Pulmonary Cell News Volume 12.10 | Mar 16 2023

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    2023-03-16 | PULCN 12.10


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.10 – 16 March, 2023
    TOP STORY

    Vascular-Parenchymal Crosstalk Promotes Lung Fibrosis Through BMPR2 Signaling

    Researchers studied the pathogenesis of vascular remodeling in fibrotic lungs and its contribution to the progression of fibrosis. They used an experimental model of lung fibrosis associated with pulmonary hypertension by transient overexpression of active TGF-β1.
    [American Journal Of Respiratory And Critical Care Medicine]

    Abstract
    PUBLICATIONSRanked by the impact factor of the journal

    Functional Restoration of a CFTR Splicing Mutation through RNA Delivery of CRISPR Adenine Base Editor

    To decrease the bystander edits, scientists used a specific adenosine base editing (ABE), NG-ABEmax, which was delivered as mRNA. The NG-ABEmax RNA approach was validated in patient-derived rectal organoids and bronchial epithelial cells showing sufficient gene correction to recover the CFTR function.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Novel Loss of Function KCNA5 Variants in Pulmonary Arterial Hypertension

    Researchers characterized the functional consequences of seven KCNA5 variants found in a cohort of pulmonary arterial hypertension patients.
    [American Journal Of Respiratory Cell And Molecular Biology]

    Abstract

    N6-Methyladenosine Mediates Nrf2 Protein Expression Involved in PM2.5-Induced Pulmonary Fibrosis

    Investigators explored the role and the underlying molecular mechanisms of m6A methylation of Nrf2 mRNA in PM2.5-induced pulmonary fibrosis.
    [Ecotoxicology And Environmental Safety]

    Full Article

    Andrographolide Exerts Anti-Respiratory Syncytial Virus Activity by Up-Regulating Heme Oxygenase-1 Independent of Interferon Responses in Human Airway Epithelial Cells

    In vitro respiratory syncytial virus (RSV) infection models using A549 and 16HBE cell lines were established, and the effects of andrographolide on RSV were analyzed via RSV N gene load and proinflammatory cytokine levels.
    [Molecular Biology Reports]

    Full Article

    Genotype-Phenotype Mapping of a Patient-Derived Lung Cancer Organoid Biobank Identifies NKX2-1-Defined Wnt Dependency in Lung Adenocarcinoma

    To build a preclinical platform that covered the broad disease spectrum of human lung cancer, the authors obtained lung cancer specimens from multiple sources, including sputum and circulating tumor cells, and generated a living biobank consisting of 43 lines of patient-derived lung cancer organoids.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Dual Targeting of BCL-2 and MCL-1 in the Presence of BAX Breaks Venetoclax Resistance in Human Small Cell Lung Cancer

    Scientists revealed the subtype specificity of BCL-2 expression and shed light on the mechanism of venetoclax resistance in SCLC.
    [British Journal Of Cancer]

    Abstract

    Tp53 Haploinsufficiency Is Involved in Hotspot Mutations and Cytoskeletal Remodeling in Gefitinib-Induced Drug-Resistant EGFRL858R-Lung Cancer Mice

    Investigators established in vivo animal models of gefitinib-induced drug-resistant lung cancer containing EGFRL858R and EGFRL858R*Tp53+/− mice to explore the molecular mechanisms of drug resistance by studying the genomic integrity and global gene expression.
    [Cell Death Discovery]

    Full Article

    Effect of BIM Expression on the Prognostic Value of PD-L1 in Advanced Non-Small Cell Lung Cancer Patients Treated with EGFR-TKIs

    Researchers studied whether these underlying mechanisms affect the prognostic role of programmed cell death ligand 1 (PD-L1). They enrolled patients with EGFR mutant advanced-stage NSCLC who received first-line EGFR-TKI between January 2017 and June 2019, and the treatment efficacy was assessed.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Genome-Engineering Technologies for Modeling and Treatment of Cystic Fibrosis

    The authors outline the potential and possibilities of using CRISPR/Cas9-based gene-editing technology in cystic fibrosis modeling.
    [Advances In Medical Sciences]

    Abstract
    INDUSTRY AND POLICY NEWS

    Maia Biotechnology Doses First Patients in Europe in Ongoing Phase II Trial (THIO-101) Evaluating THIO for Non-Small Cell Lung Cancer Treatment

    The primary objectives of the THIO-101 trial were to evaluate the safety and tolerability, as well as preliminary clinical efficacy of THIO, a first-in-class cancer telomere targeting agent, in patients with advanced NSCLC.
    [MAIA Biotechnology, Inc.]

    Press Release
    FEATURED EVENT

    OrganoidNL Symposium 2023

    March 31, 2023
    Amsterdam, The Netherlands

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    JOB OPPORTUNITIES

    Postdoctoral Associate – Pulmonary and Critical Care Medicine

    Duke University – Durham, North Carolina, United States

    Research Specialist – Lung Disease Research

    University of Wisconsin-Madison – Madison, Wisconsin, United States

    Assistant Clinical Research Coordinator – Childhood Pulmonary Vascular Disease

    University of California, San Francisco – San Francisco, California, United States

    Research Scientist – Asthma, Allergy, and Immunology

    University of Virginia – Charlottesville, Virginia, United States

    Post Doctoral Fellow – Lung Biology

    STEMCELL Technologies – Vancouver, British Columbia, Canada

    > See All Jobs

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