 | | Vol. 12.31 – 10 August, 2023 |
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| Researchers reported that deleting the mitochondrial electron transport chain complex I subunit Ndufs2 in lung epithelial cells during mouse gestation led to death during postnatal alveolar development.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators tested the hypothesis that loss of miR-30a would result in male and female mice experiencing similar impairments in alveolarization and angiogenesis under hyperoxic conditions.
[Biology Of Sex Differences] |
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| Using sections and hypoplastic lung explant cultures from the nitrofen rat model of congenital diaphragmatic hernia (CHD) and human fetal CDH lungs, researchers demonstrated that NF-κB and its downstream transcriptional targets are hyperactive during abnormal lung formation in CDH.
[American Journal Of Respiratory Cell And Molecular Biology] |
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| Scientists established a bronchopulmonary dysplasia mouse model to investigate the effects of tert-butylhydroquinone (TBHQ), an nuclear factor e2–related factor 2 (Nrf2) activator, on oxidative stress injury, pyroptosis, NLRP3 inflammasome activation, and alveolar development.
[Inflammation] |
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| Investigators hypothesized that Ginsenoside Rg3 may be a potential therapeutic agent for pulmonary fibrosis-targeting endothelial-to-mesenchymal transition.
[Animal Cells And Systems] |
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| | Scientists found that the lncRNA ADPGK-AS1 was substantially upregulated in artificially induced M2-like human macrophages, macrophages exposed to lung cancer cells in vitro, and tumor-associated macrophages from human lung cancer tissue.
[EMBO Journal] |
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| An increased expression of calbindin reduced CXCL8 chemokine production and downstream neutrophil recruitment in lung squamous cell carcinoma tumor cells.
[Cancer Research] |
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| Researchers reported that SCLC cells treated with an FDA-approved HDAC inhibitor SAHA underwent senescence and displayed remarkable senescence-associated secretion phenotype. In particular, SAHA promoted the formation of cytoplasmic chromatin fragments in SCLC cells.
[Cell Death Discovery] |
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| Investigators found that docetaxel induced G2/M cell cycle arrest and cell death in A549 and NCI-H1299 cells. However, many cells remained alive and became polyploid giant cancer cells by decreasing the expression of key regulatory proteins related to the cell cycle and proliferation.
[Scientific Reports] |
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| The authors identify targets of redox imbalance and inflammation that could be explored to create effective treatments for asthma.
[Molecular Biology Reports] |
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| | The planned Phase I/Ib, safety, feasibility, and light dose titration study followed by further study of therapeutic ablation effects, was designed as a multicenter, open-label study of Padeliporfin Vascular Targeted Photodynamic for lung tumor ablation in patients with Peripheral Lung Cancer.
[ImPact Biotech (Globe Newswire)] |
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| September 4 – 7, 2023
Surrey, England, United Kingdom |
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| | University of Maryland – Baltimore, Maryland, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Washington – Medical Lake, Washington, United States |
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| | IRB Barcelona – Barcelona, Spain |
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