Pulmonary Cell News Volume 12.14 | Apr 13 2023

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    2023-04-13 | PULCN 12.14


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.14 – 13 April, 2023
    TOP STORY

    Lung-Specific McEmp1 Functions as an Adaptor for KIT to Promote SCF-Mediated Mast Cell Proliferation

    The authors reported that mast cell-expressed membrane protein1 (MCEMP1), a lung-specific surface protein, functioned as an adaptor for KIT, which promoted stem cell factor (SCF)-mediated mast cell proliferation.
    [Nature Communications]

    Full Article
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    IRAK-M Has Effects in Regulation of Lung Epithelial Inflammation

    IL-1 receptor-associated kinase (IRAK)-M expression was significantly induced in BEAS-2B and A549 cells after inflammatory stimulation.
    [Respiratory Research]

    Full Article

    SARS-CoV-2 Infection Aggravates Cigarette Smoke-Exposed Cell Damage in Primary Human Airway Epithelia

    Investigators evaluated the role of cigarette smoke on SARS-CoV-2-induced immune and inflammatory responses, and epithelial barrier integrity leading to airway epithelial damage.
    [Virology Journal]

    Full Article

    Low Temperature Reduces Occludin Expression in Bronchial Epithelial Cells: Implications in Cold-Induced Asthma

    Scientists investigated how low temperature reduced occludin expression and compromisesd epithelial barrier function in airways resulting in in asthma exacerbation.
    [Molecular Immunology]

    Abstract

    MYC Activation Impairs Cell-Intrinsic IFNγ Signaling and Confers Resistance to Anti-PD1/PD-L1 Therapy in Lung Cancer

    Researchers studied the cell-intrinsic response of lung cancer to interferon-γ (IFNγ), a cytokine that promotes immunoresponse and modulates PD-L1 levels.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    PLCG2 Can Exist in eccDNA and Contribute to the Metastasis of Non-Small Cell Lung Cancer by Regulating Mitochondrial Respiration

    Investigators showed that the chromosome distribution, length distribution, and genomic annotation of the extrachromosomal circular DNAs (eccDNAs) were comparable between the NSCLC and normal groups.
    [Cell Death & Disease]

    Full Article

    Coxsackievirus A11 Is an Immunostimulatory Oncolytic Virus That Induces Complete Tumor Regression in a Human Non-Small Cell Lung Cancer

    Coxsackievirus A11 (CVA11) infection caused extensive oncolytic activity in the examined human NSCLC cell lines, with high intercellular adhesion molecule-1 expression associated with greater CVA11-induced cytotoxicity.
    [Scientific Reports]

    Full Article

    IKZF4 Acts as a Novel Tumor Suppressor in Non-Small Cell Lung Cancer by Suppressing Notch Signaling Pathway

    Researchers showed that Ikaros zing-finger family transcription factors (IKZFs) were dysregulated in multiple tumors and IKZF4 was significantly decreased in NSCLC tissues and cell lines.
    [Cellular Signalling]

    Abstract

    JMJD5 Inhibits Lung Cancer Progression by Regulating Glucose Metabolism through the p53/TIGAR Pathway

    Scientists discovered that the knockdown of jumonji C domain-containing protein 5 (JMJD5) significantly enhanced TIGAR expression in p53 wild-type NSCLC cells, which could further suppress glycolysis and promote the pentose phosphate pathway.
    [Medical Oncology]

    Abstract
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    REVIEWS

    Toward the Next Generation EGFR Inhibitors: An Overview of Osimertinib Resistance Mediated by EGFR Mutations in Non-Small Cell Lung Cancer

    The authors focus on the acquired resistance to osimertinib caused by EGFR mutations which account for approximately 1/3 of all reported resistance mechanisms in NSCLCs.
    [Cell Communication and Signaling]

    Full Article
    INDUSTRY AND POLICY NEWS

    Transforming Low Survival Cancer Outcomes

    Queen’s researchers are among five teams receiving $29 million from the Canadian Cancer Society to jumpstart innovative research and radically change the outcomes for six of the most common and deadly cancers.
    [Queen’s University]

    Press Release
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    May 3, 2023
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    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Head and Neck Cancer

    University of Liverpool – Liverpool, England, United Kingdom

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    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Assistant Professor – Lung Transplant Surgeon

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Professor – Pulmonary Hypertension

    Indiana University – Indiana, Pennsylvania, United States

    Postdoctoral Fellowship – Matrix Biology

    National Institutes of Health – Research Triangle Park, North Carolina, United States

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