 | | Vol. 12.30 – 3 August, 2023 |
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| Researchers developed a computational pipeline utilizing the LungMAP CellCards as a dictionary to consolidate single-cell transcriptomic datasets of 104 human lungs and 17 mouse lung samples to construct LungMAP single-cell reference for both normal human and mouse lungs.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found that p300 was upregulated in multiple epithelial cells in lung samples from patients with idiopathic pulmonary fibrosis and mouse models of lung fibrosis. Lung fibrosis was significantly diminished by the alveolar type II cell–specific deletion of the p300 gene.
[Experimental & Molecular Medicine] |
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| Researchers determined whether NLRP12 took a protective role in ozone-induced airway hyperresponsiveness and pulmonary inflammation via the suppression of canonical NF-κB.
[Ecotoxicology And Environmental Safety] |
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| Scientists revealed the role of β-Endorphin in regulating airway inflammation, cellular apoptosis, and oxidative stress via Nrf-2 in an experimental asthmatic model.
[Scientific Reports] |
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| Investigators revealed the potential of Krüppel-like factor 15 activation in alleviating pulmonary fibrosis. Transforming growth factor beta was utilized to induce lung fibroblasts to establish an in vitro model of pulmonary fibrosis.
[Tissue And Cell] |
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| | Scientists identified that THO complex (THOC) 3 was highly expressed in lung squamous cell carcinoma (LUSC) and negatively associated with prognosis. THOC3 knockdown inhibited LUSC cell growth, migration, and glycolysis.
[Cell Death & Disease] |
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| Although NR1D1 overexpression or knockdown had little effect on the proliferation of NSCLC cells in vitro, NR1D1 deficiency in the tumor microenvironment increased lung cancer development compared with the control in the orthotopic model.
[Cell Death Discovery] |
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| Scientists discovered that the E3 ligase Skp2 is overexpressed, accompanied by the downregulation of necroptosis-related regulator MLKL in human NSCLC tissues and cell lines. Knockdown of Skp2 inhibited viability, anchorage-independent growth, and in vivo tumor development of NSCLC cells.
[Communications Biology] |
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| Researchers investigated the effects of dexmedetomidine on the innate immune system, chronic inflammation, and lung cancer progression in a clinically relevant human-to-mouse xenograft model.
[Scientific Reports] |
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| The authors review the recent literature on this topic and present state-of-the-art evidence supporting the role of neuroimmune interactions in airway inflammation.
[Annals Of Allergy Asthma & Immunology] |
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| Uniphar Durbin Ireland, Ltd., and TFF Pharmaceuticals, Inc. announced the opening of an Expanded Access Program enabling patients access to TFF-VORI in the United States, Australia, United Kingdom, Canada, and select countries in Europe.
[TFF Pharmaceuticals, Inc.] |
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| August 13 – 18, 2023
Andover, New Hampshire, United States |
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| | University of Washington – Medical Lake, Washington, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | Baylor College of Medicine – Sugar Land, Texas, United States |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | University of Kansas Medical Center – Kansa City, Kansas, United States |
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