Pulmonary Cell News Volume 12.19 | May 18 2023

    By
    Jamie Kang
    -
    0
    10







    2023-05-18 | PULCN 12.19


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.19 – 18 May, 2023
    TOP STORY

    Biodiesel Exhaust Particle Airway Toxicity and the Role of Polycyclic Aromatic Hydrocarbons

    Scientists examined particle toxicity within the lung epithelium and the role of polycyclic aromatic hydrocarbons (PAHs). Exhaust particles from a 20% blend of fatty acid methyl ester biodiesel had little impact on primary airway epithelial toxicity compared to fossil diesel-derived particles.
    [Ecotoxicology And Environmental Safety]

    Full ArticleGraphical Abstract
    An informative, visually-compelling wallchart detailing the organization and biology of the respiratory system. Request your copy.
    PUBLICATIONSRanked by the impact factor of the journal

    4-OI Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Activating Nrf2 and Suppressing Macrophage-Mediated Epithelial-Mesenchymal Transition

    Wildtype or nuclear factor E2-related factor 2 (Nrf2) knockout mice were intratracheally injected with bleomycin to establish a pulmonary fibrosis model and then treated with 4-octyl itaconate (4-OI).
    [Inflammation Research]

    Abstract

    Copper in Airborne Fine Particulate Matter (PM2.5) From Urban Sites Causes the Upregulation of Pro-Inflammatory Cytokine IL-8 in Human Lung Epithelial A549 Cells

    Scientists investigated PM2.5 from two sites, Fukue, a remote monitoring site, and Kawasaki, an urban monitoring site, with greatly different environments and compositions.
    [Environmental Geochemistry And Health]

    Abstract

    Butyrate Inhibits iILC2-Mediated Lung Inflammation via Lung-Gut Axis in Chronic Obstructive Pulmonary Disease (COPD)

    Researchers investigated the effects and underlying mechanisms of intestinal flora metabolite butyrate on inflammatory ILC2 cells (iILC2s)-mediated lung inflammation in COPD.
    [BMC Pulmonary Medicine]

    Full Article

    Cryptotanshinone Reverses Corticosteroid Insensitivity by Inhibition of Phosphoinositide-3-Kinase-δ in Chronic Obstructive Pulmonary Disease

    The authors investigated whether cryptotanshinone could improve corticosteroid sensitivity and investigated the molecular mechanisms by which this occured.
    [International Journal Of Chronic Obstructive Pulmonary Disease]

    Full Article

    SYK-Mediated Epithelial Cell State is Associated With Response to c-Met Inhibitors in c-Met-Overexpressing Lung Cancer

    Investigators found that spleen tyrosine kinase (SYK) regulated the plasticity of cells in an epithelial state and was associated with their sensitivity to c-Met inhibitors both in vitro and in vivo in patient-derived xenograft models with c-Met overexpression regardless of MET gene status.
    [Signal Transduction And Targeted Therapy]

    Full Article

    Hypoxia-Mediated Promotion of Glucose Metabolism in Non-Small Cell Lung Cancer Correlates With Activation of the EZH2/FBXL7/PFKFB4 Axis

    Researchers revealed that the enhancer of zeste homolog 2 (EZH2)/F-box/LRR-repeat protein 7 (FBXL7)/6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) axis played a regulatory role in glucose metabolism and tumor growth of NSCLC, which was expected to be potential biomarkers for NSCLC.
    [Cell Death & Disease]

    Full Article

    Drug-Induced Lactate Confers Ferroptosis Resistance via p38-SGK1-NEDD4L-Dependent Upregulation of GPX4 in NSCLC Cells

    Scientists reported that ferroptosis represented a part of the chemotherapeutic drug etoposide-induced cell death response in SCLC cells and adaptive signaling molecule lactate protected NSCLC from etoposide-induced ferroptosis.
    [Cell Death Discovery]

    Full Article

    Nicotine Activates HIF-1α and Regulates Acid Extruders Through the Nicotinic Acetylcholine Receptor To Promote the Warburg Effect in Non-Small Cell Lung Cancer Cells

    Investigators examined the effects of nicotine on metabolic reprogramming and intracellular pH homeostasis, which were critical for cancer progression. A549 cells were exposed to nicotine in the absence and presence of the nicotinic acetylcholine receptor antagonist, mecamylamine.
    [European Journal Of Pharmacology]

    Abstract
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    REVIEWS

    Pulmonary Fibrosis in COVID19: Mechanisms, Consequences, and Targets

    Given the importance of pulmonary fibrosis irrespective of cause, understanding the similarities and differences in pathogenesis due to SARs-Cov2-induced pulmonary fibrosis may yield new therapeutic targets.
    [Qjm-An International Journal Of Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    Immutep Receives Positive Feedback from FDA on Late-Stage Clinical Development of Eftilagimod Alpha in Non-Small Cell Lung Cancer

    Immutep, Ltd. announced it has received positive feedback from the US FDA regarding the company’s late-stage clinical development plans for its first-in-class soluble LAG-3 protein and MHC Class II agonist, eftilagimod alpha, for the treatment of first line NSCLC.
    [Immutep, Ltd.]

    Press Release
    FEATURED EVENT

    The 2023 ASCO Annual Meeting

    June 2 – 6, 2023
    Chicago, Illinois, United States

    > See All Events

    JOB OPPORTUNITIES

    Staff Assistant – Pulmonary Medicine

    Rutgers University – New Brunswick, New Jersey, United States

    Researcher – Pediatrics Allergy & Pulmonary Medicine

    University of Washington – Medical Lake, Washington, United States

    Postdoctoral Research Associate – Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Fellow – Cancer Biology

    Wake Forest University – Winston Salem, North Carolina, United States

    Staff Scientist – Murine Phenotyping Core

    National Institutes of Health – Bethesda, Maryland, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Pulmonary Cell News Twitter