 | | Vol. 12.01 – 12 January, 2023 |
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| Researchers presented that CGRP negatively regulated the antibacterial process of host cells. They uncovered a unique role of CGRP in inhibiting inflammasome activation during infections, which may shed new light on antibacterial therapies in the future.
[Cellular & Molecular Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To clarify whether host factors expressed by the cystic fibrosis epithelia may influence coronavirus disease 2019 progression, scientists described the expression of SARS-CoV-2 receptors in primary airway epithelial cells.
[Nature Communications] |
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| Investigators displayed the important interplay between the prosenescent and transforming effects of TGF-β/SMAD3 underlying mutant Ras–driven senescence and oncogenesis.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors presented that miR-33 levels were increased in bronchoalveolar lavage cells isolated from idiopathic pulmonary fibrosis patients compared to healthy controls.
[Jci Insight] |
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| Scientists defined the epitranscriptomic m6A profile of SARS-CoV-2-infected human lung epithelial cells compared to uninfected controls.
[Microbiology Spectrum] |
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| In vitro anticancer activity of fungal extract by MTT assay displayed a high cytotoxic effect on human lung carcinoma cancer cell line, A549, and without any significant cytotoxic effect on human breast cancer cell line (MCF-7).
[Archives Of Microbiology] |
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| Investigators unveiled an immunoregulatory role for cancer cell-intrinsic IRE1α activation and suggested that targeting this pathway may help enhance anti-tumor immunity in NSCLC.
[Nature Communications] |
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| Scientists defined the role of MSCs-derived extracellular vesicles (EVs) containing miR-598 NSCLC. Co-culture experiments were conducted to examine the secretion of miR-598 by MSCs and the uptake of EVs by NSCLC cells.
[Cell Death Discovery] |
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| Researchers studied the anti-tumor effects of SHH002-hu1 against NSCLC and revealed the underlying mechanism.
[Cancer Science] |
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| The authors provided a detailed account of the role of TGF-beta in antenatal and postnatal lung development, the effect of known risk factors for bronchopulmonary dysplasia on the TGF-beta signaling pathway, and how medications for the prevention or treatment of BPD, affected TGF-beta signaling.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology] |
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| Instil Bio, Inc. announced the resumption of its Phase I clinical trial of ITIL-306 for the treatment of NSCLC, ovarian cancer, and renal cell carcinoma.
[Instil Bio, Inc.] |
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| Zai Lab Limited and Novocure announced the LUNAR study met its primary endpoint, demonstrating a statistically significant and clinically meaningful improvement in overall survival over standard therapies alone.
[Zai Lab Limited] |
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| February 9 – 12, 2023
Cancun, Mexico |
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| | Shanghai Clinical Research and Trial Center – Shanghai, China |
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| | Stanford Medicine – Stanford, California, United States |
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| | Columbia University – New York, New York, United States |
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| | University Medical Center Freiburg – Freiburg, Germany |
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| | University of California, San Diego – La Jolla, California, United States |
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