Pulmonary Cell News Volume 12.28 | Jul 20 2023

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    Jamie Kang
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    2023-07-19 | PULCN 12.28


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 4.30 – 20 July, 2023
    TOP STORY

    p53 Governs an AT1 Differentiation Programme in Lung Cancer Suppression

    Investigators showed that p53 suppressed lung adenocarcinoma (LUAD) by governing cell state, specifically by promoting alveolar type 1 differentiation. They observed graded effects of p53 on LUAD initiation and progression using murinemodels.
    [Nature]

    Abstract
    Your culture ware impacts your ALI cultures - Learn more about using Transwell inserts
    PUBLICATIONSRanked by the impact factor of the journal

    Flt1 Produced by Lung Endothelial Cells Impairs ATII Cell Transdifferentiation and Repair in Pulmonary Fibrosis

    Researchers showed that lung endothelial cells secreted angiocrine factors that regulated alveolar cell differentiation. They built on previous data on the anti-fibrotic microRNA-200c and identified the Vascular Endothelial Growth Factor receptor 1, also named Flt1, as its main functional target in endothelial cells.
    [Cell Death & Disease]

    Full Article

    Activation of α7nAChR in AT2 Promotes Alveolar Regeneration through WNT7B Signaling in Acute Lung Injury

    Scientists found that α7nAChR, α7 nicotinic acetylcholine receptor, coded by Chrna7, was expressed on AT2 cells and was upregulated in response to LPS-induced acute lung injury.
    [JCI Insight]

    AbstractGraphical Abstract

    Inhibition of Tyrosine Kinase Fgr Prevents Radiation-Induced Pulmonary Fibrosis (RIPF)

    Researchers reported that senescent cells from the lungs of mice with RIPF, released profibrotic proteins for target cells and secreted chemotactic proteins for marrow cells.
    [Cell Death Discovery]

    Full ArticleGraphical Abstract

    SARS-CoV-2 Spike Protein Induces Lung Endothelial Cell Dysfunction and Thrombo-Inflammation Depending on the C3a/C3a Receptor Signaling

    Investigators found that spike protein subunit 1 injection in mice transgenic for human angiotensin-converting enzyme 2 induced early loss of lung endothelial thromboresistance at 3 days, as revealed by thrombomodulin loss and von Willebrand factor increase.
    [Scientific Reports]

    Full ArticlePress Release

    Nootkatone Attenuates Airway Inflammation in Asthmatic Mice through Repressing ROS-Induced NLRP3 Inflammasome Activation

    Mice were sensitized and challenged with ovalbumin to establish an experimental allergic asthma model. After treatment with Nootkarone, lung tissues, peripheral blood, and bronchoalveolar lavage fluid were collected to assess inflammatory cytokines, oxidative stress, and pathological alternations.
    [Biochemistry And Cell Biology]

    Abstract

    Grading of Lung Adenocarcinomas with Simultaneous Segmentation by Artificial Intelligence (GLASS-AI)

    To achieve a objective and standardized analysis, scientists used machine learning to create GLASS-AI, a histological image analysis tool that the broader cancer research community can utilize to grade, segment, and analyze tumors in preclinical models of lung adenocarcinoma.
    [NPJ Precision Oncology]

    Full Article

    RGMb Impacts Partial Epithelial-Mesenchymal Transition and BMP2-Induced ID mRNA Expression Independent of PD-L2 in Nonsmall Cell Lung Cancer Cells

    The functions of repulsive guidance molecule b (RGMb) and PD-L2 were examined using the two NSCLC cell lines HCC827 and A549. CRISPR/Cas9 was used to decrease the expression of RGMb and PD-L2, while lentiviral vectors were used to increase their expression.
    [Cell Biology International]

    Full Article

    Claudin18.2 Expression in Pulmonary Mucinous Adenocarcinoma

    Researchers aimed to detect the expression of claudin18.2 in pulmonary invasive mucinous adenocarcinoma and its clinicopathological association with the disease.
    [Journal Of Cancer Research And Clinical Oncology]

    Abstract
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    REVIEWS

    The Lung Mesenchyme in Development, Regeneration, and Fibrosis

    The authors discuss the involvement of the lung mesenchyme in various aspects of lung biology and health, with emphasis on lung fibroblast subsets and smooth muscle cells, intercellular communication, and intrinsic mesenchymal mechanisms that drive such events throughout development, regeneration, and aging.
    [Journal Of Clinical Investigation]

    Full Article
    INDUSTRY AND POLICY NEWS

    Hillstream BioPharma Licenses Technology to Develop Proprietary HER2 and HER3 Antibody Drug Conjugates against Drug-Resistant Breast, Lung, Gastric, and Ovarian Cancers

    Hillstream BioPharma, Inc. announced the signing of an exclusive agreement with Applied Biomedical Science Institute to license technology for human antibodies targeting novel HER2 and HER3 Conformational Epitope.
    [Hillstream BioPharma, Inc.]

    Press Release
    FEATURED EVENT

    2023 Hormone-Dependent Cancers Conference GRC

    August 6 – 11, 2023
    Newry, Maine, United States

    > See All Events

    JOB OPPORTUNITIES

    Academic Physician – Sleep Medicine, COPD

    University of Alberta – Edmonton, Alberta, Canada

    Postdoctoral Research Fellow – ECM in Lung Disease

    University College Dublin – Dublin, Ireland

    Scientific Director – Clinical Research

    NCI Center for Cancer Research – Bethesda, Maryland, United States

    Postdoctoral Research Fellow – Rheumatology

    Boston University – Boston, Massachusetts, United States

    Medical Director – Pulmonary Hypertension

    University of Texas at Austin – Austin, Texas, United States

    > See All Jobs

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