Pulmonary Cell News Volume 12.29 | Jul 27 2023

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    2023-07-27 | PULCN 12.29


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.29 – 27 July, 2023
    TOP STORY

    Supersulphides Provide Airway Protection in Viral and Chronic Lung Diseases

    Investigators identified protective functions of supersulphides in viral airway infections, in aged lungs and in chronic lung diseases, including COPD and idiopathic pulmonary fibrosis.
    [Nature Communications]

    Full Article
    He needed a better model system. So he invented a new organoid. Watch James Wells' webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Modulating the m6A Modified Transcription Factor GATA6 Impacts Epithelial Cytokines in Acute Lung Injury

    Researchers reported that RNA Methyltransferase 3-mediated m6A of GATA6 mRNA inhibited acute lung injury and the secretion of pro-inflammatory cytokine in airway epithelial cells.
    [American Journal Of Respiratory Cell And Molecular Biology]

    Abstract

    Fgf9-Nolz-1-Wnt2 Axis Regulates Morphogenesis of the Lung Icon for the Forest of Biologists

    Scientists identified Nolz-1/Znf503 as a mesenchymal lineage-specific transcriptional regulator that plays a key role in lung morphogenesis. Nolz-1 null mutation resulted in a severe hypoplasia phenotype, including a decreased proliferation of mesenchymal cells and aberrant differentiation of epithelial cells.
    [Development]

    Abstract

    Human Alveolar Hydrogels Promote Morphological and Transcriptional Differentiation in iPSC-Derived Alveolar Type 2 Epithelial Cells

    As extracellular matrix (ECM) was recognized as a vital component in directing cellular function and differentiation, investigators sought to derive hydrogels from decellularized human lung alveolar-enriched ECM to provide an ex vivo model to characterize the role of physiologically relevant ECM.
    [Scientific Reports]

    Full Article

    Investigating the Link Between miR-34a-5p and TLR6 Signaling in Sepsis-Induced ARDS

    Researchers retrieved sepsis-induced acute respiratory distress syndrome (ARDS) mRNA expression profile and identified 883 differentially expressed genes. A translational study on septic mice lungs by IHC staining revealed a hike in the expression of toll-like receptor 6 (TLR6) promoted by miR-34a.
    [3 Biotech]

    Abstract

    ATR Inhibition Augments the Efficacy of Lurbinectedin in Small-Cell Lung Cancer

    Scientists found inhibitors of ataxia telangiectasia mutated and rad3 related (ATR) as the most effective agents for augmenting lurbinectedin efficacy. First-in-class ATR inhibitor berzosertib synergized with lurbinectedin in multiple SCLC cell lines, organoid, and in vivo models.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Multidirectional Characterization of Cellular Composition and Spatial Architecture in Human Multiple Primary Lung Cancers

    Investigators orchestrated the cellular and spatial architecture of multiple primary lung cancers (MPLCs) by combining single-cell RNA-sequencing and spatial transcriptomics. They identified a previously undescribed sub-population of epithelial cells termed as CLDN2+ alveolar type II which was enriched in MPLCs.
    [Cell Death & Disease]

    Full Article

    EGFR-T790M Mutation Derived Interactome Rerouted EGFR Translocation Contributing to Gefitinib Resistance in Non-Small Cell Lung Cancer

    To illuminate the molecular basis linking acquired mutation to tyrosine kinase inhibitor (TKI) resistance, affinity purification coupled mass spectrometry was adopted to dissect epidermal growth factor receptor interactome in TKI-sensitive and -resistant NSCLC cells.
    [Molecular & Cellular Proteomics]

    Full ArticleGraphical Abstract

    Histone Deacetylase Inhibitors Inhibit Lung Adenocarcinoma Metastasis via HDAC2/YY1 Mediated Downregulation of Cdh1

    Scientists employed a range of techniques, including qPCR and cell migration assays, in conjunction with online database analysis, to investigate the role of histone deacetylase inhibitors and histone deacetylase 2 (HDAC2)/YY1 in the process of lung adenocarcinoma migration.
    [Scientific Reports]

    Full Article

    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    REVIEWS

    Adenosine Receptor Signaling as a Driver of Pulmonary Fibrosis

    The authors explore the role of adenosine in fibrosis and evaluates the contribution of the different adenosine receptors to fibrogenesis.
    [Pharmacology & Therapeutics]

    Full Article

    Rational Use of Inhaled Corticosteroids for the Treatment of COPD

    Investigators review the benefits and risks of inhaled corticosteroids use in COPD, drawing on evidence from recent randomized controlled trials and observational studies conducted in primary care.
    [NPJ Primary Care Respiratory Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    The U.S. Food and Drug Administration Gives the Green Light to Molecure’s Flagship Program – Phase II Clinical Testing of OATD-01 Is Ready for Launch

    Molecure S.A. has received of its Investigational New Drug Application from the US FDA to conduct Phase II clinical testing of OATD-01, the first-ever chitotriosidase 1 inhibitor with disease-modifying potential. The first pulmonary sarcoidosis patients in this Phase II study are scheduled to begin receiving treatment..
    [Molecure S.A.]

    Press Release
    FEATURED EVENT

    2023 Lung Development, Injury, and Repair Seminar GRC

    August 12 – 13, 2023
    Waterville Valley, New Hampshire, United States

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professor – Pulmonary Medicine

    Baylor College of Medicine – Sugar Land, Texas, United States

    Academic Physician – Sleep Medicine, COPD

    University of Alberta – Edmonton, Alberta, Canada

    Project Navigator – Clinical Trial Management System

    University of Kansas Medical Center – Kansa City, Kansas, United States

    Postdoctoral Research Fellow – ECM in Lung Disease

    University College Dublin – Dublin, Ireland

    Scientific Director – Clinical Research

    NCI Center for Cancer Research – Bethesda, Maryland, United States

    > See All Jobs

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