Pulmonary Cell News Volume 12.27 | Jul 13 2023

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    2023-07-13 | PULCN 12.27


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.27 – 13 July, 2023
    TOP STORY

    Cryptotanshinone Alleviates Lipopolysaccharide and Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease in Mice via the Keap1/Nrf2 Axis

    The potential effect of cryptotanshinone on COPD was investigated in a modified COPD mice model induced with cigarette smoke and lipopolysaccharide exposure.
    [Biomedicine & Pharmacotherapy]

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    Administration of A. muciniphila Ameliorates Pulmonary Arterial Hypertension by Targeting miR-208a-3p/NOVA1 Axis

    Scientists evaluated the therapeutic effects of A. muciniphila against hypoxia-induced pulmonary arterial hypertension (PH) and the underlying mechanisms. Mice were pretreated with A. muciniphila suspension every day for three weeks, and then exposed to hypoxia for another four weeks to induce PH.
    [Acta Pharmacologica Sinica]

    Abstract

    Identification of a Novel Role for TL1A/DR3 Deficiency in Acute Respiratory Distress Syndrome That Exacerbates Alveolar Epithelial Disruption

    Based on single-cell RNA and mRNA sequencing results, death receptor 3 (DR3) and its only known ligand tumor necrosis factor ligand-associated molecule 1A (TL1A) were significantly reduced in epithelium from an acute respiratory distress syndrome mice and cell models.
    [Respiratory Research]

    Full Article

    Comparison of Commercially Available Differentiation Media on Cell Morphology, Function, and Anti-Viral Responses in Conditionally Reprogrammed Human Bronchial Epithelial Cells

    Investigators compared the morphology and functional responses, including innate immune responses to rhinovirus infection in conditionally reprogrammed primary bronchial epithelial cells differentiated using two commonly used culture media.
    [Scientific Reports]

    Full Article

    IL33-Mediated NPM1 Promotes Fibroblast-to-Myofibroblast Transition via ERK/AP-1 Signaling in Silica-Induced Pulmonary Fibrosis

    Scientists demonstrated that the interleukin 33 (IL33) levels in the lung sections were significantly overexpressed after bleomycin and silica treatment. Chromatin immunoprecipitation assay, knockdown, and reverse experiments were performed in lung fibroblasts.
    [Toxicological Sciences]

    Abstract

    A Novel In Vitro Model to Study Prolonged Pseudomonas aeruginosa Infection in the Cystic Fibrosis Bronchial Epithelium

    Researchers established an in vitro model that allows for Pseudomonas aeruginosa infection of cystic fibrosis bronchial epithelial cells, cultured at the air-liquid interface, for 24 hours.
    [PLOS One]

    Full Article

    ALK Peptide Vaccination Restores the Immunogenicity of ALK-Rearranged Non-Small Cell Lung Cancer

    Scientists identified immunogenic anaplastic lymphoma kinase (ALK) peptides to show that immune checkpoint inhibitors induced rejection of ALK+ tumors in the flank but not in the lung.
    [Nature Cancer]

    Abstract

    HDAC5 Modulates SATB1 Transcriptional Activity to Promote Lung Adenocarcinoma

    Investigators highlighted the pivotal role of histone deacetylase 5 (HDAC5) in tumorigenesis. Their findings provided key insights into molecular mechanisms underlying special AT-rich sequence-binding protein-1 (SATB1)-promoted tumor growth and metastasis.
    [British Journal Of Cancer]

    Abstract

    MicroRNA-375 Restrains the Progression of Lung Squamous Cell Carcinoma by Modulating the ERK Pathway via UBE3A-Mediated DUSP1 Degradation

    To unravel the biological roles of miRNA-375, especially its specific mechanisms of action in lung squamous cell carcinoma (LUSC), LUSC tissue microarrays and miRNAscope were performed to identify the miR-375 expression.
    [Cell Death Discovery]

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    REVIEWS

    Molecular Regulation and Therapeutic Implications of Cell Death in Pulmonary Hypertension

    The authors provide a summary of the regulatory patterns of different programmed cell death modes and their potential effects on pulmonary hypertension and describe current understandings of this complex and interconnected process.
    [Cell Death Discovery]

    Full Article
    INDUSTRY AND POLICY NEWS

    Vanderbilt Researchers Envision the Potential to Grow New Lungs

    To continue their work and to determine the molecular and cellular basis for a lung disease of prematurity called bronchopulmonary dysplasia, Dr. Jennifer Sucre and her colleagues have been awarded a five-year, $3.5-million grant by the National Heart, Lung, and Blood Institute of the National Institutes of Health.
    [Vanderbilt University]

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    JOB OPPORTUNITIES

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    University of Washington – Medical Lake, Washington, United States

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    NCI Center for Cancer Research – Bethesda, Maryland, United States

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    Boston University – Boston, Massachusetts, United States

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    University of Texas at Austin – Austin, Texas, United States

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    University of Miami – Miami, Florida, United States

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