 | | Vol.12.34 – 31 August, 2023 |
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| Scientists investigated the potential effect of allyl Isothiocyanate on tracheal constriction in a house dust mite-induced asthma animal model and explored the underlying mechanisms.
[Biomedicine & Pharmacotherapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated whether platelets, specifically platelet-derived transforming growth factor-β1 (TGFβ1), mediated idiopathic pulmonary fibrosis (IPF) disease progression. IPF and non-IPF patients were recruited to determine platelet reactivity and separate cohorts of IPF patients were followed for mortality.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology] |
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| Investigators found that mice that received aerosolized caffeine had statistically significant decreases in maximum airway resistance, as well as significant delays in the time required to reach maximum resistance compared with controls.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology] |
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| Scientists tested the hypothesis that extracellular vesicles (EVs) isolated from the bronchoalveolar-lavage fluid of pediatric cystic fibrosis or pediatric asthma patients increased epithelial sodium channel activity in normal human small airway epithelial cells, and whether the mechanism involved specific EV lipids.
[Biochimica Et Biophysica Acta-Biomembranes] |
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| Researchers investigated the therapeutic potential of a novel recombinant human Cu-Zn-superoxide dismutase (SOD) fusion protein in protecting against reactive oxygen species injury and for aerosolized SOD delivery to treat Escherichia coli induced acute respiratory distress syndrome.
[Journal Of Aerosol Medicine And Pulmonary Drug Delivery] |
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| | To understand the mechanism of FGFR1 dependency, investigators performed deep genomic characterization of 52 squamous cell lung carcinomas with 8p11-p12-amplification, including 10 tumors obtained from patients who had been treated with FGFR inhibitors.
[Journal Of Clinical Investigation] |
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| Scientists conducted a thorough investigation of the genomic and transcriptomic data derived from hundreds of human cancer cell lines and primary tissue samples, with a particular focus on NSCLC.
[Cell Death & Disease] |
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| Results obtained from analyses of the Gene Expression Omnibus database of NSCLC patients showed that cartilage acidic protein 1 (CRTAC1) played a role in the response to platinum-based chemotherapy.
[Cell Death & Disease] |
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| Researchers investigated the chemopreventive role of 6-shogaol on benzopyrene-exposed lung carcinogenesis by modulating PRDX1-associated oxidative stress, inflammation, and proliferation in Swiss albino mouse models.
[Environmental Toxicology] |
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| The authors review the current state and modalities of adoptive cell therapies (ACT) in NSCLC. They also discuss the challenges hampering the use of ACT and the approaches to overcome these barriers.
[Current Oncology Reports] |
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| Scientists summarized the research progress of EGFR TKIs to dazed structure-activity relationship, biological evaluation, and comparative docking studies of pyrimidine compounds.
[Journal Of Biomolecular Structure & Dynamics] |
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| Two teams of UBC researchers have received $4.8 million to advance cancer research from the 2023 Terry Fox New Frontiers Program Project Grant competition. The projects aim to improve outcomes for patients with oral cancers and enhance lung cancer detection in individuals at high risk due to air pollution.
[UBC Faculty of Medicine] |
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| September 20 – 23, 2023
Milan, Italy |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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