 | | Vol. 12.32 – 17 August, 2023 |
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| Scientists hypothesized that PAR2, a G-protein coupled receptor previously implicated in the pathogenesis of various diseases including pulmonary fibrosis and asthma, may play an important role in the exacerbation of house dust mite allergen-induced lung disease by multi-walled carbon nanotubes.
[Particle And Fibre Toxicology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Primary human air-liquid interface cultures representing the broncho-alveolar epithelia were used to study the kinetics and dynamics of SARS-CoV-2 variants infection.
[iScience] |
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| Investigators evaluated the effect of flavokawain A (FKA) on pulmonary fibrosis using an animal model of bleomycin-induced pulmonary fibrosis, and showed that FKA alleviated the development of pulmonary fibrosis in a dose-dependent manner and improved lung function as well as collagen deposition.
[European Journal Of Pharmacology] |
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| Using the HSAEC1-KT human small airway epithelial (HSAE) cell line, scientists developed an in vitro model to study the interaction of two strains of A. fumigatus with bronchial and type II alveolar cell lines.
[Msphere] |
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| To gain deeper insights into the molecular mechanism underlying fibroblast growth factor (FGF) 2-mediated regulation of pulmonary fibroblasts (PFs), researchers performed mRNA sequencing analysis to systematically and globally uncover the regulated genes and biological functions of FGF2 in PFs.
[FEBS Open Bio] |
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| Scientists investigated the mechanism of forsythiaside A in treating acute lung injury (ALI) through PPAR-γ and its conjugate RXR-α based on gut-lung axis. They constructed in vitro and in vivo injury models using LPS and TNF-α.
[Journal Of Advanced Research] |
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| Investigators presented an in-depth single-cell atlas of in vitro multiculture systems on human primary airway epithelium derived from normal and diseased lungs of 27 individual donors.
[Experimental & Molecular Medicine] |
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| Scientists established the role of aescin, a triterpenoid saponin, in targeting protein kinases responsible for lung cancer proliferation and mobility.
[International Journal Of Biological Macromolecules] |
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| Researchers discovered that src homolog and collagen homolog binding protein 1 (SHCBP1) was overexpressed in lung adenocarcinoma (LUAD) tissues and was associated with a poor prognosis.
[FEBS Journal] |
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| The authors describe current knowledge of the role of the pulmonary vasculature in the development and progression of acute respiratory distress syndrome, pulmonary fibrosis, and COPD. They outline future research directions with the hope of facilitating the development of mechanism-based therapies.
[Journal Of Clinical Investigation] |
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| | The grant award will be used for the development of Bria-OTSâ„¢, personalized off-the-shelf immunotherapies for advanced metastatic breast cancer, prostate cancer, lung cancer, and melanoma.
[BrioCell Therapeutics, Corp.] |
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| September 13 – 15, 2023
Seogwipo, South Korea |
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| | University of Washington – Medical Lake, Washington, United States |
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| | Creative Biolabs – New York, New York, United States |
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| | University of Giessen – Giessen, Germany |
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| | University of Maryland – Baltimore, Maryland, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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