Pulmonary Cell News Volume 12.02 | Jan 19 2023

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    2023-01-19 | PULCN 12.02


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.02 – 19 January, 2023
    TOP STORY

    Organoid Modeling of Human Fetal Lung Alveolar Development Reveals Mechanisms of Cell Fate Patterning and Neonatal Respiratory Disease

    Researchers identified an alveolar-fated epithelial progenitor in human fetal lungs, which they grew as self-organizing organoids that modeled key aspects of cell lineage commitment.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Timing and Cell Specificity of Senescence Drives Postnatal Lung Development and Injury

    The authors showed that lung senescence occurred at birth and decreased throughout the saccular stage in mice. Reducing senescent cells at this stage disrupted lung development.
    [Nature Communications]

    Full Article

    SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator Modulators

    Scientists found that the PDZ-binding motifs of SARS-CoV, MERS-CoV, and SARS-CoV-2 were virulence factors required for optimal replication and the generation of alveolar edema.
    [Biomaterials Science]

    Full Article

    Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro

    A cell model with transforming growth factor-β induction in bronchial epithelial cells was conducted to verify the effects of collagen triple helix repeat containing 1 (CTHRC1) on epithelial-mesenchymal transition.
    [Inflammation]

    AbstractGraphical Abstract

    α1 Adrenoreceptor Antagonism Mitigates Extracellular Mitochondrial DNA Accumulation in Lung Fibrosis Models and in Patients with IPF

    Researchers reported that noradrenaline derived from the lung’s adrenergic nerve supply drives αSMA-expressing fibroblast accumulation via mechanisms involving α1 adrenoreceptors and mitochondrial DNA.
    [American Journal Of Physiology-Lung Cellular And Molecular Physiology]

    Abstract

    The Telomerase Activator TA-65 Protects from Cigarette Smoke-Induced Small Airway Remodeling in Mice through Extra-Telomeric Effects

    Scientists identified a potential protective role of TA-65, a pharmacological telomerase activator, in a cigarette smoke model of small airway remodeling in mice, and further studied if extra-telomeric effects of telomerase, involving oxidative stress modulation, could explain it.
    [Scientific Reports]

    Full Article

    In Vivo Induction of Activin A-producing Alveolar Macrophages Supports the Progression of Lung Cell Carcinoma

    Using an orthotopic murine lung cancer model and human carcinoma samples, investigators found that alveolar macrophages supported cancer cell proliferation and thus contributed to unfavourable outcomes.
    [Nature Communications]

    Full Article

    The Germline Factor DDX4 Contributes to the Chemoresistance of Small Cell Lung Cancer Cells

    Scientists demonstrated that DEAD-box helicase 4 (DDX4), a germline factor and RNA helicase conserved in all multicellular organisms, contributed to increased cell motility and cisplatin-mediated drug resistance in SCLC cells.
    [Communications Biology]

    Full Article

    Phosphorylation of TGIF2 Represents a Therapeutic Target That Drives EMT and Metastasis of Lung Adenocarcinoma

    Researchers investigated the roles of phosphorylated TGF-β-induced factor homeobox 2 (TGIF2) in promoting epithelial–mesenchymal transition (EMT) and metastasis in lung adenocarcinoma.
    [Bmc Cancer]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTectâ„¢ CRISPR-Cas9 System.
    REVIEWS

    Role of Inhaled Antibiotics in the Era of Highly Effective CFTR Modulators

    The authors discuss the role of inhaled antibiotics in people with cystic fibrosis treated with cystic fibrosis transmembrane conductance regulator (CFTR) modulators.
    [Pulmonary Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Takeda’s EXKIVITY® (Mobocertinib) Receives Approval from the NMPA of China, Becoming the First and Only Therapy Available for Patients with EGFR Exon20 Insertion+ NSCLC

    Takeda announced that EXKIVITY® was approved by the National Medical Products Administration (NMPA) of China for the treatment of patients with locally advanced or metastatic NSCLC with epidermal growth factor receptor (EGFR) Exon20 insertion mutations.
    [Takeda]

    Press Release
    FEATURED EVENT

    ESMO Targeted Anticancer Therapies Congress 2023

    March 6 – 8, 2023
    Paris, France

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    JOB OPPORTUNITIES

    Directors of Clinical Research Programs – Cancer Biology

    IRCCS Candiolo Cancer Institute – Turin, Italy

    Post Doctoral Fellow – Lung Biology

    STEMCELL Technologies – Vancouver, British Columbia, Canada

    Group Leader – Cell Biology

    Pompeu Fabra University – Barcelona, Spain

    Physician-Scientist Positions – Clinical and Basic Research

    Shanghai Clinical Research and Trial Center – Shanghai, China

    Research Scientist – Cancer Molecular Imaging

    Stanford Medicine – Stanford, California, United States

    > See All Jobs

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