Pulmonary Cell News Volume 12.11 | Mar 23 2023

March 23, 2023

2023-03-23 | PULCN 12.11

Pulmonary Cell News by STEMCELL Technologies

Vol. 12.11 – 23 March, 2023

TOP STORY

Influence of Glycan Structure on the Colonization of Streptococcus pneumoniae on Human Respiratory Epithelial Cells

Glycan motifs important for bacterial adhesion and survival in human airway epithelial cells were systematically identified using a large collection of capsule-switch mutants.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]

Abstract

Stay current with COVID-19 research. Read Immunology of Infectious Disease News now.

PUBLICATIONSRanked by the impact factor of the journal

Evaluating the Effect of Hydrogen Sulfide in the Idiopathic Pulmonary Fibrosis Model with a Fluorescent Probe

Researchers synthesized a fluorescent probe for the selective imaging of hydrogen sulfide (H₂S) in living cells and mice. This probe was mainly used for in situ, in vivo, and cellular imaging, as well as a systematic assessment of intrapulmonary H₂S levels at different stages of idiopathic pulmonary fibrosis.
[Analytical Chemistry]

Abstract Graphical Abstract

Infection Studies with Airway Organoids from Carollia perspicillata Indicate That the Respiratory Epithelium Is Not a Barrier for Interspecies Transmission of Influenza Viruses

To analyze the susceptibility of bat airway cells to infection by viruses of other mammalian species, scientists developed an airway organoid culture model derived from airways of Carollia perspicillata.
[American Society For Microbiology]

Full Article

The Effect of HIF Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension

Investigators sought to interrogate the role of hypoxia-inducible factors in driving the activated phenotype of pulmonary hypertension cells from human and bovine vessels.
[American Journal Of Respiratory Cell And Molecular Biology]

Abstract

Diosmetin Alleviates Benzo[a]pyrene-Exacerbated H1N1 Influenza Virus-Induced Acute Lung Injury and Dysregulation of Inflammation through Modulation of the PPAR-γ-NF-κB/P38 MAPK Signaling Axis

In vitro studies showed that A549 cells with the combination of benzopyrene and H1N1 virus augmented NF-κB and P-P38 activation, accompanied by higher levels of pro-inflammatory mediators and apoptosis, all of which were also significantly reduced by diosmetin treatment.
[Food & Function]

Abstract

Knockdown of DTYMK Suppresses Progression and EMT of Lung Adenocarcinoma via STAT3 Signaling

Human tissues, A549 cells, and xenograft tumors were used to explore the regulation and mechanism of deoxythymidylate kinase on lung adenocarcinoma cell proliferation and migration.
[Physiological Genomics]

Abstract

LUNG CANCER

STAT3 Silencing by an Aptamer-Based Strategy Hampers the Crosstalk between NSCLC Cells and Cancer-Associated Fibroblasts

Scientists applied an aptamer-based conjugate to obtain signal transducer and activator of transcription-3 (STAT3) specific silencing and interfere with cancer-associated fibroblast pro-tumorigenic functions.
[Molecular Therapy – Nucleic Acids]

Abstract Graphical Abstract

Regorafenib Induces NOX5-Mediated Endoplasmic Reticulum Stress and Potentiates the Anti-Tumor Activity of Cisplatin in Non-Small Cell Lung Cancer Cells

Researchers found that regorafenib markedly enhanced cisplatin-induced cytotoxicity in lung cancer cells by activating reactive oxygen species-mediated endoplasmic reticulum stress, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase signaling pathways.
[Neoplasia]

Full Article

Oncogenic Zinc Finger Protein ZNF687 Accelerates Lung Adenocarcinoma Cell Proliferation and Tumor Progression by Activating the PI3K/AKT Signaling Pathway

The activation of the PI3K/AKT signaling pathway upregulated zinc finger protein 687 (ZNF687) and increased the proliferation of lung adenocarcinoma cells and tumor progression.
[Thoracic Cancer]

Full Article

Resources for Your T Cell Therapy Research

REVIEWS

An Update in Club Cell Biology and Its Potential Relevance to Chronic Obstructive Pulmonary Disease

Investigators integrate findings from scRNA-seq experiments with earlier in vitro, in vivo, and microscopy studies and highlight the many ways club cells contribute to airway homeostasis.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology]

Abstract

Advances in Respiratory Physiology in Mouse Models of Experimental Asthma

The authors discuss key distinctions in respiratory physiology between asthma and severe asthma, including the magnitude of airway hyperresponsiveness and recently discovered disease drivers that underpin this phenomenon such as structural changes and inflammation.
[Frontiers In Physiology]

Full Article

INDUSTRY AND POLICY NEWS

Ohio Train Derailment: Scientists Scan for Lingering Toxics

Officials at the US Environmental Protection Agency and local, state, and federal agencies, as well as the train’s operator, Norfolk Southern, have been monitoring water and air quality in the town — but community members haven’t been satisfied with official reports claiming that levels of the chemicals are low and safe.
[Nature]

Press Release

Tenax Announces Issuance of US Patent Covering Use of IV Levosimendan in Pulmonary Hypertension with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)

Tenax Therapeutics, Inc. announced that the company has been issued a patent by the US Patent and Trademark Office with claims covering the use of IV levosimendan in the treatment of pulmonary hypertension associated with HFpEF.
[Tenax Therapeutics, Inc.]

Press Release

FEATURED EVENT

Pulmonary Cell News Volume 12.11 | Mar 23 2023

Influence of Glycan Structure on the Colonization of Streptococcus pneumoniae on Human Respiratory Epithelial Cells

Evaluating the Effect of Hydrogen Sulfide in the Idiopathic Pulmonary Fibrosis Model with a Fluorescent Probe

Infection Studies with Airway Organoids from Carollia perspicillata Indicate That the Respiratory Epithelium Is Not a Barrier for Interspecies Transmission of Influenza Viruses

The Effect of HIF Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension

Diosmetin Alleviates Benzo[a]pyrene-Exacerbated H1N1 Influenza Virus-Induced Acute Lung Injury and Dysregulation of Inflammation through Modulation of the PPAR-γ-NF-κB/P38 MAPK Signaling Axis

Knockdown of DTYMK Suppresses Progression and EMT of Lung Adenocarcinoma via STAT3 Signaling

STAT3 Silencing by an Aptamer-Based Strategy Hampers the Crosstalk between NSCLC Cells and Cancer-Associated Fibroblasts

Regorafenib Induces NOX5-Mediated Endoplasmic Reticulum Stress and Potentiates the Anti-Tumor Activity of Cisplatin in Non-Small Cell Lung Cancer Cells

Oncogenic Zinc Finger Protein ZNF687 Accelerates Lung Adenocarcinoma Cell Proliferation and Tumor Progression by Activating the PI3K/AKT Signaling Pathway

An Update in Club Cell Biology and Its Potential Relevance to Chronic Obstructive Pulmonary Disease

Advances in Respiratory Physiology in Mouse Models of Experimental Asthma

Ohio Train Derailment: Scientists Scan for Lingering Toxics

Tenax Announces Issuance of US Patent Covering Use of IV Levosimendan in Pulmonary Hypertension with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)

AACR Annual Meeting 2023

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Associate Professor – Pulmonary and Asthma

Associate Research Scientists – Cancer Genetics

Postdoctoral Associate – Pulmonary and Critical Care Medicine

Research Specialist – Lung Disease Research

Assistant Clinical Research Coordinator – Childhood Pulmonary Vascular Disease

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