 | | Vol. 12.12 – 29 March, 2023 |
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| Researchers used models of indolent lung adenocarcinoma metastasis to identify cancer cell-intrinsic determinants of immune reactivity during exit from dormancy.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators determined the mechanism and subtype of aged T cells affecting alveolar type II epithelial cells, which promoted the pathogenesis of senescence-associated pulmonary fibrosis.
[Aging and Disease] |
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| Researchers investigated the role of sphingosine-1-phosphate receptor 2 (S1PR2) in cigarette smoke extract-induced inflammation and pyroptosis in human bronchial epithelial cells.
[Archives Of Medical Research] |
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| Scientists systematically integrated the metabolomics, lipidomics, and transcriptomics data obtained from the human bronchial epithelial cells exposed to particulate matter to reveal metabolic disorders in particulate matter-induced lung injury.
[Ecotoxicology And Environmental Safety] |
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| Air-liquid interface cultures of well-differentiated primary human tracheal and bronchial epithelial cells were employed to study the impact of epithelial cellular composition and differentiation on SARS-CoV-2 infection by transcriptional and immunofluorescent analyses.
[Journal Of Innate Immunity] |
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| Scientists determined whether the size and chemical characteristics of typical coal-mining dust contributed to cellular toxicity. Human macrophages and bronchial tracheal epithelial cells were exposed to mining dust of three sub-micrometer and micrometer size ranges at varying concentrations.
[Scientific Reports] |
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| Investigators revealed that DEAD-box helicase 1 (DDX1) was overexpressed in NSCLC cell lines and tissues and further found that depleting DDX1 increased the sensitivity of NSCLC cells to the chemotherapy drug cisplatin, increased cell apoptosis, and inhibited cell migration and invasion.
[Life Sciences] |
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| Scientists found that transgelin protein levels increased in primary cancer-associated fibroblasts isolated from human lung cancer, compared with those in paired normal fibroblasts.
[Oncogenesis] |
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| Since the T cell-deserted tumor microenvironment of epidermal growth factor receptor-mutated lung adenocarcinoma (EGFR-mt LA) may lead to the refractoriness of immune checkpoint inhibitors against EGFR-mt LA, researchers investigated the mechanism by focusing on the regulation of chemokine expression.
[Scientific Reports] |
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| The authors propose that thalidomide can mitigate inflammation in idiopathic pulmonary fibrosis, and can be repurposed either as monotherapy or in combination with nintedanib and pirfenidone.
[Inflammopharmacology] |
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| The ORCA-3 trial randomized 792 subjects across 20 clinical locations in the United States. Similar to the Phase III ORCA-2 trial, participants received 3mg cytisinicline dosed 3 times daily for either 6 or 12 weeks and were monitored through 24 weeks post-randomization.
[Achieve Life Sciences, Inc.] |
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| April 23 – 26, 2023
Snowbird, Utah, United States |
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| | Indiana University – Indiana, Pennsylvania, United States |
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| | Ume̴ University РUme̴, Sweden |
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| | Indiana University – Indiana, Pennsylvania, United States |
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| | Columbia University – New York City, New York, United States |
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| | Duke University – Durham, North Carolina, United States |
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