Pulmonary Cell News Volume 12.24 | Jun 22 2023

    By
    Jamie Kang
    -
    0
    12







    2023-06-22 | PULCN 12.24


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.24 – 22 June, 2023
    TOP STORY

    Endothelial-Specific Loss of IKKβ Disrupts Pulmonary Endothelial Angiogenesis and Impairs Postnatal Lung Growth

    Researchers created a mouse model allowing inducible deletion of the nuclear factor-kappa B activator (IKKβ) in endothelial cells and assessed the effect on lung structure, endothelial angiogenic function, and the lung transcriptome.
    [American Journal Of Physiology-Lung Cellular And Molecular Physiology]

    Abstract
    Virtual Conference Exhibition: Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    Low-Dose Vanadium Pentoxide Perturbed Lung Metabolism Associated with Inflammation and Fibrosis Signaling in Male Animal and In Vitro Models

    Investigators examined the metabolic impact of vanadium pentoxide at relevant dietary and environmental doses in human lung fibroblasts and male C57BL/6J mice.
    [American Journal Of Physiology-Lung Cellular And Molecular Physiology]

    Abstract

    Alveolar Mitochondrial Quality Control during Acute Respiratory Distress Syndrome

    Acute respiratory distress syndrome lungs showed diffuse alveolar damage with edema, hyaline membranes, and neutrophils. A high degree of mitochondrial oxidant damage was seen in type 2 epithelial cells and alveolar macrophages.
    [Laboratory Investigation]

    Full Article

    Geranylgeranylacetone, an Inducer of Heat Shock Protein 70, Attenuates Pulmonary Fibrosis via Inhibiting NF-κB/NOX4/ROS Signaling Pathway In Vitro and In Vivo

    Researchers indicated that GGA, as an inducer of heat shock protein 70, enhanced the transformation of BEAS-2B cells from epithelial to mesenchymal cells through the NF-κB/NOX4/ROS signaling pathway and could significantly reduce apoptosis of BEAS-2B cells induced by transforming growth factor β1 in vitro.
    [Chemico-Biological Interactions]

    Abstract

    An Antioxidant Ameliorates Allergic Airway Inflammation by Inhibiting HDAC 1 via HIF-1α/VEGF Axis Suppression in Mice

    Scientists investigated possible pathways by which curcumin and sodium butyrate may minimize asthma pathogenesis via histone deacetylase 1 inhibition. Balb/c mice were exposed to Ovalbumin to establish an allergic asthma model followed by pretreatment of curcumin and sodium butyrate through intranasal route.
    [Scientific Reports]

    Full Article

    Germline Variants of the Genes Involved in NF-kB Activation Are Associated with the Risk of COPD and Lung Cancer Development

    Investigators studied whether an identified single nucleotide polymorphism has potentially an effect on proinflammatory cytokine concentration in the serum of COPD patients.
    [Acta Pharmaceutica]

    Full Article

    BACH1 Promotes Lung Adenocarcinoma Cell Metastasis through Transcriptional Activation of ITGA2

    The expression level of BACH1 in lung adenocarcinoma and its relationship with prognosis was evaluated by lung adenocarcinoma tissue microarray analysis combined with bioinformatics approaches. Gene knockdown and overexpression were used to investigate the functions and molecular mechanisms.
    [Cancer Science]

    Abstract

    USP12 Promotes Nonsmall Cell Lung Cancer Progression Through Deubiquitinating and Stabilizing RRM2

    Researchers showed that ubiquitin-specific peptidase 12 (USP12) directly interacted with and deubiquitinates RRM2 in NSCLC cells. Knockdown of USP12 caused DNA replication stress and retarded tumor growth in vivo and in vitro.
    [Molecular Carcinogenesis]

    Abstract

    CHI3L1 Induces Autophagy through the JNK Pathway in Lung Cancer Cells

    Investigators examined the association between CHI3L1 and autophagy in human lung cancer cells. In CHI3L1-overexpressing lung cancer cells, the expression of LC3, an autophagosome marker, and the accumulation of LC3 puncta increased.
    [Scientific Reports]

    Full Article
    Explore tools and resources for your return to the lab
    REVIEWS

    Clinical Insights into Small Cell Lung Cancer: Tumor Heterogeneity, Diagnosis, Therapy, and Future Directions

    The authors present an overview of multimodal clinical approaches in SCLC, with a special focus on illuminating how recent advancements in SCLC research could accelerate clinical development.
    [Clinical And Experimental Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    LumiraDx Receives UK CTDA Approval for COVID Ultra and COVID & RSV Tests

    LumiraDx, Ltd. announced that it has received validation for use by the Medicines and Healthcare Products Regulatory Agency under the Coronavirus Test Device Approvals process for the LumiraDx SARS-CoV-2 Ag Ultra and LumiraDx SARS-CoV2 Ag & RSV tests.
    [LumiraDx, Ltd.]

    Press Release
    FEATURED EVENT

    Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases

    July 17 – 20, 2023
    Burlington, Vermont, United States

    > See All Events

    JOB OPPORTUNITIES

    Director – Field Medical for GI/Skin/Lung Oncology

    Pfizer, Inc. – Southern California, United States

    Research Associate – Innate Lymphoid Cells

    King’s College London – London, England, United Kingdom

    Clinical Faculty Position – Pulmonary Medicine

    University of Florida – Gainesville, Florida, United States

    Assistant Professor – Pulmonary

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Position – Cancer Immunology

    Institut Pasteur – Paris, France

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Pulmonary Cell News Twitter