 | | Vol. 12.13 – 6 April, 2023 |
| |
|
|
| Researchers proposed that environmental particulate matter measuring ≤2.5 μm, known to be associated with lung cancer risk, promoted lung cancer by acting on cells that harbor pre-existing oncogenic mutations in healthy lung tissue.
[Nature] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators reported the identification of regorafenib, an inhibitor of multiple receptor tyrosine kinases, as a senescence-attenuating drug.
[Experimental & Molecular Medicine] |
|
|
|
| Scientists showed that chronic exposure of mice to secondary organic aerosols resulted in lung inflammation and tissue destruction. They also indicated increased matrix metalloproteinase proteolytic activity suggesting its contribution to lung tissue inflammation and degradation.
[Environmental Science & Technology] |
|
|
|
| Researchers investigated the protective role of the Nrf2 signaling pathway and its bioactive molecule tectoridin in PM2.5-induced lung injury by regulating ferroptosis.
[British Journal Of Pharmacology] |
|
|
|
| Investigators presented a novel, pre-clinical model where an activating mutation in Lyn, a non-receptor Src family kinase expressed in immune cells, epithelium, and endothelium, all strongly implicated in the pathogenesis of COPD.
[American Journal Of Respiratory Cell And Molecular Biology] |
|
|
|
| Transepithelial migration through air–liquid interface cultures of reconstituted human bronchial epithelia was assessed by enzyme-linked immunosorbent assays and confocal laser scanning microscopy for different designed ankyrin repeat protein designs in comparison to a monoclonal antibody.
[Scientific Reports] |
| |
|
|
| Scientists reported that the long noncoding RNA LITATS1 was an epithelial gatekeeper in normal epithelial cells and inhibited epithelial-mesenchymal transition in breast and NSCLC cells. Transcriptome analysis identified LITATS1 as a TGF-β target gene.
[EMBO Journal] |
|
|
|
| Investigators evaluated the role of these factors in NSCLC. The role of miR-122-5p and p53 was established in samples from NSCLC patients, and human NSCLC cells A549 using the miR-122-5p inhibitor, miR-122-5p mimic, and si-p53.
[Cell Death & Disease] |
|
|
|
| Scientists reported for the first time that a key long non-coding RNA-ICL was involved in the regulation of NF-κB activity in lung cancer tissues of COPD patients.
[Cancer Cell International] |
|
|
|
|
|
| The authors review the current developments in research on various signaling pathways involved in the growth of lung cancer, as well as the underlying mechanisms of the molecules implicated.
[Molecular And Cellular Biochemistry] |
| |
|
|
| Immutep Limited announced it has signed an agreement to expand the INSIGHT-003 trial evaluating the combination of eftilagimod alpha in conjunction with the standard-of-care combination of anti-PD-1 therapy and chemotherapy in 1st line NSCLC.
[Immutep Limited] |
|
|
|
| The healthcare giant’s pharmaceutical unit Janssen announced the end of work on the adult respiratory syncytial virus vaccine program and the discontinuation of a pivotal Phase III trial.
[Fierce Biotech] |
|
|
|
|
| April 11 – 12, 2023
New York, New York, United States |
|
|
|
|
|
| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
|
|
|
| | National Institutes of Health – Research Triangle Park, North Carolina, United States |
|
|
|
| | Indiana University – Indiana, Pennsylvania, United States |
|
|
|
| | Umeå University – Umeå, Sweden |
|
|
|
| | Indiana University – Indiana, Pennsylvania, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
