Pulmonary Cell News Volume 12.04 | Feb 02 2023

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    Jamie Kang
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    2023-02-02 | PULCN 12.04


    Pulmonary Cell News by STEMCELL Technologies
    Vol.12.04 – 2 February, 2023
    TOP STORY

    LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

    Investigators found that in human lung adenocarcinomas, triosephosphate isomerase (TPI1) activity was regulated via phosphorylation at Ser21 by the salt inducible kinases in an LKB1-dependent manner, modulating flux between completion of glycolysis and production of glycerol lipids.
    [Cancer Discovery]

    Abstract
    Explore tools and resources for your return to the lab
    PUBLICATIONSRanked by the impact factor of the journal

    Down-Regulation of KLF2 in Lung Fibroblasts Is Linked with COVID-19 Immunofibrosis and Restored by Combined Inhibition of NETs, JAK-1/2 and IL-6 Signaling

    Scientists investigated the effect of disease microenvironment on the fibrotic potential of human lung fibroblasts and its association with Kruppel-like factor 2 (KLF2) expression.
    [Clinical Immunology]

    Full Article

    BRD4 Is Involved in Viral Exacerbation of Chronic Obstructive Pulmonary Disease

    Researchers explored bromodomain protein 4 (BRD4) expression in the sputum and blood samples from stable COPD patients and COPD patients with viral exacerbation.
    [Respiratory Research]

    Full Article

    Airway and Parenchyma Transcriptomics in a House Dust Mite Model of Experimental Asthma

    Investigators performed transcriptomics on the airway and parenchyma using a house dust mite-induced model of experimental asthma that replicates key features of the human disease.
    [Respiratory Research]

    Full Article

    Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1-Nitropyrene via Nitroreduction in Human Lung Cells

    Researchers used a combination of pharmacological and genetic approaches to assess the relative importance of these enzymes and nuclear factor erythroid 2-related factor 2 in the aerobic nitroreduction of 1-Nitropyrene in human bronchial epithelial cells, A549 and HBEC3-KT.
    [Chemical Research In Toxicology]

    AbstractGraphical Abstract

    Construction of Human Three-Dimensional Lung Model Using Layer-by-Layer Method

    An LbL cell coating technique was utilized to construct a human 3D lung model in which a monolayer of the human lower airway epithelial adenocarcinoma cell line Calu-3 cells were placed on 3D-cellular multilayers composed of FN-G-coated human primary pulmonary fibroblast cells.
    [Tissue Engineering Part C-Methods]

    Abstract

    A Cell Fate Reprogramming Strategy Reverses Epithelial-to-Mesenchymal Transition of Lung Cancer Cells While Avoiding Hybrid States

    Researchers employed a systems biology approach and identified a core-regulatory circuit that plays the primary role in driving complete epithelial-to-mesenchymal transition reversal without hybrid properties.
    [Cancer Research]

    Abstract

    Serine/Threonine-Protein Kinase STK24 Induces Tumorigenesis by Regulating the STAT3/VEGFA Signaling Pathway

    Investigators demonstrated that serine/threonine-protein kinase 24 (STK24) was overexpressed in lung cancer tissues compared with normal lung tissues, and lung cancer patients with higher STK24 expression levels had shorter overall survival time.
    [Journal Of Biological Chemistry]

    Full Article

    Pacritinib Inhibits Glucose Consumption in Squamous Cell Lung Cancer Cells by Targeting FLT3

    Using a high-throughput screen, scientists discovered new compounds that blocked glucose consumption in three squamous cell lung cancer cell lines and identified 79 compounds that blocked glucose consumption in one or more of these cell lines.
    [Scientific Reports]

    Full Article
    Grow Functional Airway Organoids with PneumaCultâ„¢
    REVIEWS

    Targeting the Semaphorin3E-plexinD1 Complex in Allergic Asthma

    The authors detail the Semaphorin3E-plexinD1 axis in various aspects of asthma and highlight future directions in research including its potential role as a therapeutic target in airway allergic diseases.
    [Pharmacology & Therapeutics]

    Abstract
    INDUSTRY AND POLICY NEWS

    FDA Approves KEYTRUDA® (Pembrolizumab) as Adjuvant Treatment Following Surgical Resection and Platinum-Based Chemotherapy for Patients with Stage IB (T2a ≥4 Centimeters), II, or IIIA Non-small Cell Lung Cancer (NSCLC)

    Merck announced that the US FDA had approved KEYTRUDA, Merck’s anti-PD-1 therapy, as a single agent, for adjuvant treatment following surgical resection and platinum-based chemotherapy for adult patients with stage IB, II, or IIIA NSCLC.
    [Merck]

    Press Release
    FEATURED EVENT

    Heart Development and Disease: From Genes to Cures

    February 12 – 15, 2023
    Santa Fe, New Mexico, United States

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    JOB OPPORTUNITIES

    Scientist – Asthma & Skin Immunity

    AstraZeneca – Cambridge, England, United Kingdom

    Research Specialist – Experimental Lung Immunology

    Karolinska Institutet – Stockholm, Sweden

    Post Doctoral Fellow – Lung Biology

    STEMCELL Technologies – Vancouver, British Columbia, Canada

    Directors of Clinical Research Programs – Cancer Biology

    IRCCS Candiolo Cancer Institute – Turin, Italy

    Group Leader – Cell Biology

    Pompeu Fabra University – Barcelona, Spain

    > See All Jobs

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