Pulmonary Cell News Volume 12.18 | May 11 2023

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    Jamie Kang
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    2023-05-11 | PULCN 12.18


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.18 – 11 May, 2023
    TOP STORY

    Cloning a Profibrotic Stem Cell Variant in Idiopathic Pulmonary Fibrosis

    Scientists identified a major stem cell variant that was distinguished from normal stem cells by its ability to transform normal lung fibroblasts into pathogenic myofibroblasts in vitro and to activate and recruit myofibroblasts in clonal xenografts.
    [Science Translational Medicine]

    Abstract
    Your culture ware impacts your ALI cultures - Learn more about using Transwell inserts
    PUBLICATIONSRanked by the impact factor of the journal

    Lung Endothelial Cells Regulate Pulmonary Fibrosis through FOXF1/R-ras Signaling

    Using single cell RNA-sequencing, researchers identified endothelial transcription factors involved in lung fibrogenesis, including FOXF1, SMAD6, ETV6, and LEF1.
    [Nature Communications]

    Full Article

    Rational Engineering of Lung Alveolar Epithelium

    Scientists modulated multimodal components of the alveolar epithelial type 2 cell (AEC2) niche in decellularized lung scaffolds in order to guide AEC2 behavior for epithelial regeneration.
    [NPJ Regenerative Medicine]

    Full Article

    Optimized Spirooxindole-Pyrazole Hybrids Targeting the p53-MDM2 Interplay Induce Apoptosis and Synergize With Doxorubicin in A549 Cells

    Researchers introduced a new series of spirooxindoles via hybridization of the chemically stable core spiro-2(1H)-one and the pyrazole motif inspired by lead pyrazole-based p53 activators, the MDM2 inhibitor.
    [Scientific Reports]

    Full Article

    P21 Facilitates Macrophage Chemotaxis by Promoting CCL7 in the Lung Epithelial Cell Lines Treated with Radiation and Bleomycin

    P21 promoted CCL7 release from the severely injured lung epithelial cell lines and contributed to the macrophage chemotaxis in vitro, which provides new insights for better understanding the inflammatory responses in lung injury.
    [Journal Of Translational Medicine]

    Full Article

    Genomic Characterization Revealed PM2.5-Associated Mutational Signatures in Lung Cancer Including Activation of APOBEC3B

    Analysis of genomic and transcriptomic changes upon a PM2.5 exposure-induced human bronchial epithelial cell-based malignant transformed cell model in vitro showed that exposure led to APOBEC mutational signatures and transcriptional activation of APOBEC3B along with other potential oncogenes.
    [Environmental Science & Technology]

    AbstractGraphical Abstract

    LncRNA LINC00969 Promotes Acquired Gefitinib Resistance by Epigenetically Suppressing of NLRP3 at Transcriptional and Posttranscriptional Levels to Inhibit Pyroptosis in Lung Cancer

    By bioinformatics analysis, investigators found that LINC00969 expression was elevated in lung cancer cells with acquired gefitinib resistance. LINC00969 regulated resistance to gefitinib in vitro and in vivo.
    [Cell Death & Disease]

    Full Article

    N6-Methyladenine-Mediated Aberrant Activation of the lncRNA SOX2OT-GLI1 Loop Promotes Non-Small-Cell Lung Cancer Stemness

    Researchers investigated the molecular mechanism of non-canonical aberrant glioma-associated oncogene homolog (GLI1) upregulation. The sonic hedgehog (SHH) cascade was upregulated in stem spheres and chemo-resistant lung cancer cells and was accountable for drug resistance against multiple chemotherapy regimens.
    [Cell Death Discovery]

    Full Article

    KIF2C Accelerates the Development of Non-Small Cell Lung Cancer and Is Suppressed by miR-186-3p via the AKT-GSK3β-β-Catenin Pathway

    Scientists clarified the ability of kinesin family member 2C (KIF2C) to enhance cancer cell viability, proliferation, and invasion in NSCLC by activating the AKT-GSK3β-β-catenin pathway.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Dysregulation of Metabolic Pathways in Pulmonary Fibrosis

    The authors elucidate the role of several metabolic pathways in idiopathic pulmonary fibrosis. Moreover, they also discuss potential therapeutics which target metabolism or metabolic pathways.
    [Pharmacology & Therapeutics]

    Full Article

    Vascular Contribution to Lung Repair and Fibrosis

    Investigators summarize current findings related to lung vascular repair and regeneration and provide recent insights into the vascular abnormalities associated with the development of persistent lung fibrosis.
    [American Journal of Respiratory Cell and Molecular Biology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Vertex Announces U.S. FDA Approval for KALYDECO® (Ivacaftor) to Treat Eligible Infants With CF Ages 1 Month and Older

    Vertex Pharmaceuticals, Inc. announced the US FDA approved KALYDECO® for use in children with cystic fibrosis (CF) who have at least one mutation in their cystic fibrosis transmembrane conductance regulator gene that was responsive to the treatment based on clinical and/or in vitro assay data.
    [Vertex Pharmaceuticals, Inc.]

    Press Release
    FEATURED EVENT

    Hypoxia: From Basic Mechanisms to Emerging Therapies

    May 28 – 31, 2023
    Killarney, Ireland

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    JOB OPPORTUNITIES

    Researcher – Pediatrics Allergy & Pulmonary Medicine

    University of Washington – Medical Lake, Washington, United States

    Postdoctoral Research Associate – Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Fellow – Cancer Biology

    Wake Forest University – Winston Salem, North Carolina, United States

    Staff Scientist – Murine Phenotyping Core

    National Institutes of Health – Bethesda, Maryland, United States

    Faculty Scientist Positions – Perioperative Medicine

    The University of Texas Health Science Center at Houston – Houston, Texas, United States

    > See All Jobs

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