulmonary dysplasia (BPD) by reducing macrophage infiltration, improving alveolarization and vascular development, and decreasing cell death.
    [Scientific Reports]

    Full Article

    Volatile Metabolites Differentiate Air–Liquid Interface Cultures after Infection with Staphylococcus aureus

    The authors investigated the role and function of volatile organic compounds (VOCs) in bacterial-host-stress response through representative in vitro models. They sampled VOCs from the headspace of A549 cells at an air–liquid interface.
    [Analyst]

    Full ArticleGraphical Abstract

    4EBP1 Senses Extracellular Glucose Deprivation and Initiates Cell Death Signaling in Lung Cancer

    Researchers discovered that 4E binding protein 1 (4EBP1) could regulate cancer cell death under glucose deprivation conditions, elucidating a key role for 4EBP1 to regulate cell viability in response to glucose starvation conditions, which differed from its translational repression function.
    [Cell Death & Disease]

    Full Article

    Co-Targeting BCL-XL and MCL-1 with DT2216 and AZD8055 Synergistically Inhibit Small-Cell Lung Cancer Growth without Causing On-Target Toxicities in Mice

    Investigators developed an effective and safe strategy targeting anti-apoptotic proteins with DT2216, a platelet-sparing BCL-XL degrader, and AZD8055, an mTOR inhibitor, to avoid associated on-target toxicities while synergistically optimizing tumor response.
    [Cell Death Discovery]

    Full Article

    Therapeutic Efficacy of Cyclin-Dependent Kinase Inhibition in Combination with Ionizing Radiation for Lung Cancer

    Scientists evaluated the therapeutic efficacy of cyclin-dependent kinase inhibition in combination with ionizing radiation for lung cancer.
    [International Journal Of Radiation Biology]

    Abstract

    MiR-138-5p Suppresses the Progression of Lung Cancer by Targeting SNIP1

    Researchers evaluated the roles of miR-138-5p in lung cancer progression and the value of miR-138-5p in lung cancer diagnosis.
    [Thoracic Cancer]

    Full Article
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    REVIEWS

    Hypoxia-Inducible Factor 1α and Its Role in Lung Injury: Adaptive or Maladaptive

    The authors summarize the effects of hypoxia-inducible factor (HIF)-1α on the vasculature, metabolism, inflammation, and apoptosis in the lungs and review the role of HIFs in direct lung injuries, including lung contusion, acid aspiration, pneumonia, and COVID-19.
    [Inflammation]

    Full Article
    INDUSTRY AND POLICY NEWS

    FoundationOne® Liquid CDx Receives FDA Approval as a Companion Diagnostic for Rozlytrek® (entrectinib)

    Foundation Medicine, Inc. announced the US FDA approved FoundationOne® Liquid CDx to be used as a companion diagnostic to identify patients with ROS1-positive NSCLC, or patients with NTRK fusion-positive solid tumors that may be appropriate for treatment with Rozlytrek.
    [Foundation Medicine, Inc.]

    Press Release
    FEATURED EVENT

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    February 5 – 8, 2023
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    JOB OPPORTUNITIES

    Postdoctoral Research – Translational Lung Cancer

    Karolinska Institute – Stockholm, Sweden

    Research Assistant – Pulmonary Medicine

    University of Texas – Houston, Texas, United States

    Research Associate – Asthma and Allergy

    University of California, San Diego – La Jolla, California, United States

    Group Leader – Computational Epigenomics

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Postdoctoral Scientist – Cancer Therapeutics

    UTHSC-Houston – Houston, Texas, United States

    > See All Jobs

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