Pulmonary Cell News Volume 12.22 | Jun 08 2023

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    Jamie Kang
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    2023-06-07 | PULCN 12.22


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 4.30 – 8 June, 2023
    TOP STORY

    Regionally Distinct Progenitor Cells in the Lower Airway Give Rise to Neuroendocrine and Multiciliated Cells in the Developing Human Lung

    Investigators applied a single-cell barcode-based lineage tracing method, called CellTagging, to track the fate of SCGB3A2/SFTPB/CFTR cells during airway organoid differentiation in vitro.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article
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    Alveolar Repair Following Lipopolysaccharide-Induced Injury Requires Cell-Extracellular Matrix Interactions

    Scientists administered E. coli lipopolysaccharide (LPS) by intratracheal injection to mice with a post-developmental deletion of β1 integrin in AT2 cells. β1-deficient AT2 cells showed persistently increased proliferation after injury, which was blocked by inhibiting NF-kB activation.
    [JCI Insight]

    Abstract

    Exoproducts of the Most Common Achromobacter Species in Cystic Fibrosis Evoke Similar Inflammatory Responses In Vitro

    Researchers compared phenotypes and proinflammatory properties of A. xylosoxidans, A. dolens, A. insuavis, and A. ruhlandii using in vitro models. Bacterial supernatants were used to stimulate cystic firbosis bronchial epithelial cells and whole blood from healthy individuals.
    [Microbiology Spectrum]

    Full Article

    Magnolol Alleviates Pulmonary Fibrosis Inchronic Obstructive Pulmonary Disease by Targeting Transient Receptor Potential Vanilloid 4-Ankyrin Repeat Domain

    Investigators studied the effect of magnolol on alleviating fibrosis in COPD based on transient receptor potential vanilloid 4 (TRPV4), and to further analyze its mechanism of action on TRPV4.
    [Phytotherapy Research]

    Abstract

    Demonstrate How Mechanical Forces Generated During Bronchoconstriction May Suppress Antiviral Responses at the Airway Epithelium Without Any Difference in Viral Replication.

    Researchers demonstrated how mechanical forces generated during bronchoconstriction may suppress antiviral responses at the airway epithelium without any difference in viral replication.
    [American Journal Of Physiology-Lung Cellular And Molecular Physiology]

    Abstract

    Overexpression of Fatty Acid Synthase Attenuates Bleomycin Induced Lung Fibrosis by Restoring Mitochondrial Dysfunction in Mice

    Investigators showed that fatty acid synthase (FASN) expression was significantly reduced in the lungs of idiopathic pulmonary fibrosis patients and bleomycin (BLM)-treated mice. Overexpression of FASN inhibited BLM-induced alveolar epithelial cell death, which was significantly potentiated by FASN knockdown.
    [Scientific Reports]

    Full Article

    PZR Promotes Tumorigenicity of Lung Cancer Cells by Regulating Cell Migration and Invasion via Modulating Oxidative Stress and Cell Adhesion

    To investigate the role of PZR, a transmembrane glycoprotein, in lung cancer, scientists employed the CRISPR technique to knockout its expression and recombinant lentiviruses to overexpress it in lung adenocarcinoma SPC-A1 cells.
    [Aging]

    Full Article

    SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence

    SET domain-containing protein 4 (SETD4)-positive cells were identified as quiescent lung cancer stem cells, since they expressed high levels of ALDH1 and CD133 and low levels of Ki67.
    [Stem Cells International]

    Full Article

    p38 MAPK Inhibitor SB203580 Enhances Anticancer Activity of PARP Inhibitor Olaparib in a Synergistic Way on Non-Small Cell Lung Carcinoma A549 Cells

    Researchers explored the potential synergistic anticancer activities of olaparib combined with p38 mitogen-activated protein kinases (MAPK) inhibitor SB203580 on NSCLC, A549 cells.
    [Biochemical And Biophysical Research Communications]

    Abstract
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    REVIEWS

    Current Treatment Strategies for EGFR-Mutated Non-Small Cell Lung Cancer: From First Line to Beyond Osimertinib Resistance

    The authors describe current pharmacotherapeutic strategies for epidermal growth factor receptor (EGFR)-mutated NSCLC based on the results of clinical trials and the latest published data.
    [Japanese Journal Of Clinical Oncology]

    Full Article
    INDUSTRY AND POLICY NEWS

    StemInov Will Bioproduct the First Cell Therapy Drug To Treat Inflammatory Diseases

    StemInov will bioproduct the first cell therapy drug from umbilical cord stem cells for the treatment of inflammatory diseases, septic shock, and acute respiratory distress syndrome.
    [StemInov ]

    Press Release
    FEATURED EVENT

    EMBO Workshop: Systems Approaches in Cancer

    June 26 – 30, 2023
    Split, Croatia

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professor – Pulmonary

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Scientist – Opportunistic Fungal Infections

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Position – Cancer Immunology

    Institut Pasteur – Paris, France

    Research Technician – Pulmonary Fibrosis

    MGH Institute of Health Professions – Boston, Massachusetts, United States

    Staff Assistant – Pulmonary Medicine

    Rutgers University – New Brunswick, New Jersey, United States

    > See All Jobs

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