| Vol. 12.07 – 23 February, 2023 |
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| Scientists reported that intranasal delivery of recombinant insulin-like growth factor binding proteins (IGFBP2) protects aged mice from weight loss and demonstrated antifibrotic effects after bleomycin lung injury. [Cell Reports Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that T-cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promoted growth and proliferation of lung cancer cells by the oxidative phosphorylation pathway. [Cell Death & Disease] |
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| Using single-cell RNA sequencing, investigators demonstrated that both infected and uninfected cells upregulated antiviral genes with nearly identical kinetics, while uninfected non-ciliated cells were the primary source of proinflammatory chemokines. [Mucosal Immunology] |
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| Scientists found that PM2.5-induced BMAL1 inhibition resulted in up-regulation of p53 protein in bronchial epithelial cells, then increased-p53 promoted autophagy [Cell Communication And Signaling] |
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| Investigators presented the structure and function of TMEM16A, the pathogenesis of pulmonary hypertension, and highlighted the role and mechanism of TMEM16A in pulmonary hypertension. [Cardiovascular Pathology] |
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| Researchers established cytotoxicity models of human lung epithelial cells and bronchial epithelial cells exposed to benzofluoranthene for 24h to reveal the mechanisms. [Journal Of Applied Toxicology] |
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| Scientists developed a highly controlled non-tumorigenic human bronchial epithelial cell system expressing four ALK fusions found in NSCLC. [Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers analyzed both RNA sequencing data and clinical outcomes obtained from public databases to identify (i) NLR family CARD domain containing 3 (NLRC3) as a tumor suppressor in lung adenocarcinoma (LUAD) and (ii) its predictive value for the likelihood of patient responsiveness to immunotherapy. [Scientific Reports] |
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| Scientists examined the potential functions of excision repair cross-complementing group 6 (ERCC6) in NSCLC. [Biochemistry And Cell Biology] |
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| Investigators review how the epithelium contributes to the development of Th2 sensitization to allergens and asthma with a “type 2-high” signature, in both murine models and human studies of this asthma endotype. [European Journal Of Immunology] |
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| The authors describe the therapeutic strategies integrating medical and radiation oncology in patients with metastatic NSCLC adenocarcinoma with central nervous system involvement and EGFR activating mutations or ALK rearrangement. [La Radiologica Medica] |
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| BiomX, Inc. announced positive results from Part 1 of the Phase Ib/IIa trial evaluating the Company’s novel phage cocktail, BX004, for the treatment of chronic pulmonary infections caused by Pseudomonas aeruginosa in patients with cystic fibrosis. [BiomX, Inc.] |
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| March 5 – 9, 2023 Banff, Alberta, Canada |
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| University of Virginia – Charlottesville, Virginia, United States |
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| University of Louisville – Louisville, Kentucky, United States |
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| STEMCELL Technologies – Vancouver, British Columbia, Canada |
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| IRCCS Candiolo Cancer Institute – Turin, Italy |
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| Pompeu Fabra University – Barcelona, Spain |
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