Pulmonary Cell News Volume 12.23 | June 15 2023

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    Jamie Kang
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    2023-06-15 | PULCN 12.23


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.23 – 15 June, 2023
    TOP STORY

    Directed Differentiation of Mouse Pluripotent Stem Cells into Functional Lung-Specific Mesenchyme

    Researchers generated a mouse-induced pluripotent stem cell line carrying a lung-specific mesenchymal reporter/lineage tracer and identified the pathways necessary to specify lung mesenchyme.
    [Nature Communications]

    Full ArticlePress Release
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    PUBLICATIONSRanked by the impact factor of the journal

    An Inducible hACE2 Transgenic Mouse Model Recapitulates SARS-CoV-2 Infection and Pathogenesis In Vivo

    Scientists reported an inducible, transgenic human angiotensin–converting enzyme II (hACE2) mouse line and showcase three examples for specifically expressing hACE2 in three different lung epithelial cells, including AT2 cells, club cells, and ciliated cells.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    Arginase 1 and L-Arginine Coordinate Fetal Lung Development and the Initiation of Labor in Mice

    Researchers performed RNA sequencing and targeted metabolomics analyses of the lungs from fetal Src-1/-2 double-knockout mice and found that expression of arginase 1 (Arg1) was significantly decreased, accompanied by increased levels of the Arg1 substrate L-arginine.
    [EMBO Reports]

    AbstractGraphical Abstract

    Effects of Condensates from Volcanic Fumaroles and Cigarette Smoke Extracts on Airway Epithelial Cells

    Investigators assessed the effects of volcanic fumarole condensates (FC) alone or combined with cigarette smoke extracts on airway epithelial cells. Cells were exposed to FC and IL-33 and IL-8 were assessed.
    [Human Cell]

    Full Article

    Differential Regulation of BIRC2 and BIRC3 Expression by Inflammatory Cytokines and Glucocorticoids in Pulmonary Epithelial Cells

    Baculoviral inhibitor of apoptosis repeat-containing (BIRC) 2 and BIRC3 expression was characterized in pulmonary epithelial cell lines and primary human bronchial epithelial cells grown as undifferentiated cells in submersion culture or as highly differentiated cells at air-liquid interface.
    [PLOS One]

    Full Article

    PTEN Loss Confers Resistance to Anti-PD-1 Therapy in Non-Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells

    Development of a Pten-null lung squamous carcinoma mouse model revealed that tumors with PTEN loss were refractory to anti-PD-1, highly metastatic and fibrotic, and secreted TGF-β/CXCL10 to promote conversion of CD4+ lymphocytes into regulatory T cells.
    [Cancer Research]

    Abstract

    Downregulation of N6-Methyladenosine-Modified LINC00641 Promotes EMT, but Provides a Ferroptotic Vulnerability in Lung Cancer

    Scientists reported that LINC00641 was down-regulated in tumor tissues and its downregulation was associated with poor outcomes in lung adenocarcinoma. LINC00641 was localized primarily in the nucleus and was modified by m6A.
    [Cell Death & Disease]

    Full Article

    Inhalable CAR-T Cell-Derived Exosomes As Paclitaxel Carriers for Treating Lung Cancer

    Investigators engineered exosomes derived from T cells expressing the chimeric antigen receptor (CAR-Exos), which targeted mesothelin (MSLN)-expressing Lewis lung cancer through the anti-MSLN single-chain variable fragment of CAR-Exos.
    [Journal Of Translational Medicine]

    Full Article

    HDGF Promotes Gefitinib Resistance by Activating the PI3K/AKT and MEK/ERK Signaling Pathways in Non-small Cell Lung Cancer

    Researchers explored the role of hepatoma-derived growth factor (HDGF) in gefitinib resistance in NSCLC and discovered the underlying mechanisms. Stable HDGF knockout or overexpression cell lines were generated to perform experiments in vitro and in vivo.
    [Cell Death Discovery]

    Full Article
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    REVIEWS

    Extracellular Vesicles – Effectors of Transfusion-Related Acute Lung Injury

    The authors assess emerging concepts such as how extracellular vesicles mediate transfusion-related acute lung injury (TRALI), represent targets for therapeutic intervention to prevent or treat TRALI, and serve as biochemical biomarkers facilitating TRALI diagnosis and detection in at-risk patients.
    [American Journal Of Physiology-Lung Cellular And Molecular Physiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    First Wave Biopharma Reaches Enrollment Target for Phase II Span Adrulipase Clinical Trial in Cystic Fibrosis

    First Wave BioPharma, Inc. announced that it has achieved the enrollment target in its ongoing Phase II SPAN clinical trial investigating an enhanced enteric microgranule delivery formulation of adrulipase for the treatment of exocrine pancreatic insufficiency in patients with cystic fibrosis.
    [First Wave BioPharma, Inc.]

    Press Release
    FEATURED EVENT

    2nd JCA-AACR Precision Cancer Medicine International Conference

    June 28 – 30, 2023
    Kyoto, Japan

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    JOB OPPORTUNITIES

    Clinical Faculty Position – Pulmonary Medicine

    University of Florida – Gainesville, Florida, United States

    Assistant Professor – Pulmonary

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Position – Cancer Immunology

    Institut Pasteur – Paris, France

    Research Technician – Pulmonary Fibrosis

    MGH Institute of Health Professions – Boston, Massachusetts, United States

    Staff Assistant – Pulmonary Medicine

    Rutgers University – New Brunswick, New Jersey, United States

    > See All Jobs

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