Pulmonary Cell News Volume 12.07 | Feb 23 2023

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    2023-02-23 | PULCN 12.07


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.07 – 23 February, 2023
    TOP STORY

    Loss of IGFBP2 Mediates Alveolar Type 2 Cell Senescence and Promotes Lung Fibrosis

    Scientists reported that intranasal delivery of recombinant insulin-like growth factor binding proteins (IGFBP2) protects aged mice from weight loss and demonstrated antifibrotic effects after bleomycin lung injury.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract
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    TIM-4 Orchestrates Mitochondrial Homeostasis to Promote Lung Cancer Progression via ANXA2/PI3K/AKT/OPA1 Axis

    Researchers found that T-cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promoted growth and proliferation of lung cancer cells by the oxidative phosphorylation pathway.
    [Cell Death & Disease]

    Full Article

    Rhinovirus C Causes Heterogeneous Infection and Gene Expression in Airway Epithelial Cell Subsets

    Using single-cell RNA sequencing, investigators demonstrated that both infected and uninfected cells upregulated antiviral genes with nearly identical kinetics, while uninfected non-ciliated cells were the primary source of proinflammatory chemokines.
    [Mucosal Immunology]

    Full Article

    BMAL1/p53 Mediating Bronchial Epithelial Cell Autophagy Contributes to PM2.5-Aggravated Asthma

    Scientists found that PM2.5-induced BMAL1 inhibition resulted in up-regulation of p53 protein in bronchial epithelial cells, then increased-p53 promoted autophagy
    [Cell Communication And Signaling]

    Full ArticleGraphical Abstract

    The Role of Transmembrane Protein 16A (TMEM16A) in Pulmonary Hypertension

    Investigators presented the structure and function of TMEM16A, the pathogenesis of pulmonary hypertension, and highlighted the role and mechanism of TMEM16A in pulmonary hypertension.
    [Cardiovascular Pathology]

    Abstract

    Benzo[b]fluoranthene Induced Oxidative Stress and Apoptosis in Human Airway Epithelial Cells via Mitochondrial Disruption

    Researchers established cytotoxicity models of human lung epithelial cells and bronchial epithelial cells exposed to benzofluoranthene for 24h to reveal the mechanisms.
    [Journal Of Applied Toxicology]

    Abstract

    ALK Fusion NSCLC Oncogenes Promote Survival and Inhibit NK Cell Responses via SERPINB4 Expression

    Scientists developed a highly controlled non-tumorigenic human bronchial epithelial cell system expressing four ALK fusions found in NSCLC.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    NLRC3 Is a Potential Prognostic Biomarker That Is Correlated with Immune Cell Infiltration in Lung Adenocarcinoma

    Researchers analyzed both RNA sequencing data and clinical outcomes obtained from public databases to identify (i) NLR family CARD domain containing 3 (NLRC3) as a tumor suppressor in lung adenocarcinoma (LUAD) and (ii) its predictive value for the likelihood of patient responsiveness to immunotherapy.
    [Scientific Reports]

    Full Article

    ERCC6 Plays a Promoting Role in the Progression of Non-Small Cell Lung Cancer

    Scientists examined the potential functions of excision repair cross-complementing group 6 (ERCC6) in NSCLC.
    [Biochemistry And Cell Biology]

    Abstract
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    REVIEWS

    Lung Epithelial Cells: Upstream Targets in Type 2-High Asthma

    Investigators review how the epithelium contributes to the development of Th2 sensitization to allergens and asthma with a “type 2-high” signature, in both murine models and human studies of this asthma endotype.
    [European Journal Of Immunology]

    Abstract

    The Role of Brain Radiotherapy for EGFR- and ALK-Positive Non-Small-Cell Lung Cancer with Brain Metastases: A Review

    The authors describe the therapeutic strategies integrating medical and radiation oncology in patients with metastatic NSCLC adenocarcinoma with central nervous system involvement and EGFR activating mutations or ALK rearrangement.
    [La Radiologica Medica]

    Full Article
    INDUSTRY AND POLICY NEWS

    BiomX Announces Positive Results from Part 1 of the Phase Ib/IIa Study Evaluating BX004 for Treatment of Chronic Pulmonary Infections in Patients with Cystic Fibrosis

    BiomX, Inc. announced positive results from Part 1 of the Phase Ib/IIa trial evaluating the Company’s novel phage cocktail, BX004, for the treatment of chronic pulmonary infections caused by Pseudomonas aeruginosa in patients with cystic fibrosis.
    [BiomX, Inc.]

    Press Release
    FEATURED EVENT

    Cancer Immunotherapy: Mechanisms of Response versus Resistance

    March 5 – 9, 2023
    Banff, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Research Scientist – Asthma, Allergy, and Immunology

    University of Virginia – Charlottesville, Virginia, United States

    Associate Professor – Pulmonary and Sleep Medicine

    University of Louisville – Louisville, Kentucky, United States

    Post Doctoral Fellow – Lung Biology

    STEMCELL Technologies – Vancouver, British Columbia, Canada

    Directors of Clinical Research Programs – Cancer Biology

    IRCCS Candiolo Cancer Institute – Turin, Italy

    Group Leader – Cell Biology

    Pompeu Fabra University – Barcelona, Spain

    > See All Jobs

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