 | | Vol. 12.20 – 25 May, 2023 |
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| Researchers developed a synthetic, bioactive hydrogel that mimicked the native lung modulus and included a representative distribution of the most abundant extracellular matrix peptide motifs, which enabled quiescent culture of human lung fibroblasts.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the defense mechanisms against nitrosative/oxidative stress that could prevent COPD development or progression.
[American Journal Of Respiratory And Critical Care Medicine] |
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| MDCK II cells and well-differentiated human airway epithelial cell cultures were grown on porous membranes and used as models to study the interaction of B19V with the epithelial barrier.
[PLOS Pathogens] |
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| Investigators used the organoid system to identify signaling pathways that maintained the columnar shape of human lung tip progenitors. They found that EGF, FGF7, and FGF10 had distinct functions in lung tip progenitors.
[Development] |
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The accumulation of DNA double-strand breaks in primary type II alveolar epithelial cells might be an important cause of alveolar growth arrest associated with bronchopulmonary dysplasia (BPD). Rad1 could be an effective target for intervention to improve this arrest in lung development associated with BPD.
[Molecular Medicine] |
| | | Researchers reported the application of surface-enhanced Raman scattering (SERS) endoscopy, using plasmonic nanowires as SERS probes, to monitor the intracellular fate and dynamics of a common chemo-drug, doxorubicin, in A549 cancer cells.
[2D Materials] |
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| The overexpression of T-LAK cell-originated protein kinase (TOPK) significantly promoted the malignant phenotype of A549 cells, and TOPK silencing impaired the malignant phenotype with KRASG12C mutation.
[Journal Of Cellular And Molecular Medicine] |
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| Scientists reported that JWA was significantly downregulated in smoking-related lung cancer and associated with overall survival.
[Cancer & Metabolism] |
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| The antitumor activity of two novel copper(II) complexes containing a β-carboline derivative and amino acids against lung cancer cells, cervical cancer cells, and breast cancer cells was significantly superior to that of the traditional antitumor drug, cisplatin.
[Dalton Transactions] |
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| The authors discuss the potential of stimuli-responsive nanomaterials for drug delivery in lung cancer and the limitations and opportunities for improving the design of nano-based materials for the treatment of NSCLC.
[Naunyn-Schmiedebergs Archives Of Pharmacology] |
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| Immutep, Ltd. announced new encouraging clinical data in first-line NSCLC from INSIGHT-003, an investigator-initiated Phase I trial conducted by the Frankfurt Institute of Clinical Cancer Research IKF.
[Immutep, Ltd.] |
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| June 4 – 7, 2023
Heidelberg, Germany |
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| | MGH Institute of Health Professions – Boston, Massachusetts, United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | University of Washington – Medical Lake, Washington, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Wake Forest University – Winston Salem, North Carolina, United States |
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