 | | Vol. 12.16 – 27 April, 2023 |
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| Investigators used single-cell cloning technologies to generate “libraries” of basal stem cells from the distal lungs of 16 patients with idiopathic pulmonary fibrosis and 10 controls.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To establish models that mimic lung complexity to different extents, researchers used five design components: cell type, membrane structure/constitution, environmental conditions, cellular arrangement, substrate, matrix structure, and composition.
[Biomaterials Research] |
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| Utilizing human precision-cut lung slices, primary human air-liquid interface differentiated airway epithelial cells, and human airway smooth muscle as pre-clinical experimental models, scientists demonstrated that RV-C15 attenuated agonist-induced bronchodilation.
[American Journal Of Respiratory Cell And Molecular Biology] |
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| Researchers demonstrated that SIRT6 was predominantly expressed in alveolar epithelial cells in human lung tissues by using a single-cell sequencing database.
[Journal Of Cellular Physiology] |
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| Investigators developed a transwell system in which airway organoid–derived differentiated human lung epithelial cells were co-cultured with primary human lung microvascular endothelial cells.
[Life Science Alliance] |
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| Elevated MYC expression following the acquisition of platinum resistance in vitro and in vivo was assessed. The capacity of enforced MYC expression to drive platinum resistance was defined in small-cell lung cancer cell lines and in a genetically engineered mouse model that expresses MYC specifically in lung tumors.
[Journal Of Experimental & Clinical Cancer Research] |
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| The authors demonstrated that dasatinib in combination with BMS-754807 inhibited lung cancer cell growth, while induced autophagy as well as cell cycle arrest at the G1 phase.
[Investigational New Drugs] |
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| Researchers determined the nonclassical mechanism of Wee1 on DNA repair regulation. Western blot was conducted to determine the mono-ubiquitination level of H2Bub.
[Thoracic Cancer] |
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| The authors investigated the effects of nimbolide (NB) on A549 human NSCLC cells. They found that NB treatment inhibits A549 cells colony formation in a dose-dependent manner.
[Applied Biochemistry And Biotechnology] |
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| Investigators review summarizes the regulatory roles of NEDD8 in the MDM2‑p53, NF‑κB, PI3K/AKT/mTOR, hypoxia‑inducible factor, Hippo and receptor tyrosine kinase signaling pathways, as well as in the development and progression of lung cancer.
[International Journal Of Oncology] |
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| Biotherapeutics has obtained approval for its investigational new drug plan to conduct Phase I.II clinical trial of the fourth-generation EGFR-mutant non-small cell lung cancer targeted agent, BBT-207, from the US FDA.
[Bridge Bio] |
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| Models showed that death rates must decline faster to meet Cancer Moonshot’s goals to cut deaths in half in 25 years.
[Nature News] |
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| May 9 – 11, 2023
Scottsdale, Arizona, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Wake Forest University – Winston Salem, North Carolina, United States |
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| | The University of Texas Health Science Center at Houston – Houston, Texas, United States |
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| | Indiana University – Indiana, Pennsylvania, United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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