Pulmonary Cell News Volume 12.33 | Aug 24 2023

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    Jamie Kang
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    2023-08-24 | PULCN 12.32


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.33 – 24 August, 2023
    TOP STORY

    KDM6A Epigenetically Regulates Subtype Plasticity in Small Cell Lung Cancer

    Using a CRISPR-based autochthonous SCLC genetically engineered mouse model to study the consequences of KDM6A/UTX inactivation, investigators showed that KDM6A inactivation induced plasticity from ASCL1 to NEUROD1 resulting in SCLC tumors that expressed both ASCL1 and NEUROD1.
    [Nature Cell Biology]

    Abstract
    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    Harnessing Graphene Oxide Nanocarriers for siRNA Delivery in a 3D Spheroid Model of Lung Cancer

    Scientists analyzed the efficiency of 3D spheroids combined with a minimally modified graphene oxide-based nanocarrier for siRNA delivery as a new system for cell transfection.
    [Biomaterials Science]

    Full ArticleGraphical Abstract

    CYP27A1-27-Hydroxycholesterol Axis in the Respiratory System Contributes to House Dust Mite-Induced Allergic Airway Inflammation

    Researchers elucidated the contribution of the axis of 27-hydroxycholesterol derived from sterol 27-hydroxylase (CYP27A1) to the pathophysiology of asthma. House dust mite extract was intranasally administered to C57BL/6 mice and the expression of CYP27A1 in the airways was analyzed by immunostaining.
    [Allergology International]

    Full Article

    Inhibitory Effects of Schisandrin C on Collagen Behavior in Pulmonary Fibrosis

    Scientists established models of pulmonary fibrosis (PF) including a mouse model stimulated by bleomycin and a HFL1 cell model induced by transforming growth factor-β1 to evaluate the inhibition effects of Schisandrin C on PF.
    [Scientific Reports]

    Full Article

    IL-17A/p38 Signaling Pathway Induces Alveolar Epithelial Cell Pyroptosis and Hyperpermeability in Sepsis-Induced Acute Lung Injury by Activating NLRP3 Inflammasome

    Investigators explored their roles and underlying mechanisms in sepsis. The amounts of Th17 cells, IL-17A, IL-1β, IL-18, and lipopolysaccharide was significantly elevated in sepsis patients.
    [Advanced Biology]

    Abstract

    Disruption of Iron Homeostasis to Induce Ferroptosis with Albumin-Encapsulated Pt(IV) Nanodrug for the Treatment of Non-small Cell Lung Cancer

    Scientists constructed a new albumin-encapsulated platinum (Pt) (IV) nanodrug (HSA@Pt(IV)) based on the Pt(IV) drug and nanodelivery system. The characterization of nanodrug and biological experiments demonstrated its excellent drug delivery and antitumor effects.
    [Small]

    Full Article

    Cezanne Promoted Autophagy through PIK3C3 Stabilization and PIK3C2A Transcription in Lung Adenocarcinoma

    Investigators identified Cezanne, a member of the ovarian tumor protease-deubiquitinating family, as an autophagy regulator. Cezanne was highly expressed in Osimertinib-resistant cells, and Cezanne overexpression promoted Osimertinib resistance, while chloroquine, an autophagy inhibitor, reverted this process.
    [Cell Death Discovery]

    Full ArticleGraphical Abstract

    METTL3 Regulatory TROAP Can Regulate the Progression of Non-Small Cell Lung Cancer through PI3K/AKT and EMT Signaling Pathway

    Scientists assessed the biological and clinical significance of TROAP in NSCLC. RT-qPCR, western bolt, and immunohistochemistry assay were used to test TROAP RNA and protein expression not in lung adenocarcinoma (LUAD) tissues and paraneoplastic tissues but in LUAD cell lines and control cell lines.
    [Medical Oncology]

    Abstract

    Transcription Factor FOXA1 Facilitates Glycolysis and Proliferation of Lung Adenocarcinoma via Activation of TEX19

    Researchers investigated how testis expressed 19 (TEX19) works exactly in lung adenocarcinoma (LUAD). Real-time quantitative PCR assay showed that TEX19 was significantly overexpressed in LUAD cell lines compared with normal bronchial epithelial cells BEAS-2B.
    [Molecular Biotechnology]

    Abstract
    Request your free copy of the 'Growing Organoids from Stem Cells' Wallchart
    REVIEWS

    Targeting Cellular Senescence: A Promising Approach in Respiratory Diseases

    The authors present the findings from research on respiratory diseases that have utilized systems targeting senescent cells and to identify potential therapeutic strategies for the clinical management of chronic pulmonary conditions.
    [Geriatrics & Gerontology International]

    Abstract
    INDUSTRY AND POLICY NEWS

    Roche Provides Update on Phase III Skyscraper-01 Study in PD-L1-High Metastatic Non-Small Cell Lung Cancer

    Roche announced that it was made aware of an inadvertent disclosure of the second interim analysis of the Phase III SKYSCRAPER-01 study, evaluating the investigational anti-TIGIT immunotherapy tiragolumab plus Tecentriq® versus Tecentriq alone as an initial treatment for people with PD-L1-high locally advanced or metastatic NSCLC.
    [Roche]

    Press Release
    FEATURED EVENT

    Nature Forum on Translational Aspects of Infectious Diseases

    September 14, 2023
    Seogwipo, South Korea

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Functional Genomics, Molecular Genetics, Lung Cancer Susceptibility

    National Institutes of Health – Bethesda, Maryland, United States

    Postdoctoral Research Scientist – Cancer Biology

    Columbia University Irving Medical Center – New York City, New York, United States

    Researcher – Pediatrics Allergy & Pulmonary Medicine

    University of Washington – Medical Lake, Washington, United States

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Professorship – Lung Organoids and Tissue Engineering

    University of Giessen – Giessen, Germany
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